ID   CF161_DANRE             Reviewed;         301 AA.
AC   Q568D2;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Cilia- and flagella-associated protein 161 {ECO:0000250|UniProtKB:Q6P656};
GN   Name=cfap161 {ECO:0000250|UniProtKB:Q6P656};
GN   ORFNames=zgc:110373 {ECO:0000305};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24094744; DOI=10.1016/j.ajhg.2013.08.015;
RA   Austin-Tse C., Halbritter J., Zariwala M.A., Gilberti R.M., Gee H.Y.,
RA   Hellman N., Pathak N., Liu Y., Panizzi J.R., Patel-King R.S.,
RA   Tritschler D., Bower R., O'Toole E., Porath J.D., Hurd T.W., Chaki M.,
RA   Diaz K.A., Kohl S., Lovric S., Hwang D.Y., Braun D.A., Schueler M.,
RA   Airik R., Otto E.A., Leigh M.W., Noone P.G., Carson J.L., Davis S.D.,
RA   Pittman J.E., Ferkol T.W., Atkinson J.J., Olivier K.N., Sagel S.D.,
RA   Dell S.D., Rosenfeld M., Milla C.E., Loges N.T., Omran H., Porter M.E.,
RA   King S.M., Knowles M.R., Drummond I.A., Hildebrandt F.;
RT   "Zebrafish ciliopathy screen plus human mutational analysis identifies
RT   C21orf59 and CCDC65 defects as causing primary ciliary dyskinesia.";
RL   Am. J. Hum. Genet. 93:672-686(2013).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. {ECO:0000305|PubMed:24094744}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:F6RJC2}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes strong
CC       ciliopathy phenotypes, including pronephric cysts, axis curvature,
CC       left-right asymmetry defects and hydrocephalus. Cilia length and number
CC       appear normal, but outer dynein arms are missing and cilia are
CC       paralyzed. {ECO:0000269|PubMed:24094744}.
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DR   EMBL; BC092905; AAH92905.1; -; mRNA.
DR   RefSeq; NP_001017774.1; NM_001017774.1.
DR   AlphaFoldDB; Q568D2; -.
DR   SMR; Q568D2; -.
DR   STRING; 7955.ENSDARP00000011815; -.
DR   PaxDb; Q568D2; -.
DR   GeneID; 550471; -.
DR   KEGG; dre:550471; -.
DR   CTD; 161502; -.
DR   ZFIN; ZDB-GENE-050417-296; cfap161.
DR   eggNOG; ENOG502QRDA; Eukaryota.
DR   InParanoid; Q568D2; -.
DR   OrthoDB; 831777at2759; -.
DR   PhylomeDB; Q568D2; -.
DR   PRO; PR:Q568D2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IDA:ZFIN.
DR   GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..301
FT                   /note="Cilia- and flagella-associated protein 161"
FT                   /id="PRO_0000360982"
SQ   SEQUENCE   301 AA;  33838 MW;  743FB5D6D7CEB026 CRC64;
     MAHVRTYNPR VRVGNWKEDV TLEEETSKEF ILQKDRGELT VQKEGALKQS ILKPVSLSVS
     QDGFLHFGDT VMLVNCGDGG HMQRSPCVLS IIADSSNVTS HSQTNTGPHL LGPLQVGGAH
     SMDPCVRNTF IIISVDGSSD GEVVRYDQSF ALKTTGGFAG ELFLASDHKS FQKCAKKSRL
     QELSLVEEFD FLCWWKVLYF DPQDRLENEG YPVQVNNKVL ISHCKTNQCL AALSNHILWS
     QFGKEYELTA HTFLDSHKAE QDNNHWLFST AHPANQSQSL LQLQQEEHKE NQEDTQVKDC
     S