CF161_HUMAN
ID CF161_HUMAN Reviewed; 301 AA.
AC Q6P656; Q8N906;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Cilia- and flagella-associated protein 161 {ECO:0000312|HGNC:HGNC:26782};
GN Name=CFAP161 {ECO:0000312|HGNC:HGNC:26782};
GN Synonyms=C15orf26 {ECO:0000312|HGNC:HGNC:26782};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Heart;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000250|UniProtKB:F6RJC2}.
CC -!- INTERACTION:
CC Q6P656; P41182: BCL6; NbExp=3; IntAct=EBI-11901329, EBI-765407;
CC Q6P656; Q9BW66: CINP; NbExp=3; IntAct=EBI-11901329, EBI-739784;
CC Q6P656; Q9BPU6: DPYSL5; NbExp=3; IntAct=EBI-11901329, EBI-724653;
CC Q6P656; Q5JVL4: EFHC1; NbExp=5; IntAct=EBI-11901329, EBI-743105;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:F6RJC2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P656-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P656-2; Sequence=VSP_019511, VSP_019512, VSP_019513;
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DR EMBL; AK095934; BAC04653.1; -; mRNA.
DR EMBL; BC062471; AAH62471.1; -; mRNA.
DR CCDS; CCDS42068.1; -. [Q6P656-1]
DR RefSeq; NP_775799.2; NM_173528.2. [Q6P656-1]
DR AlphaFoldDB; Q6P656; -.
DR SMR; Q6P656; -.
DR BioGRID; 127794; 15.
DR IntAct; Q6P656; 4.
DR STRING; 9606.ENSP00000286732; -.
DR iPTMnet; Q6P656; -.
DR PhosphoSitePlus; Q6P656; -.
DR BioMuta; CFAP161; -.
DR DMDM; 74737454; -.
DR MassIVE; Q6P656; -.
DR PaxDb; Q6P656; -.
DR PeptideAtlas; Q6P656; -.
DR PRIDE; Q6P656; -.
DR ProteomicsDB; 67015; -. [Q6P656-1]
DR ProteomicsDB; 67016; -. [Q6P656-2]
DR Antibodypedia; 27916; 41 antibodies from 15 providers.
DR DNASU; 161502; -.
DR Ensembl; ENST00000286732.5; ENSP00000286732.4; ENSG00000156206.14. [Q6P656-1]
DR GeneID; 161502; -.
DR KEGG; hsa:161502; -.
DR MANE-Select; ENST00000286732.5; ENSP00000286732.4; NM_173528.4; NP_775799.2.
DR UCSC; uc002bgb.4; human. [Q6P656-1]
DR CTD; 161502; -.
DR DisGeNET; 161502; -.
DR GeneCards; CFAP161; -.
DR HGNC; HGNC:26782; CFAP161.
DR HPA; ENSG00000156206; Tissue enhanced (choroid plexus, fallopian tube).
DR neXtProt; NX_Q6P656; -.
DR OpenTargets; ENSG00000156206; -.
DR PharmGKB; PA134908662; -.
DR VEuPathDB; HostDB:ENSG00000156206; -.
DR eggNOG; ENOG502QRDA; Eukaryota.
DR GeneTree; ENSGT00390000018488; -.
DR HOGENOM; CLU_080458_0_0_1; -.
DR InParanoid; Q6P656; -.
DR OMA; KREIWKN; -.
DR OrthoDB; 831777at2759; -.
DR PhylomeDB; Q6P656; -.
DR PathwayCommons; Q6P656; -.
DR SignaLink; Q6P656; -.
DR BioGRID-ORCS; 161502; 9 hits in 1037 CRISPR screens.
DR ChiTaRS; CFAP161; human.
DR GenomeRNAi; 161502; -.
DR Pharos; Q6P656; Tdark.
DR PRO; PR:Q6P656; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q6P656; protein.
DR Bgee; ENSG00000156206; Expressed in right uterine tube and 102 other tissues.
DR ExpressionAtlas; Q6P656; baseline and differential.
DR Genevisible; Q6P656; HS.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..301
FT /note="Cilia- and flagella-associated protein 161"
FT /id="PRO_0000244092"
FT REGION 269..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..25
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_019511"
FT VAR_SEQ 194..224
FT /note="QAAFPDPQLRLEYEGFPVPANAKILINHCHT -> NMKASPSRQMLKFSSIT
FT VTQIGDWQPTGIFS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_019512"
FT VAR_SEQ 225..301
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_019513"
FT VARIANT 284
FT /note="P -> S (in dbSNP:rs2279997)"
FT /id="VAR_050883"
SQ SEQUENCE 301 AA; 34294 MW; 840E292DB566D6ED CRC64;
MAQNVYGPGV RIGNWNEDVY LEEELMKDFL EKRDKGKLLI QRSRRLKQNL LRPMQLSVTE
DGYIHYGDKV MLVNPDDPDT EADVFLRGDL SLCMTPDEIQ SHLKDELEVP CGLSAVQAKT
PIGRNTFIIL SVHRDATGQV LRYGQDFCLG ITGGFDNKML YLSSDHRTLL KSSKRSWLQE
VYLTDEVSHV NCWQAAFPDP QLRLEYEGFP VPANAKILIN HCHTNRGLAA HRHLFLSTYF
GKEAEVVAHT YLDSHRVEKP RNHWMLVTGN PRDASSSMLD LPKPPTEDTR AMEQAMGLDT
Q
