ID   CF157_RAT               Reviewed;         542 AA.
AC   Q4V7B0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Cilia- and flagella-associated protein 157 {ECO:0000305};
GN   Name=Cfap157 {ECO:0000312|RGD:1560002};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-31, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Specifically required during spermatogenesis for flagellum
CC       morphogenesis and sperm motility. May be required to suppress the
CC       formation of supernumerary axonemes and ensure a correct
CC       ultrastructure. {ECO:0000250|UniProtKB:Q0VFX2}.
CC   -!- SUBUNIT: Interacts with TUBB and TUBA4A. Interacts with CEP350.
CC       {ECO:0000250|UniProtKB:Q0VFX2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q0VFX2}.
CC   -!- SIMILARITY: Belongs to the CFAP157 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH98043.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC098043; AAH98043.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001094339.1; NM_001100869.1.
DR   AlphaFoldDB; Q4V7B0; -.
DR   SMR; Q4V7B0; -.
DR   STRING; 10116.ENSRNOP00000020660; -.
DR   iPTMnet; Q4V7B0; -.
DR   PhosphoSitePlus; Q4V7B0; -.
DR   PaxDb; Q4V7B0; -.
DR   PRIDE; Q4V7B0; -.
DR   Ensembl; ENSRNOT00000020660; ENSRNOP00000020660; ENSRNOG00000039315.
DR   GeneID; 499781; -.
DR   KEGG; rno:499781; -.
DR   UCSC; RGD:1560002; rat.
DR   CTD; 286207; -.
DR   RGD; 1560002; Cfap157.
DR   eggNOG; ENOG502QQK8; Eukaryota.
DR   GeneTree; ENSGT00730000111240; -.
DR   HOGENOM; CLU_025198_2_0_1; -.
DR   InParanoid; Q4V7B0; -.
DR   OMA; NMILGGK; -.
DR   OrthoDB; 1171749at2759; -.
DR   PhylomeDB; Q4V7B0; -.
DR   TreeFam; TF329637; -.
DR   PRO; PR:Q4V7B0; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000039315; Expressed in testis and 19 other tissues.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR   InterPro; IPR038844; CFAP157.
DR   PANTHER; PTHR31954; PTHR31954; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Differentiation; Phosphoprotein; Reference proteome; Spermatogenesis.
FT   CHAIN           1..542
FT                   /note="Cilia- and flagella-associated protein 157"
FT                   /id="PRO_0000307226"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          33..192
FT                   /evidence="ECO:0000255"
FT   COILED          250..370
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         31
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   542 AA;  62791 MW;  C4E3974F72ED1826 CRC64;
     MAPKKKSNKG GKEIQSKKKI GGRKDTSGSK TPELAMVEEL KEFYHKQIQD LEDRLARYQR
     KWDELAVQEK LFRQEFEQLA NNKKEIVAFL KRTLNQRVDE ITDLNDQLQS LQVAKEMEKD
     AFEAQLAQVR HEFQETKDQL TTENIALGIK LSSLEEFRLQ KEELTEKYMA LEEQLRRQEG
     EYKDYVYNLE KKSVLDKDRL RKEIIQRVNL VATEFRKVAT NQMWETTRRA ILENNNVTLQ
     LSKVSKQGVQ LLQENEQLKG AQGKLCQQLE LLENTQEIMA KKNIGNQKVI LMLTEKCRQQ
     RKGTEEAEQL RLQLFQLEQN IETLEKANQT LRSEKDQLDE QLKEQRAEAN RLQEELTKEQ
     KIRTNLKTVL TQATSLLRDI LQMRPETEDG DFDVVFQLQR KELLQQLLVL LSSAVVSKPQ
     QDMGSHQDKQ PAGLSKDSRL IAQTSKQGAA SLLQQLSTIT TYQPGDLGLV PRRLQVHIPP
     KPQDLRPLSC VTRMGICKLQ NTTEIYPSGA LKRFKKFTLP RPFLHTGRPS RCRKPDVAPV
     PP