CF157_DANRE
ID CF157_DANRE Reviewed; 471 AA.
AC A2BDR7; Q0V978; Q1RM17;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Cilia- and flagella-associated protein 157;
GN Name=cfap157; ORFNames=si:ch211-233f10.4;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Specifically required during spermatogenesis for flagellum
CC morphogenesis and sperm motility. {ECO:0000250|UniProtKB:Q0VFX2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000250|UniProtKB:Q0VFX2}.
CC -!- SIMILARITY: Belongs to the CFAP157 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI15177.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI21716.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BX001023; CAM14089.1; -; Genomic_DNA.
DR EMBL; BC115176; AAI15177.1; ALT_INIT; mRNA.
DR EMBL; BC121715; AAI21716.1; ALT_INIT; mRNA.
DR RefSeq; NP_001103638.1; NM_001110168.1.
DR AlphaFoldDB; A2BDR7; -.
DR SMR; A2BDR7; -.
DR STRING; 7955.ENSDARP00000104860; -.
DR PaxDb; A2BDR7; -.
DR Ensembl; ENSDART00000159599; ENSDARP00000139815; ENSDARG00000099042.
DR GeneID; 794225; -.
DR KEGG; dre:794225; -.
DR CTD; 286207; -.
DR ZFIN; ZDB-GENE-060526-118; cfap157.
DR eggNOG; ENOG502QQK8; Eukaryota.
DR GeneTree; ENSGT00730000111240; -.
DR HOGENOM; CLU_025198_2_0_1; -.
DR InParanoid; A2BDR7; -.
DR OMA; TFYELQI; -.
DR OrthoDB; 1171749at2759; -.
DR PhylomeDB; A2BDR7; -.
DR TreeFam; TF329637; -.
DR PRO; PR:A2BDR7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000099042; Expressed in liver and 10 other tissues.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR InterPro; IPR038844; CFAP157.
DR PANTHER; PTHR31954; PTHR31954; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW Differentiation; Reference proteome; Spermatogenesis.
FT CHAIN 1..471
FT /note="Cilia- and flagella-associated protein 157"
FT /id="PRO_0000307227"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 27..190
FT /evidence="ECO:0000255"
FT COILED 225..369
FT /evidence="ECO:0000255"
FT CONFLICT 19
FT /note="G -> N (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
FT CONFLICT 40
FT /note="Q -> R (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
FT CONFLICT 50
FT /note="L -> P (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
FT CONFLICT 205
FT /note="T -> A (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
FT CONFLICT 221
FT /note="T -> M (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
FT CONFLICT 245
FT /note="E -> K (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
FT CONFLICT 265
FT /note="G -> D (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
FT CONFLICT 274
FT /note="I -> M (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
FT CONFLICT 362
FT /note="N -> S (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
FT CONFLICT 370
FT /note="V -> A (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
FT CONFLICT 385
FT /note="S -> C (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
FT CONFLICT 419
FT /note="L -> F (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
FT CONFLICT 432
FT /note="P -> S (in Ref. 2; AAI21716)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 471 AA; 54196 MW; 5DFE6BD4E78E1ED3 CRC64;
MPPKKNGKKN RDQAIKTGGM EETEQKNAEE LTESDKKFYQ AQIRDLEERL ERYQLKCDEL
EVQEKDLSSK INNVEKEKKD IVLFLKRTLA KKEDKLNDLA ETLSRHQQAQ EAERESFESQ
LSLLRRELQE NKEKYTSENM TLAGKLASLE EFSTQRETLI AERRSLEEQL RKQKEDHQAE
IYNLEKKAVL DNDRLKKEML QHVATVAAEF RRVSDEKMPE TTLRAMQENL SVTAQLQQLS
EKTKELLKEN DALRARERQL KRENGITEPL LHEITKKSVA NQKVVLQLTE KCKQMQSEVE
KCTKLKQDHQ ELLDIHSAVC TEIEDLRKKH AAVTEDLNQT KAEVERQKKE LEEESRMRAQ
INTVLEEAAV ALKEALRDVP EEEDSELKVT VRRSQMMQKL LAVLDGAAAL GKGPALTDLM
TCRPGALQKT SPHLSHYKTG DLGLVPRKTH STSTKMGNLS RSAYTSLQKK A
