ID   CF176_HUMAN             Reviewed;         186 AA.
AC   A8K010;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Putative transcriptional regulator encoded by LINC00473;
GN   Name=LINC00473; Synonyms=C6orf176;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Adrenal gland;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=22108211; DOI=10.1152/physiolgenomics.00089.2011;
RA   Reitmair A., Sachs G., Im W.B., Wheeler L.;
RT   "C6orf176: a novel possible regulator of cAMP-mediated gene expression.";
RL   Physiol. Genomics 44:152-161(2012).
CC   -!- FUNCTION: May play a role in cAMP-mediated gene transcription.
CC       {ECO:0000269|PubMed:22108211}.
CC   -!- INDUCTION: Up-regulated upon activation of cAMP signaling.
CC       {ECO:0000269|PubMed:22108211}.
CC   -!- CAUTION: Product of a dubious CDS prediction. May be a non-coding RNA.
CC       According to PubMed:22108211, silencing of that gene results in altered
CC       transcription of cAMP-responsive genes. However, PubMed:22108211 does
CC       not provide evidence that it is due to the absence of the putative
CC       protein. {ECO:0000305}.
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DR   EMBL; AK289375; BAF82064.1; -; mRNA.
DR   EMBL; BC008632; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; A8K010; -.
DR   BioMuta; HGNC:21160; -.
DR   MassIVE; A8K010; -.
DR   PeptideAtlas; A8K010; -.
DR   PRIDE; A8K010; -.
DR   ProteomicsDB; 1830; -.
DR   GeneCards; LINC00473; -.
DR   HGNC; HGNC:21160; LINC00473.
DR   neXtProt; NX_A8K010; -.
DR   Pharos; A8K010; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; A8K010; protein.
DR   GO; GO:0006351; P:transcription, DNA-templated; IMP:UniProtKB.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..186
FT                   /note="Putative transcriptional regulator encoded by
FT                   LINC00473"
FT                   /id="PRO_0000317269"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        30
FT                   /note="R -> Q (in Ref. 1; BAF82064)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   186 AA;  21118 MW;  6CC5BF8FDA023616 CRC64;
     MELSAAAGRR RQAPWREFTG RHRTERSQER GSTPRKERSM GSRQPRKRER EPRDCTPTCT
     NAASVSRSGA RRAPGCAGRC ITMKNCARAW RELSERACCF QAVPPSNMKQ SWLIFLDTTL
     CSAWLLASSC PRLYAPLISF HCMCFNTVLL FPRLFGPTLS AKIQFNTDLS LRAIAWKCTK
     DTTTYC