ID   CF206_BOVIN             Reviewed;         622 AA.
AC   Q29RL1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Cilia- and flagella-associated protein 206 {ECO:0000305};
GN   Name=CFAP206 {ECO:0000250|UniProtKB:Q8IYR0};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for sperm motility and is involved in the
CC       regulation of the beating frequency of motile cilia on the epithelial
CC       cells of the respiratory tract (By similarity). Required for the
CC       establishment of radial spokes in sperm flagella (By similarity).
CC       {ECO:0000250|UniProtKB:Q6PE87}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q6PE87}. Cytoplasm, cytoskeleton, cilium basal
CC       body {ECO:0000250|UniProtKB:Q6PE87}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q29RL1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q29RL1-2; Sequence=VSP_036123;
CC   -!- SIMILARITY: Belongs to the CFAP206 family. {ECO:0000305}.
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DR   EMBL; AAFC03120816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC114126; AAI14127.1; -; mRNA.
DR   RefSeq; NP_001039602.1; NM_001046137.2. [Q29RL1-2]
DR   RefSeq; XP_005210949.1; XM_005210892.3. [Q29RL1-1]
DR   AlphaFoldDB; Q29RL1; -.
DR   SMR; Q29RL1; -.
DR   STRING; 9913.ENSBTAP00000018677; -.
DR   PaxDb; Q29RL1; -.
DR   Ensembl; ENSBTAT00000018677; ENSBTAP00000018677; ENSBTAG00000014054. [Q29RL1-1]
DR   Ensembl; ENSBTAT00000046847; ENSBTAP00000044094; ENSBTAG00000014054. [Q29RL1-2]
DR   GeneID; 513096; -.
DR   KEGG; bta:513096; -.
DR   CTD; 154313; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014054; -.
DR   eggNOG; ENOG502QTGJ; Eukaryota.
DR   GeneTree; ENSGT00390000016036; -.
DR   HOGENOM; CLU_030061_0_0_1; -.
DR   InParanoid; Q29RL1; -.
DR   OMA; LHDTVRY; -.
DR   OrthoDB; 357137at2759; -.
DR   TreeFam; TF323439; -.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000014054; Expressed in spermatid and 39 other tissues.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR   GO; GO:0001534; C:radial spoke; ISS:UniProtKB.
DR   GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   GO; GO:0003356; P:regulation of cilium beat frequency; ISS:UniProtKB.
DR   GO; GO:1901317; P:regulation of flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR   InterPro; IPR021897; FAP206.
DR   PANTHER; PTHR21442; PTHR21442; 1.
DR   Pfam; PF12018; FAP206; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell projection; Cilium;
KW   Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..622
FT                   /note="Cilia- and flagella-associated protein 206"
FT                   /id="PRO_0000358909"
FT   VAR_SEQ         281..320
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_036123"
SQ   SEQUENCE   622 AA;  71079 MW;  1D92E8EBA6DB627B CRC64;
     MPPTQAESVI KNIIREIGQE CAAHGEIVPE TLVAFMVKAV VLDPSNGFNT DRTLTKSDVQ
     KLVKLCVNRL LDSKNPSLDT IKMQVYFDMN YTSREEFLEE HHQVIESRLS SVSREITDSR
     ACVREELESL YRKIVSYVLL RSGLGSPTDI KIVREATAAL QSVFPQTELG TFLTLSKKDK
     ERQLKELTMI VTGIRLFNRD CGKGGEGIDD LPAILQEAIP ATTQHVDSQL EVVQEQAYRY
     TAILEKVAKN PLMSQELQPY MLREALYNVR QCEIFLQVIL SDIITCAQEV EMMIKQLEAQ
     LEQLKLTVKS KTAVPTSQVF PIFIALSNLW TSFQDETVLI SILSNLTTHL EPFLGAHDLF
     FPEKVMQVLL DGVTVKTDVC RIKEHIEDKV NVADFKKLEW LFPETTANFD KLLIQYRGFC
     AYTFATTDGL LLPGNPSIGI LKYKDKYYTF NTRDAAYSFA ENPENYIDII REKAKRNAEL
     IQLLELHQQF ESLIQYSQMK EVDKRYIKPI TKCETGTQTD THLLPPTIVR SYEWNEWELR
     RKAIKLANLR RKVTHSVQTD HSHMRRENCS QVYPSKDVGT QSMREGSSRV PRPQIYIAGL
     RGGQTKTTYG VKVNLTRAVD ET