ID   CF210_BOVIN             Reviewed;         547 AA.
AC   E1BJL9;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   10-APR-2019, sequence version 3.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Cilia- and flagella- associated protein 210;
GN   Name=CFAP210 {ECO:0000312|VGNC:VGNC:26870}; Synonyms=CCDC173;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000312|Proteomes:UP000009136};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0007744|PDB:7RRO}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA   Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA   Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA   Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT   "De novo identification of mammalian ciliary motility proteins using cryo-
RT   EM.";
RL   Cell 184:5791-5806.e19(2021).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. {ECO:0000269|PubMed:34715025}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:34715025}.
CC   -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC       {ECO:0000269|PubMed:34715025}.
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DR   PDB; 7RRO; EM; 3.40 A; o/p=1-547.
DR   PDBsum; 7RRO; -.
DR   SMR; E1BJL9; -.
DR   STRING; 9913.ENSBTAP00000044199; -.
DR   PaxDb; E1BJL9; -.
DR   PRIDE; E1BJL9; -.
DR   Ensembl; ENSBTAT00000046952.4; ENSBTAP00000044199.4; ENSBTAG00000001090.5.
DR   VEuPathDB; HostDB:ENSBTAG00000001090; -.
DR   VGNC; VGNC:26870; CFAP210.
DR   eggNOG; ENOG502QPZ3; Eukaryota.
DR   GeneTree; ENSGT00730000111149; -.
DR   HOGENOM; CLU_036492_1_0_1; -.
DR   InParanoid; E1BJL9; -.
DR   OMA; AKKEMHF; -.
DR   TreeFam; TF328736; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000001090; Expressed in semen and 81 other tissues.
DR   GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR   InterPro; IPR039986; CFAP210.
DR   InterPro; IPR043597; TPH_dom.
DR   PANTHER; PTHR28663; PTHR28663; 1.
DR   Pfam; PF13868; TPH; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..547
FT                   /note="Cilia- and flagella- associated protein 210"
FT                   /id="PRO_0000456162"
FT   COILED          184..254
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   547 AA;  65300 MW;  5FAB665D1F26D323 CRC64;
     MLVRFGRRSG QAKESAEMKN CEEDPVLYPP LLPTKVDLRQ VTIIPHNEWE RIRDSLDSLT
     REAACLRAER KAKKEMHLRS QEVVKHWTNT YAGMKEQKLE AKKKRDEEIE AERQILDIEE
     AIYKQGERKK AIELAKQYQF YQTERVKNFH SGLLLSRVMK ERDAQIEFQK SKIKSDKKWE
     EQVKLNVEKA FKEEREKAEK QRRERVALAK DHLKQIKEHE EEEERRRKEE EKDAEEIKRQ
     NSLYEIEMKK KQGKKKEEIN ESRRLFFEHL NDKHIIKAVE QQQQEEEDEK IRKFIKAKKR
     LTQMGKEKEA ETHRLMEERR KRINNFLSKL MKEKFDNEDL IIARDIAEAE AEWEKREREK
     YEKNKAELKA IAEHRALVMK NKEEEERQRK IEATEQMLAI LKADQIFWEH EKEKKQKADK
     ERREVQDAHI QQMAKHKFNA LQAKQAESEY CRLTEALVAE KEKEFQDYAR EVIESESEST
     KKYIYPLVKA VQEGPGGGRG PVLVDRGGLR PSYQANDTTG VQLPFYNSPG SKYNNFQKSK
     GRLGFTW