CF206_DANRE
ID CF206_DANRE Reviewed; 624 AA.
AC A2RV06; Q1JPX5; Q6TH38;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Cilia- and flagella-associated protein 206 {ECO:0000305};
GN Name=cfap206; ORFNames=zgc:109719, zgc:136502;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney marrow;
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential for sperm motility and is involved in the
CC regulation of the beating frequency of motile cilia on the epithelial
CC cells of the respiratory tract (By similarity). Required for the
CC establishment of radial spokes in sperm flagella (By similarity).
CC {ECO:0000250|UniProtKB:Q6PE87}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q6PE87}. Cytoplasm, cytoskeleton, cilium basal
CC body {ECO:0000250|UniProtKB:Q6PE87}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2RV06-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2RV06-2; Sequence=VSP_036200;
CC -!- SIMILARITY: Belongs to the CFAP206 family. {ECO:0000305}.
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DR EMBL; AY398318; AAQ97751.1; -; mRNA.
DR EMBL; BC116562; AAI16563.1; -; mRNA.
DR EMBL; BC133124; AAI33125.1; -; mRNA.
DR RefSeq; NP_991180.1; NM_205617.1.
DR AlphaFoldDB; A2RV06; -.
DR STRING; 7955.ENSDARP00000033381; -.
DR PaxDb; A2RV06; -.
DR PeptideAtlas; A2RV06; -.
DR Ensembl; ENSDART00000036373; ENSDARP00000033381; ENSDARG00000021997. [A2RV06-1]
DR GeneID; 402910; -.
DR KEGG; dre:402910; -.
DR CTD; 154313; -.
DR ZFIN; ZDB-GENE-050522-460; cfap206.
DR eggNOG; ENOG502QTGJ; Eukaryota.
DR GeneTree; ENSGT00390000016036; -.
DR HOGENOM; CLU_030061_0_0_1; -.
DR InParanoid; A2RV06; -.
DR OMA; LHDTVRY; -.
DR OrthoDB; 357137at2759; -.
DR PhylomeDB; A2RV06; -.
DR TreeFam; TF323439; -.
DR PRO; PR:A2RV06; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000021997; Expressed in testis and 8 other tissues.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IDA:ZFIN.
DR GO; GO:0001534; C:radial spoke; ISS:UniProtKB.
DR GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR GO; GO:0003356; P:regulation of cilium beat frequency; ISS:UniProtKB.
DR GO; GO:1901317; P:regulation of flagellated sperm motility; ISS:UniProtKB.
DR GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR InterPro; IPR021897; FAP206.
DR PANTHER; PTHR21442; PTHR21442; 1.
DR Pfam; PF12018; FAP206; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium;
KW Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..624
FT /note="Cilia- and flagella-associated protein 206"
FT /id="PRO_0000360149"
FT VAR_SEQ 202..211
FT /note="GEGGEAIQSL -> V (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_036200"
FT CONFLICT 221
FT /note="G -> R (in Ref. 2; AAI16563)"
FT /evidence="ECO:0000305"
FT CONFLICT 246
FT /note="L -> Q (in Ref. 1; AAQ97751)"
FT /evidence="ECO:0000305"
FT CONFLICT 393
FT /note="S -> L (in Ref. 2; AAI16563)"
FT /evidence="ECO:0000305"
FT CONFLICT 400
FT /note="E -> D (in Ref. 1; AAQ97751)"
FT /evidence="ECO:0000305"
FT CONFLICT 503
FT /note="T -> R (in Ref. 2; AAI16563)"
FT /evidence="ECO:0000305"
FT CONFLICT 594
FT /note="E -> Q (in Ref. 1; AAQ97751)"
FT /evidence="ECO:0000305"
FT CONFLICT 601
FT /note="Q -> K (in Ref. 2; AAI16563)"
FT /evidence="ECO:0000305"
FT CONFLICT 606
FT /note="S -> G (in Ref. 1; AAQ97751 and 2; AAI16563)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 624 AA; 69904 MW; 59FD8FCBDC666030 CRC64;
MSSSQAEGVI RNIIREISQT CLSRGQTLSE TLIAFMVKAV VLDPTNHFNV DRTLTKQDVQ
KLIELCVDRL MDQTSPTLQT IKMQVYFDMN YTPRREFLEM QQKLLQSRLQ SLSREITDSR
AKSREDLKKL YGTIVHYIIQ SSNLSSSTDI NTVRETTAAL QSIFPPSQLG SFMSLLKSDK
EQQLKENSLI VSGIRLFNKD NGEGGEAIQS LPSILNEKLP GVVSDLEREL ASCERLCWQY
TGLLELISER DTAHSQSPVP PRLLTQALYN TRQHEAFLRL TLADVILCAQ EVTRLQSDLM
SRMTLLRDAI HTKTTVPTTH VFPHFSAVGR LWAGLEQEML LLSMLTNVAS GLRVFLTAES
LLTPDQMELP VRTDADRCSG TAEERVLVSE TSSCECCFPE STADFQHLPL QYNGFCGVAL
VDRNGLLLPG NTSIGVLKHK EKYYAFSSRS AAYEFSCRAD EYTAAVLETA SRTPELIQLL
QLQQHFTSST AYSQLPAGHQ SLTAGMPSGQ KLLLKSISKS DAGVQTEIHP LQSNICTSYE
WNEWEMRRKA IKLANLHSKV TRSSQSDWSL MRRHNSSQTF LPKDASCQTK RDGESLVPKA
QVYLSSLRGA AGFRKVDLSR AVDE
