ID   CF210_MOUSE             Reviewed;         547 AA.
AC   A0JLY1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Cilia- and flagella- associated protein 210;
DE   AltName: Full=Coiled-coil domain-containing protein 173;
GN   Name=Cfap210; Synonyms=Ccdc173;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating. {ECO:0000250|UniProtKB:E1BJL9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:E1BJL9}.
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DR   EMBL; AL845261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC125570; AAI25571.1; -; mRNA.
DR   EMBL; BC132491; AAI32492.1; -; mRNA.
DR   CCDS; CCDS38138.1; -.
DR   RefSeq; NP_001071152.1; NM_001077684.1.
DR   AlphaFoldDB; A0JLY1; -.
DR   SMR; A0JLY1; -.
DR   BioGRID; 217180; 2.
DR   STRING; 10090.ENSMUSP00000092548; -.
DR   PhosphoSitePlus; A0JLY1; -.
DR   MaxQB; A0JLY1; -.
DR   PaxDb; A0JLY1; -.
DR   PRIDE; A0JLY1; -.
DR   ProteomicsDB; 265583; -.
DR   Antibodypedia; 64630; 48 antibodies from 11 providers.
DR   Ensembl; ENSMUST00000094942; ENSMUSP00000092548; ENSMUSG00000070883.
DR   GeneID; 75051; -.
DR   KEGG; mmu:75051; -.
DR   UCSC; uc008jyo.1; mouse.
DR   CTD; 75051; -.
DR   MGI; MGI:1923100; Ccdc173.
DR   VEuPathDB; HostDB:ENSMUSG00000070883; -.
DR   eggNOG; ENOG502QPZ3; Eukaryota.
DR   GeneTree; ENSGT00730000111149; -.
DR   HOGENOM; CLU_036492_1_0_1; -.
DR   InParanoid; A0JLY1; -.
DR   OMA; AKKEMHF; -.
DR   OrthoDB; 994326at2759; -.
DR   PhylomeDB; A0JLY1; -.
DR   TreeFam; TF328736; -.
DR   BioGRID-ORCS; 75051; 1 hit in 73 CRISPR screens.
DR   ChiTaRS; Ccdc173; mouse.
DR   PRO; PR:A0JLY1; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; A0JLY1; protein.
DR   Bgee; ENSMUSG00000070883; Expressed in seminiferous tubule of testis and 164 other tissues.
DR   Genevisible; A0JLY1; MM.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   InterPro; IPR039986; CFAP210.
DR   InterPro; IPR043597; TPH_dom.
DR   PANTHER; PTHR28663; PTHR28663; 1.
DR   Pfam; PF13868; TPH; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..547
FT                   /note="Cilia- and flagella- associated protein 210"
FT                   /id="PRO_0000318847"
FT   REGION          214..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          50..131
FT                   /evidence="ECO:0000255"
FT   COILED          183..251
FT                   /evidence="ECO:0000255"
FT   COILED          342..405
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   547 AA;  65132 MW;  67883BA58DCD7F9C CRC64;
     MQVRFGRRSG QAKESQGMDC FEKEEIPYPP LLPSKVDLQQ ITIIPHAEWE RIRDSLNRLT
     REAAVLRAER AAKKKMHVKS QELVKHWTNT YAGMKEQKLK AKQKRDEEIE AERKVLDLEE
     EIYKEGERKK AIESARQCQF HQTERVKRFH SGLLLSRVMK ERDVQIQYKK NAVKSDKKWE
     EQVKLNDEKA FKEDQEKEEK RRRERVALAE DHLKQIEEHK EEEEARKKSE EKDAEEMKRQ
     NLLYEIEMKK NLSKKQEEID TNRKLLLDNM HNKNIIRAVE QQQQEEEDEK IRKFIKAKKR
     LIQMRMDKDA ETHRLMEERR ERINNFLSKL IKEKLDTEDL IIARDISEAD AELEKREKEK
     HEKNQADLKA IAEYRASVMK NKEEEERQRK IEAKEQLQAV LKADKIFQEL EKEKSLKVTR
     EKLEIQDAHI QQIAINKYNA KQMKEEELDY WRLTDALTVE KEKEFEKYAR EVINFESEST
     KKYAYPMVKA VQEGVGGGRG PPFVGRGGIR PSYQATDATG VQLPCFKSQG SKYNDFQKSK
     RRLGFTW