ID   CF206_MACFA             Reviewed;         622 AA.
AC   Q95JU3; Q8HZY4;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Cilia- and flagella-associated protein 206 {ECO:0000305};
GN   Name=CFAP206 {ECO:0000250|UniProtKB:Q8IYR0};
GN   ORFNames=QtsA-12767, QtsA-18510;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: Essential for sperm motility and is involved in the
CC       regulation of the beating frequency of motile cilia on the epithelial
CC       cells of the respiratory tract (By similarity). Required for the
CC       establishment of radial spokes in sperm flagella (By similarity).
CC       {ECO:0000250|UniProtKB:Q6PE87}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q6PE87}. Cytoplasm, cytoskeleton, cilium basal
CC       body {ECO:0000250|UniProtKB:Q6PE87}.
CC   -!- SIMILARITY: Belongs to the CFAP206 family. {ECO:0000305}.
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DR   EMBL; AB070085; BAB63030.1; -; mRNA.
DR   EMBL; AB096998; BAC41245.1; -; mRNA.
DR   RefSeq; NP_001271486.1; NM_001284557.1.
DR   RefSeq; XP_015304320.1; XM_015448834.1.
DR   RefSeq; XP_015304321.1; XM_015448835.1.
DR   AlphaFoldDB; Q95JU3; -.
DR   STRING; 9541.XP_005552462.1; -.
DR   GeneID; 102133782; -.
DR   CTD; 154313; -.
DR   VEuPathDB; HostDB:ENSMFAG00000035889; -.
DR   eggNOG; ENOG502QTGJ; Eukaryota.
DR   OMA; LHDTVRY; -.
DR   Proteomes; UP000233100; Chromosome 4.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR   GO; GO:0001534; C:radial spoke; ISS:UniProtKB.
DR   GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   GO; GO:0003356; P:regulation of cilium beat frequency; ISS:UniProtKB.
DR   GO; GO:1901317; P:regulation of flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR   InterPro; IPR021897; FAP206.
DR   PANTHER; PTHR21442; PTHR21442; 1.
DR   Pfam; PF12018; FAP206; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Reference proteome.
FT   CHAIN           1..622
FT                   /note="Cilia- and flagella-associated protein 206"
FT                   /id="PRO_0000089554"
FT   REGION          571..592
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..588
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        326
FT                   /note="L -> P (in Ref. 1; BAC41245)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   622 AA;  71148 MW;  EC2E1B28019554B0 CRC64;
     MPPTQAESVI RSIIREIGQE CAAHGEIVSE TLIAFMVKAV VLDPSNGFNM DRTLMKSDVQ
     NLVKLCMTRL LDTKNPSLDT IKMQVYFDMN YTNRVEFLEE HHRVLESRLG SVTREITDNR
     ACAKEELESL YRKIISYVLL RSGLGSPTDI KTVREVTAAL QSIFPQAELG TFLTLSKKDK
     ERQLKELTMI VTGIRLFNRD CGKGGEGIDD LPAVLHVAIP ATMQHIDYQL ETARSQVYRY
     TAILEKAAND PHMRAELQPY MLKEALYNIR QYEVFLQIIL SDIITGAQEV EMMTKQLGAH
     LEQLKMTIKS KTAVPTSQVF PIFIALSTLW TSLQDETIVV GVLSNLFTHI QPFLGAHELY
     FPERAMQRHL NGATVKTDVC RMKEHMEDRV NVADFRKLEW LFPETTANFD KLLIQYRGFC
     AYTFAATDGL LLPGNPAIGI LKYKEKYYTF NSKDAAYSFA ENPEHYIDIV REKAKKNTEL
     IQLLELHQQF ETLIPYSQMR DADKHYIKPI TKCESSTQTD THILPPTIVR SYEWNEWELR
     RKAIKLANLH QKVTHSVQTD LSHLRRENCS QVYPPKDTST QSMREDSTGV PRPQIYLAGL
     RGGKSEITDE VKVNLTRAVD ET