ID   CF206_RAT               Reviewed;         622 AA.
AC   A1A5Q4;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Cilia- and flagella-associated protein 206 {ECO:0000305};
GN   Name=Cfap206 {ECO:0000312|RGD:1310641};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Essential for sperm motility and is involved in the
CC       regulation of the beating frequency of motile cilia on the epithelial
CC       cells of the respiratory tract (By similarity). Required for the
CC       establishment of radial spokes in sperm flagella (By similarity).
CC       {ECO:0000250|UniProtKB:Q6PE87}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:Q6PE87}. Cytoplasm, cytoskeleton, cilium basal
CC       body {ECO:0000250|UniProtKB:Q6PE87}.
CC   -!- SIMILARITY: Belongs to the CFAP206 family. {ECO:0000305}.
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DR   EMBL; AABR03041439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03043392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC128759; AAI28760.1; -; mRNA.
DR   RefSeq; NP_001073169.1; NM_001079701.1.
DR   RefSeq; XP_017449021.1; XM_017593532.1.
DR   AlphaFoldDB; A1A5Q4; -.
DR   SMR; A1A5Q4; -.
DR   STRING; 10116.ENSRNOP00000045325; -.
DR   PaxDb; A1A5Q4; -.
DR   PRIDE; A1A5Q4; -.
DR   Ensembl; ENSRNOT00000051243; ENSRNOP00000045325; ENSRNOG00000009061.
DR   GeneID; 366347; -.
DR   KEGG; rno:366347; -.
DR   UCSC; RGD:1310641; rat.
DR   CTD; 154313; -.
DR   RGD; 1310641; Cfap206.
DR   eggNOG; ENOG502QTGJ; Eukaryota.
DR   GeneTree; ENSGT00390000016036; -.
DR   HOGENOM; CLU_030061_0_0_1; -.
DR   InParanoid; A1A5Q4; -.
DR   OMA; LHDTVRY; -.
DR   OrthoDB; 357137at2759; -.
DR   PhylomeDB; A1A5Q4; -.
DR   TreeFam; TF323439; -.
DR   PRO; PR:A1A5Q4; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000009061; Expressed in testis and 3 other tissues.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR   GO; GO:0001534; C:radial spoke; ISS:UniProtKB.
DR   GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   GO; GO:0003356; P:regulation of cilium beat frequency; ISS:UniProtKB.
DR   GO; GO:1901317; P:regulation of flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR   InterPro; IPR021897; FAP206.
DR   PANTHER; PTHR21442; PTHR21442; 1.
DR   Pfam; PF12018; FAP206; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Reference proteome.
FT   CHAIN           1..622
FT                   /note="Cilia- and flagella-associated protein 206"
FT                   /id="PRO_0000358911"
SQ   SEQUENCE   622 AA;  70835 MW;  4E941338644624BE CRC64;
     MPPTQAESVI KNIIREIGQE CAAHGEITSE TVVAFMVKAV VLDPSNGFNM DRTLVKTDVQ
     KLVKLCVARL LDNKNPSLDT IKMQVYFDMN YTSREDFLEE HHRVLESRLG IVSREITDTR
     ACAKEELENL YRKIVSYVLL RSGLGSPTDI KIVREATAAL QSVFPQAELC TFLTLSKKDK
     ERQLKELTMI VTGIRLFNRD CGKGGEGIDD LPAILLEAIP ATTHHIDSQL QIAQEQAFRY
     TAIIEKVTNN PLMAKELQPY MLKEALYNVR QYEIFLQTVL SDIITCAEEV ELMTKQLAAQ
     LEQLKMTVKS KTAVPTSQVF PIFIALASLW TSFQDETVLI SVLSNLTTNL ELFLGTHDLL
     FPEKVMQGLL DGVIVKTDMT RIEEHLEEKV QLADFRVLEW LFPETTANFN KLLIQYRGFC
     GYTFAVTDGL LLPGNPTIGI LKYKEKYYTF NSRDAAYSFA ENPDHYINLI KEKAKKNAEL
     IQLLELHQQF ETLIPYSQMK DVDKHFIKPI TKCENGTQTD THILPPTIVR SYEWNEWELR
     RKAIQLANLR QKMTHSVQTD LSHMRRDNAS QVYPLKEVGT QSKREGSTRV PRPQIFIAGL
     RGGQSKTTHG VKINLTRAVD ET