CF210_HUMAN
ID CF210_HUMAN Reviewed; 552 AA.
AC Q0VFZ6; Q6PJF6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Cilia- and flagella- associated protein 210 {ECO:0000312|HGNC:HGNC:25064};
DE AltName: Full=Coiled-coil domain-containing protein 173;
GN Name=CFAP210 {ECO:0000312|HGNC:HGNC:25064}; Synonyms=C2orf77, CCDC173;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating. {ECO:0000250|UniProtKB:E1BJL9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:E1BJL9}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI17446.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC016772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015980; AAH15980.1; -; mRNA.
DR EMBL; BC117445; AAI17446.1; ALT_INIT; mRNA.
DR CCDS; CCDS46445.1; -.
DR RefSeq; NP_001078916.1; NM_001085447.1.
DR AlphaFoldDB; Q0VFZ6; -.
DR SMR; Q0VFZ6; -.
DR BioGRID; 126216; 5.
DR IntAct; Q0VFZ6; 4.
DR STRING; 9606.ENSP00000391504; -.
DR iPTMnet; Q0VFZ6; -.
DR PhosphoSitePlus; Q0VFZ6; -.
DR BioMuta; CCDC173; -.
DR DMDM; 327478499; -.
DR MassIVE; Q0VFZ6; -.
DR PaxDb; Q0VFZ6; -.
DR PeptideAtlas; Q0VFZ6; -.
DR PRIDE; Q0VFZ6; -.
DR ProteomicsDB; 58836; -.
DR Antibodypedia; 64630; 48 antibodies from 11 providers.
DR DNASU; 129881; -.
DR Ensembl; ENST00000447353.6; ENSP00000391504.1; ENSG00000154479.13.
DR GeneID; 129881; -.
DR KEGG; hsa:129881; -.
DR MANE-Select; ENST00000447353.6; ENSP00000391504.1; NM_001085447.2; NP_001078916.1.
DR UCSC; uc002ufe.3; human.
DR CTD; 129881; -.
DR GeneCards; CCDC173; -.
DR HGNC; HGNC:25064; CFAP210.
DR HPA; ENSG00000154479; Tissue enriched (testis).
DR neXtProt; NX_Q0VFZ6; -.
DR OpenTargets; ENSG00000154479; -.
DR VEuPathDB; HostDB:ENSG00000154479; -.
DR eggNOG; ENOG502QPZ3; Eukaryota.
DR GeneTree; ENSGT00730000111149; -.
DR HOGENOM; CLU_036492_1_0_1; -.
DR InParanoid; Q0VFZ6; -.
DR OMA; AKKEMHF; -.
DR OrthoDB; 994326at2759; -.
DR PhylomeDB; Q0VFZ6; -.
DR TreeFam; TF328736; -.
DR PathwayCommons; Q0VFZ6; -.
DR SignaLink; Q0VFZ6; -.
DR BioGRID-ORCS; 129881; 16 hits in 1078 CRISPR screens.
DR ChiTaRS; CCDC173; human.
DR GenomeRNAi; 129881; -.
DR Pharos; Q0VFZ6; Tdark.
DR PRO; PR:Q0VFZ6; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q0VFZ6; protein.
DR Bgee; ENSG00000154479; Expressed in sperm and 110 other tissues.
DR ExpressionAtlas; Q0VFZ6; baseline and differential.
DR Genevisible; Q0VFZ6; HS.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR InterPro; IPR039986; CFAP210.
DR InterPro; IPR043597; TPH_dom.
DR PANTHER; PTHR28663; PTHR28663; 1.
DR Pfam; PF13868; TPH; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..552
FT /note="Cilia- and flagella- associated protein 210"
FT /id="PRO_0000318846"
FT REGION 216..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 53..143
FT /evidence="ECO:0000255"
FT COILED 186..307
FT /evidence="ECO:0000255"
FT COILED 348..409
FT /evidence="ECO:0000255"
FT COILED 460..488
FT /evidence="ECO:0000255"
SQ SEQUENCE 552 AA; 66403 MW; A727A02E40660938 CRC64;
MDTSSEMLVR FGRRCGRAKE STEIRNSEED QVLYLPLLPS KVDLQQVTII PHDEWKRIQD
SLDRLTREAA CLRAERKAKK EMHLRSQEVV KHWTNTYAGM KEQKLEAKKK RDEEIEAERQ
ILDLEEEIYK QGKRKKAIEN AKQYQFYQTE RVKNFHSGLL LSRVMKERDA QIEFRKSKIK
SDKKWEEQLK LNIEKAFKEE QEKAEKRHRE RVALAKDHLK QIKEHEEEEE RRKKYEEKDA
EEIKRQNALY EIEMRKKLEK KREEMHESRR RFLEHMQDKH IIKAVEQQQQ EEEDEKMRKF
IKAKKRLIQM GKEKEAETHR LMEKRRERIH NFLSELLKEK LDNEDMIIAR DIAEAEAEWE
KREREKDEKN KAELKTIAEY RAIVMKNKEE EERQRKIEAK EQLLAVMKAD QIFWEHEKEK
KCKADKEHQE VQDAHIQQMA KNKFNAKQAK QAELDYCRLT EALVAEKEKE FQDYAREVIE
LESETTNKYI YPLVKAVQEG PGGGRGPVFV DRGGLRPSYQ ANDVTGVQLP FYNSQGPKYN
FQKSKRRLGF TW
