ID   CF161_MOUSE             Reviewed;         303 AA.
AC   Q6P8Y0; Q9D9X1;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Cilia- and flagella-associated protein 161 {ECO:0000312|MGI:MGI:1922806};
GN   Name=Cfap161 {ECO:0000312|MGI:MGI:1922806};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. {ECO:0000250|UniProtKB:F6RJC2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:F6RJC2}.
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DR   EMBL; AK006375; BAB24555.1; -; mRNA.
DR   EMBL; BC061016; AAH61016.1; -; mRNA.
DR   CCDS; CCDS21413.1; -.
DR   RefSeq; NP_083611.2; NM_029335.3.
DR   RefSeq; XP_006508354.1; XM_006508291.3.
DR   AlphaFoldDB; Q6P8Y0; -.
DR   SMR; Q6P8Y0; -.
DR   STRING; 10090.ENSMUSP00000011298; -.
DR   iPTMnet; Q6P8Y0; -.
DR   PhosphoSitePlus; Q6P8Y0; -.
DR   MaxQB; Q6P8Y0; -.
DR   PaxDb; Q6P8Y0; -.
DR   PRIDE; Q6P8Y0; -.
DR   ProteomicsDB; 280083; -.
DR   Antibodypedia; 27916; 41 antibodies from 15 providers.
DR   Ensembl; ENSMUST00000011298; ENSMUSP00000011298; ENSMUSG00000011154.
DR   GeneID; 75556; -.
DR   KEGG; mmu:75556; -.
DR   UCSC; uc009idv.2; mouse.
DR   CTD; 161502; -.
DR   MGI; MGI:1922806; Cfap161.
DR   VEuPathDB; HostDB:ENSMUSG00000011154; -.
DR   eggNOG; ENOG502QRDA; Eukaryota.
DR   GeneTree; ENSGT00390000018488; -.
DR   HOGENOM; CLU_080458_0_0_1; -.
DR   InParanoid; Q6P8Y0; -.
DR   OMA; KREIWKN; -.
DR   OrthoDB; 831777at2759; -.
DR   PhylomeDB; Q6P8Y0; -.
DR   BioGRID-ORCS; 75556; 3 hits in 39 CRISPR screens.
DR   PRO; PR:Q6P8Y0; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q6P8Y0; protein.
DR   Bgee; ENSMUSG00000011154; Expressed in spermatid and 57 other tissues.
DR   ExpressionAtlas; Q6P8Y0; baseline and differential.
DR   Genevisible; Q6P8Y0; MM.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   SUPFAM; SSF82109; SSF82109; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..303
FT                   /note="Cilia- and flagella-associated protein 161"
FT                   /id="PRO_0000244093"
FT   CONFLICT        177
FT                   /note="L -> M (in Ref. 1; BAB24555)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   303 AA;  34388 MW;  56FEC3AD8DCEBC97 CRC64;
     MAQNVYGPGV RMGNWNEDVY LEEERMRHFL EKREKGELLI QRNRRVKKNI LRPMQLSVSE
     DGYVHYGDKV IIVNPDQVLG EEAGKFMRGD LSLCMSPDEV KAQLSDDLEI PCGVSAVQTI
     APMGRNTFTI LSDGANSCEM GQVVVYGQNF CLGIAAGLEG KMLYLTSDHR TLLKSSLKSG
     LQEVTLTDEV THLNCWQAAF LDPQLRLEYE GFPVRANEKI VIYHRHTNRA LAVHRNLFLR
     TYFGKEMEVV AHTYLDSHKV EKPKNQWMLV TGNPRNKSNT MLDISKPITE DTRALEQAMG
     INT