ID   CF161_BOVIN             Reviewed;         321 AA.
AC   F6RJC2;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   10-APR-2019, sequence version 1.
DT   03-AUG-2022, entry version 14.
DE   RecName: Full=Cilia- and flagella-associated protein 161;
GN   Name=CFAP161 {ECO:0000312|VGNC:VGNC:27239};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000312|Proteomes:UP000009136};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0007744|PDB:7RRO}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), AND FUNCTION.
RX   PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA   Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA   Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA   Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT   "De novo identification of mammalian ciliary motility proteins using cryo-
RT   EM.";
RL   Cell 184:5791-5806.e19(2021).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. {ECO:0000269|PubMed:34715025}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC       {ECO:0000269|PubMed:34715025}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_005221930.1; XM_005221873.3.
DR   PDB; 7RRO; EM; 3.40 A; E/F=1-321.
DR   PDBsum; 7RRO; -.
DR   SMR; F6RJC2; -.
DR   STRING; 9913.ENSBTAP00000015744; -.
DR   Ensembl; ENSBTAT00000015744.4; ENSBTAP00000015744.4; ENSBTAG00000011861.5.
DR   GeneID; 511761; -.
DR   CTD; 161502; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011861; -.
DR   VGNC; VGNC:27239; CFAP161.
DR   GeneTree; ENSGT00390000018488; -.
DR   OMA; KREIWKN; -.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000011861; Expressed in oviduct epithelium and 93 other tissues.
DR   ExpressionAtlas; F6RJC2; baseline and differential.
DR   GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..321
FT                   /note="Cilia- and flagella-associated protein 161"
FT                   /id="PRO_0000456164"
SQ   SEQUENCE   321 AA;  36470 MW;  8C2464C5676D094F CRC64;
     MAQNLYGPRV RIGNWNEDVY LEEEIMKDFL AKRDKGQLLI QRNRRLKENL LRPMQLSVSE
     DGYIHYGDKV MLVSPDHPET EADLFLPGDL SLCMTPDEIK AHLSNELEVP CGLSAAQTKI
     PVGRNTFTIL CAAGEVIGQV LRYGQNFRLG ITGGFDDRML YLSSDHRTLL KSSKRSWLQE
     VFLTHEDSYL NCWQAAFPHP QLRLEYEGSP VPANTKILIT HCHTNRGLVA HRHLFLRTYF
     GQEAEVAAHT YLDSHRVEKP KNHWMLVTGA PRKDLSTMLD LPKPPAEDTR ALEQEREQVS
     DPGARSTPDA RGCVPQCTLP M