CF251_HUMAN
ID CF251_HUMAN Reviewed; 1149 AA.
AC Q8TBY9; C9J1W2; Q8IYA3; Q8N898; Q8NDE7;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Cilia- and flagella-associated protein 251 {ECO:0000305};
DE AltName: Full=WD repeat-containing protein 66 {ECO:0000312|HGNC:HGNC:28506};
GN Name=CFAP251 {ECO:0000312|HGNC:HGNC:28506};
GN Synonyms=WDR66 {ECO:0000312|HGNC:HGNC:28506};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-1149 (ISOFORM 3).
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 186-1149 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP INVOLVEMENT IN SPGF33, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=30122540; DOI=10.1016/j.ajhg.2018.07.014;
RA Kherraf Z.E., Amiri-Yekta A., Dacheux D., Karaouzene T., Coutton C.,
RA Christou-Kent M., Martinez G., Landrein N., Le Tanno P.,
RA Fourati Ben Mustapha S., Halouani L., Marrakchi O., Makni M., Latrous H.,
RA Kharouf M., Pernet-Gallay K., Gourabi H., Robinson D.R., Crouzy S.,
RA Blum M., Thierry-Mieg N., Toure A., Zouari R., Arnoult C., Bonhivers M.,
RA Ray P.F.;
RT "A Homozygous Ancestral SVA-Insertion-Mediated Deletion in WDR66 Induces
RT Multiple Morphological Abnormalities of the Sperm Flagellum and Male
RT Infertility.";
RL Am. J. Hum. Genet. 103:400-412(2018).
RN [6]
RP INVOLVEMENT IN SPGF33, VARIANT SPGF33 111-GLU--GLN-1149 DEL, FUNCTION,
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=30122541; DOI=10.1016/j.ajhg.2018.07.013;
RA Auguste Y., Delague V., Desvignes J.P., Longepied G., Gnisci A.,
RA Besnier P., Levy N., Beroud C., Megarbane A., Metzler-Guillemain C.,
RA Mitchell M.J.;
RT "Loss of Calmodulin- and Radial-Spoke-Associated Complex Protein CFAP251
RT Leads to Immotile Spermatozoa Lacking Mitochondria and Infertility in
RT Men.";
RL Am. J. Hum. Genet. 103:413-420(2018).
CC -!- FUNCTION: Involved in spermatozoa motility (PubMed:30122540,
CC PubMed:30122541). May also regulate cilium motility through its role in
CC the assembly of the axonemal radial spokes (By similarity).
CC {ECO:0000250|UniProtKB:A8IRK7, ECO:0000250|UniProtKB:Q24DE2,
CC ECO:0000269|PubMed:30122540, ECO:0000269|PubMed:30122541}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:A8IRK7}. Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:30122540, ECO:0000269|PubMed:30122541}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=T1 {ECO:0000303|PubMed:30122540};
CC IsoId=Q8TBY9-1; Sequence=Displayed;
CC Name=2; Synonyms=T2 {ECO:0000303|PubMed:30122540};
CC IsoId=Q8TBY9-2; Sequence=VSP_027167, VSP_027168;
CC Name=3;
CC IsoId=Q8TBY9-3; Sequence=VSP_027165, VSP_027166;
CC -!- TISSUE SPECIFICITY: Isoform 1 is highly expressed in testis and, at
CC lower levels, in lung. Very low levels are detected in kidney and brain
CC (PubMed:30122540). In testis, expressed in spermatozoa (at protein
CC level) (PubMed:30122540, PubMed:30122541). Isoform 2 is not detected in
CC testis, lung, kidney, nor in brain (PubMed:30122540).
CC {ECO:0000269|PubMed:30122540, ECO:0000269|PubMed:30122541}.
CC -!- DISEASE: Spermatogenic failure 33 (SPGF33) [MIM:618152]: An autosomal
CC recessive infertility disorder caused by spermatogenesis defects that
CC result in multiple abnormalities of sperm flagellum, including short,
CC bent, curled, thick, or absent flagella. {ECO:0000269|PubMed:30122540,
CC ECO:0000269|PubMed:30122541}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
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DR EMBL; AC069503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028421; AAH28421.1; -; mRNA.
DR EMBL; BC036233; AAH36233.1; -; mRNA.
DR EMBL; AK097102; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL833930; CAD38786.1; -; mRNA.
DR CCDS; CCDS41853.1; -. [Q8TBY9-1]
DR CCDS; CCDS53840.1; -. [Q8TBY9-2]
DR RefSeq; NP_001171474.1; NM_001178003.1. [Q8TBY9-2]
DR RefSeq; NP_653269.3; NM_144668.5. [Q8TBY9-1]
DR AlphaFoldDB; Q8TBY9; -.
DR BioGRID; 126850; 4.
DR IntAct; Q8TBY9; 1.
DR STRING; 9606.ENSP00000288912; -.
DR iPTMnet; Q8TBY9; -.
DR PhosphoSitePlus; Q8TBY9; -.
DR BioMuta; WDR66; -.
DR DMDM; 313104048; -.
DR EPD; Q8TBY9; -.
DR MassIVE; Q8TBY9; -.
DR MaxQB; Q8TBY9; -.
DR PaxDb; Q8TBY9; -.
DR PeptideAtlas; Q8TBY9; -.
DR PRIDE; Q8TBY9; -.
DR ProteomicsDB; 74051; -. [Q8TBY9-1]
DR ProteomicsDB; 74052; -. [Q8TBY9-2]
DR ProteomicsDB; 74053; -. [Q8TBY9-3]
DR Antibodypedia; 31607; 101 antibodies from 19 providers.
DR DNASU; 144406; -.
DR Ensembl; ENST00000288912.9; ENSP00000288912.4; ENSG00000158023.10. [Q8TBY9-1]
DR Ensembl; ENST00000397454.2; ENSP00000380595.2; ENSG00000158023.10. [Q8TBY9-2]
DR GeneID; 144406; -.
DR KEGG; hsa:144406; -.
DR MANE-Select; ENST00000288912.9; ENSP00000288912.4; NM_144668.6; NP_653269.3.
DR UCSC; uc009zxk.4; human. [Q8TBY9-1]
DR CTD; 144406; -.
DR DisGeNET; 144406; -.
DR GeneCards; CFAP251; -.
DR HGNC; HGNC:28506; CFAP251.
DR HPA; ENSG00000158023; Tissue enhanced (fallopian tube, testis).
DR MalaCards; CFAP251; -.
DR MIM; 618146; gene.
DR MIM; 618152; phenotype.
DR neXtProt; NX_Q8TBY9; -.
DR OpenTargets; ENSG00000158023; -.
DR Orphanet; 276234; Non-syndromic male infertility due to sperm motility disorder.
DR PharmGKB; PA142670599; -.
DR VEuPathDB; HostDB:ENSG00000158023; -.
DR eggNOG; ENOG502QQ05; Eukaryota.
DR GeneTree; ENSGT00390000013370; -.
DR HOGENOM; CLU_007087_0_0_1; -.
DR InParanoid; Q8TBY9; -.
DR OMA; ISCCVVS; -.
DR OrthoDB; 169738at2759; -.
DR PhylomeDB; Q8TBY9; -.
DR TreeFam; TF328993; -.
DR PathwayCommons; Q8TBY9; -.
DR SignaLink; Q8TBY9; -.
DR BioGRID-ORCS; 144406; 10 hits in 1080 CRISPR screens.
DR GenomeRNAi; 144406; -.
DR Pharos; Q8TBY9; Tbio.
DR PRO; PR:Q8TBY9; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8TBY9; protein.
DR Bgee; ENSG00000158023; Expressed in right uterine tube and 111 other tissues.
DR Genevisible; Q8TBY9; HS.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; IDA:UniProtKB.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR GO; GO:0030317; P:flagellated sperm motility; IMP:UniProtKB.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 9.
DR SUPFAM; SSF47473; SSF47473; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cilium; Cytoplasm; Cytoskeleton;
KW Flagellum; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1149
FT /note="Cilia- and flagella-associated protein 251"
FT /id="PRO_0000296255"
FT REPEAT 335..377
FT /note="WD 1"
FT REPEAT 385..425
FT /note="WD 2"
FT REPEAT 436..475
FT /note="WD 3"
FT REPEAT 493..528
FT /note="WD 4"
FT REPEAT 531..591
FT /note="WD 5"
FT REPEAT 595..635
FT /note="WD 6"
FT REPEAT 641..678
FT /note="WD 7"
FT REPEAT 688..724
FT /note="WD 8"
FT REPEAT 731..774
FT /note="WD 9"
FT REPEAT 785..825
FT /note="WD 10"
FT REPEAT 831..877
FT /note="WD 11"
FT REPEAT 883..921
FT /note="WD 12"
FT REPEAT 959..999
FT /note="WD 13"
FT REPEAT 1019..1059
FT /note="WD 14"
FT REGION 1..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 297..370
FT /note="GHANIISCLCVSEDRRWIATADKGPDCLVIIWDSFTGIPVHTIFDSCPEGNG
FT IMAMAMTHDAKYLATISDAEVQ -> VCRDFLPTGGGVVFNVRVVFCFVSQGLTSFYHC
FT RIFPLSLELKASLSLETHGIVYCLSVSNQNQLTKQQLILIL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027165"
FT VAR_SEQ 371..1149
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027166"
FT VAR_SEQ 925..941
FT /note="VLEAAVSLGGEDLTPFY -> HPGSQAPILSPSDTSRS (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027167"
FT VAR_SEQ 942..1149
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027168"
FT VARIANT 61
FT /note="E -> G (in dbSNP:rs12824001)"
FT /id="VAR_034623"
FT VARIANT 66
FT /note="G -> E (in dbSNP:rs12824001)"
FT /id="VAR_060044"
FT VARIANT 111..1149
FT /note="Missing (in SPGF33; dbSNP:rs199671406)"
FT /evidence="ECO:0000269|PubMed:30122541"
FT /id="VAR_081181"
FT VARIANT 383
FT /note="T -> M (in dbSNP:rs34768683)"
FT /id="VAR_034624"
FT VARIANT 445
FT /note="L -> F (in dbSNP:rs11043265)"
FT /id="VAR_034625"
FT CONFLICT 62
FT /note="G -> GEEEEK (in Ref. 2; AAH28421/AAH36233)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="M -> I (in Ref. 3; AK097102)"
FT /evidence="ECO:0000305"
FT CONFLICT 650
FT /note="L -> F (in Ref. 2; AAH28421 and 4; CAD38786)"
FT /evidence="ECO:0000305"
FT CONFLICT 810
FT /note="F -> L (in Ref. 2; AAH36233)"
FT /evidence="ECO:0000305"
FT CONFLICT 870
FT /note="V -> L (in Ref. 2; AAH28421 and 4; CAD38786)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1149 AA; 129952 MW; CFC47771F6A71BB2 CRC64;
MSDAAEAPRE ATGENGETEM KEEEEPNPNY KEVEDPQQES KDDTIAWRES QEEERKTGEE
EGEEEGKEDK KIVMEETEEK AGEVQEKEAS GIQEETTVEP QEVTASMIRL ETQITDSQSI
TSGIFPKTQR GSKSKLSLQL EDAETDELLR DLSTQIEFLD LDQISPEEQQ ISSPERQPSG
ELEEKTDRMP QDELGQERRD LEPENREEGQ ERRVSDIQSK AGISRESLVS STTEDILFQK
DKSTPVYPLT MTWSFGWNSS LPVYYIREER QRVLLYVCAH TAIIYNVFRN NQYHLQGHAN
IISCLCVSED RRWIATADKG PDCLVIIWDS FTGIPVHTIF DSCPEGNGIM AMAMTHDAKY
LATISDAEVQ KVCIWKWTLA VETPACTLEL PTEYGVQNYV TFNPTNNKEL VSNSKTRAIY
YAWYEERDTL AHSAPLLTEK TFNKLVGKFS QSIFHLNLTQ ILSATMEGKL VVWDIHRPPS
SASTFLGFPY IKPCKLVHLQ KEGITVLTTI DSYIVTGDIK GNIKFYDHTL SIVNWYSHLK
LGAIRTLSFS KTPATPPTEK SNYPPDCTLK GDLFVLRNFI IGTSDAAVYH LTTDGTKLEK
LFVEPKDAIC AISCHPYQPL IAIGSICGMI KVWNYENKQY LFSRVFEKGL GVQSLTYNPE
GALLGAGFTE GTVYILDAMS LENESPEPFK YSRTSVTHIS FSHDSQYMAT ADRSFTVAVY
MLVVRNGQRV WEYLARLRSH RKSIRSLLFG VYLDSNEPRL LSLGTDRLLI EYDLLRSYKD
HLEVLDIHHT DQGCYPTCMV WYPPLTRELF LLICNSGYKV KLFNATTKMC RKTLLGPAYG
SPIEQTQVLP VRSMAELQKR YLVFINRDKV GLQILPVDGN PHKTSAIVCH PNGVAGMAVS
YDGCYAFTAG GHDRSVVQWK ITLSVLEAAV SLGGEDLTPF YGLLSGGREG KFYRELEDYF
YYSQLRSQGI DTMETRKVSE HICLSELPFV MRAIGFYPSE EKIDDIFNEI KFGEYVDTGK
LIDKINLPDF LKVYLNHKPP FGNTMSGIHK SFEVLGYTNS KGKKAIRRED FLRLLVTKGE
HMTEEEMLDC FASLFGLNPE GWKSEPATCS VKGSEICLEE ELPDEITAEI FATEILGLTI
SEDSGQDGQ
