CF201_HUMAN
ID CF201_HUMAN Reviewed; 140 AA.
AC Q7Z4U5; A6NLI6; Q6NXN5;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 3.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Uncharacterized protein C6orf201;
GN Name=C6orf201;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS PRO-20 AND
RP LYS-117.
RA Guo J.H., Yu L.;
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP PRO-20 AND LYS-117.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q7Z4U5-3; O00303: EIF3F; NbExp=3; IntAct=EBI-18680706, EBI-711990;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7Z4U5-2; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z4U5-3; Sequence=VSP_040789, VSP_040790;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
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DR EMBL; AF429972; AAP97304.1; -; mRNA.
DR EMBL; AL033383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC047663; AAH47663.1; -; mRNA.
DR EMBL; BC066986; AAH66986.1; -; mRNA.
DR RefSeq; NP_001078870.1; NM_001085401.2. [Q7Z4U5-2]
DR AlphaFoldDB; Q7Z4U5; -.
DR BioGRID; 135654; 13.
DR IntAct; Q7Z4U5; 4.
DR STRING; 9606.ENSP00000420610; -.
DR PhosphoSitePlus; Q7Z4U5; -.
DR BioMuta; C6orf201; -.
DR DMDM; 327478579; -.
DR PaxDb; Q7Z4U5; -.
DR PeptideAtlas; Q7Z4U5; -.
DR PRIDE; Q7Z4U5; -.
DR DNASU; 404220; -.
DR GeneID; 404220; -.
DR UCSC; uc003mwa.5; human. [Q7Z4U5-2]
DR CTD; 404220; -.
DR GeneCards; C6orf201; -.
DR HGNC; HGNC:21620; C6orf201.
DR neXtProt; NX_Q7Z4U5; -.
DR PharmGKB; PA134906041; -.
DR VEuPathDB; HostDB:ENSG00000185689; -.
DR eggNOG; ENOG502S904; Eukaryota.
DR HOGENOM; CLU_136293_0_0_1; -.
DR InParanoid; Q7Z4U5; -.
DR OMA; GISEPTW; -.
DR OrthoDB; 1234300at2759; -.
DR PhylomeDB; Q7Z4U5; -.
DR TreeFam; TF341213; -.
DR PathwayCommons; Q7Z4U5; -.
DR SignaLink; Q7Z4U5; -.
DR BioGRID-ORCS; 404220; 5 hits in 1044 CRISPR screens.
DR ChiTaRS; C6orf201; human.
DR GenomeRNAi; 404220; -.
DR Pharos; Q7Z4U5; Tdark.
DR PRO; PR:Q7Z4U5; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q7Z4U5; protein.
DR Genevisible; Q7Z4U5; HS.
DR InterPro; IPR027827; DUF4523.
DR PANTHER; PTHR35968; PTHR35968; 1.
DR Pfam; PF15023; DUF4523; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..140
FT /note="Uncharacterized protein C6orf201"
FT /id="PRO_0000297587"
FT VAR_SEQ 1..29
FT /note="MLSNLHELLPNHLMETLYSRKSEEDKKKC -> MASGPLGPGARPTRLHPPF
FT PPPAHIKPGAPPG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040789"
FT VAR_SEQ 128..140
FT /note="GKSQCLLGISEPT -> E (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040790"
FT VARIANT 20
FT /note="R -> P (in dbSNP:rs619483)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_056805"
FT VARIANT 25
FT /note="D -> Y (in dbSNP:rs9503910)"
FT /id="VAR_056806"
FT VARIANT 117
FT /note="N -> K (in dbSNP:rs643232)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_064769"
SQ SEQUENCE 140 AA; 16243 MW; 86EEFD95FB623A21 CRC64;
MLSNLHELLP NHLMETLYSR KSEEDKKKCE NPELSGLERI LARHQLPKEI NLTPKPNRMP
PWKRKIINNV TDGWKKCHLL KRNTKEPPMS TIVVRKLIQK NVPRRHSLRN TSRKLRNLPT
TAKGTQTGKS QCLLGISEPT
