ID   CF206_TETTS             Reviewed;         635 AA.
AC   Q23H79;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Cilia- and flagella-associated protein 206 {ECO:0000305};
DE   AltName: Full=Flagella-associated protein 206 {ECO:0000303|PubMed:25540426};
GN   Name=CFAP206 {ECO:0000250|UniProtKB:Q8IYR0};
GN   Synonyms=FAP206 {ECO:0000303|PubMed:25540426};
GN   ORFNames=TTHERM_00820660 {ECO:0000312|EMBL:EAR95929.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210;
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25540426; DOI=10.1091/mbc.e14-11-1506;
RA   Vasudevan K.K., Song K., Alford L.M., Sale W.S., Dymek E.E., Smith E.F.,
RA   Hennessey T., Joachimiak E., Urbanska P., Wloga D., Dentler W.,
RA   Nicastro D., Gaertig J.;
RT   "FAP206 is a microtubule-docking adapter for ciliary radial spoke 2 and
RT   dynein c.";
RL   Mol. Biol. Cell 26:696-710(2015).
CC   -!- FUNCTION: May regulate cilium motility through its role in the assembly
CC       of the axonemal RS2 radial spoke. {ECO:0000269|PubMed:25540426}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:25540426}.
CC   -!- DISRUPTION PHENOTYPE: The mobility of cells lacking CFAP206 is
CC       decreased. If their number is normal, cilia are slightly longer and
CC       display uncoordinated motility with abnormal waveform characterized by
CC       decreased bend amplitude and decreased metachronal coordination. Cilia
CC       axonemes display a classical 9+2 organization of microtubules but their
CC       shape is abnormal. {ECO:0000269|PubMed:25540426}.
CC   -!- SIMILARITY: Belongs to the CFAP206 family. {ECO:0000305}.
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DR   EMBL; GG662700; EAR95929.1; -; Genomic_DNA.
DR   RefSeq; XP_001016174.1; XM_001016174.1.
DR   AlphaFoldDB; Q23H79; -.
DR   SMR; Q23H79; -.
DR   STRING; 5911.EAR95929; -.
DR   EnsemblProtists; EAR95929; EAR95929; TTHERM_00820660.
DR   GeneID; 7838391; -.
DR   KEGG; tet:TTHERM_00820660; -.
DR   eggNOG; ENOG502QTGJ; Eukaryota.
DR   HOGENOM; CLU_030061_0_0_1; -.
DR   InParanoid; Q23H79; -.
DR   OMA; LHDTVRY; -.
DR   OrthoDB; 357137at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0031514; C:motile cilium; IDA:UniProtKB.
DR   GO; GO:0001534; C:radial spoke; IDA:UniProtKB.
DR   GO; GO:0035082; P:axoneme assembly; IMP:UniProtKB.
DR   GO; GO:0048870; P:cell motility; IMP:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; IMP:UniProtKB.
DR   InterPro; IPR021897; FAP206.
DR   PANTHER; PTHR21442; PTHR21442; 1.
DR   Pfam; PF12018; FAP206; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Reference proteome.
FT   CHAIN           1..635
FT                   /note="Cilia- and flagella-associated protein 206"
FT                   /id="PRO_0000437483"
SQ   SEQUENCE   635 AA;  73490 MW;  5CB72B182BED9506 CRC64;
     MNQLEEIVKY VIYKCRENNH PVTETLAAFV TQTIYNPKTD RFYLEDKLTA SQVDELKATV
     LQKLSQIDKP NMKTIQMQIS YDSAYIESEI QRQERIKNQS IETGKLTDEV VSLEIKNAKD
     FEGLTVLFKK IFNFLLYKNK ELMYDGTNKT GNQDSENQAT QFNIEKEVAA GLESVIPRAA
     LGPFVSLNPS EKVTQLVELS NLVIGIRLFN KWIQKGGIGL VPFQDLLEYE GRDLIERIRQ
     EAFEVIENCD NYTIFFQNVG PGKIKISDEQ FKQYKDELTF LRQYLSYILS IQEDVDISEN
     SVDSNQTRYL KEIKDLETLL KQKSSAPKEQ VYPKFATLAQ AYIQLLEEKK LCLTRVKLFE
     LLQEMRKGFK LTLPRNLILT AKNISQDPSN EEQVEIEYSE DCGIERLLPK NTPDFMQTPL
     DYLGFCLWSI VKRDGLLLPG KPALGVFRYK DKNCVFSDEK SINEFLSDPQ QFIQGVINQC
     RKNPELIHLL RMDDSFKNVN LNIYVSGQEG GHQLSNKLMV DKGIETPLHF VEKRLDPNYC
     WNEWELRKKA LQMANIRKRQ TKACQTILSN FKVDSEAQTY LPKDNETNTG KTEWDIRKFA
     IEQAKKKGII AGTDRAPYPI HPRNYITGLR DKDTN