ID   CF251_PONAB             Reviewed;        1155 AA.
AC   Q5RE88;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Cilia- and flagella-associated protein 251 {ECO:0000305};
DE   AltName: Full=WD repeat-containing protein 66 {ECO:0000250|UniProtKB:Q8TBY9};
GN   Name=CFAP251 {ECO:0000250|UniProtKB:Q8TBY9};
GN   Synonyms=WDR66 {ECO:0000250|UniProtKB:Q8TBY9};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in spermatozoa motility (By similarity). May also
CC       regulate cilium motility through its role in the assembly of the
CC       axonemal radial spokes (By similarity). {ECO:0000250|UniProtKB:A8IRK7,
CC       ECO:0000250|UniProtKB:Q24DE2, ECO:0000250|UniProtKB:Q8TBY9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:A8IRK7}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q8TBY9}.
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DR   EMBL; CR857646; CAH89919.1; -; mRNA.
DR   RefSeq; NP_001124901.1; NM_001131429.1.
DR   AlphaFoldDB; Q5RE88; -.
DR   STRING; 9601.ENSPPYP00000005763; -.
DR   GeneID; 100171768; -.
DR   KEGG; pon:100171768; -.
DR   CTD; 144406; -.
DR   eggNOG; ENOG502QQ05; Eukaryota.
DR   InParanoid; Q5RE88; -.
DR   OrthoDB; 169738at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR   GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 9.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1155
FT                   /note="Cilia- and flagella-associated protein 251"
FT                   /id="PRO_0000296256"
FT   REPEAT          341..383
FT                   /note="WD 1"
FT   REPEAT          391..431
FT                   /note="WD 2"
FT   REPEAT          442..481
FT                   /note="WD 3"
FT   REPEAT          499..534
FT                   /note="WD 4"
FT   REPEAT          537..597
FT                   /note="WD 5"
FT   REPEAT          601..641
FT                   /note="WD 6"
FT   REPEAT          647..684
FT                   /note="WD 7"
FT   REPEAT          694..730
FT                   /note="WD 8"
FT   REPEAT          737..780
FT                   /note="WD 9"
FT   REPEAT          791..831
FT                   /note="WD 10"
FT   REPEAT          837..883
FT                   /note="WD 11"
FT   REPEAT          889..927
FT                   /note="WD 12"
FT   REPEAT          965..1005
FT                   /note="WD 13"
FT   REPEAT          1025..1065
FT                   /note="WD 14"
FT   REGION          1..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          167..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..55
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..99
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..220
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1155 AA;  130765 MW;  75E2E20B9C4C2DE9 CRC64;
     MSDAEEAPRE ATRENGETEM KEEEEPNPNY KEVEDPQQES KDDTLAWRES QEEERKTGEE
     EGEEEEEKEE EGKKDKKIVM EETEEKAGES QEKEASGIQE ETTVEPQEVT ESMIRLETQI
     TDSQSVTSGI FPKTQRGSKS KLSLQLEDAE TDELLRDLST QLEFLDLDQI SPEEQQISSP
     ERQPSGELEE KTDQMPQDEL GQERRDLEPE NREEGQERTV SDIQSKAGIS RESLVSSTTE
     DILFQKDKSA PVYPLTMTWS FGWNSSLPVY YIREEKQRVL LYVCAHTAII YNVFRNNQYH
     LQGHANIISC LCVSEDRRWI ATADKGPDCL VIIWDSFTGI PVHTIFDSCP EGSGIRAMAM
     THDAKYLATI SDAEVQKVCI WKWTLAVETP ACTLELPTEY GVQNYVTFNP TNNKELVSNS
     KTWAIYYAWY EERDTLAHSA PLLTEKTFNK LVGKFSQSVF HLNLTQILSA TMEGKLVVWD
     IHRPPSSAST FLGFPYIKPC KLVHLQKEGI TVLTTTDSYI VTGDIKGNIK FYDHTLSIVN
     WYSHLKLGAI RTLSFSKTPA TPPTEKSNYP PDCTLKGDLF VLRNFIIGTS DAAVYHLTTD
     GTKLEKLFVE PKDAICAISC HPYQPLIAIG SICGMIKVWN YENKQYLFSR VFEKGLGVQS
     LTYNPEGALL GAGFTEGTVY ILDAMSLENE SPEPFKYSRT SVTHISFSHD SQYMATADRS
     FTVAVYMLVV RNGQRVWEYL ARLRSHRKSI RSLLFGVYLD SNEPRLLSLG TDRLLIGYDL
     LRSYKDCLEV LDIHHTDQGC YPTCMVWYPP LTRELFLLIC NSGYKVKLFN ATTKMCRKTL
     LGPAYGSPIE QTQVLPVRSM AELQKRYLVF INRDKVGLQI LPVDGNPHKT SAIVCHPNGV
     AGMAVSYDGH YAFTAGGHDR SVVQWKITLS VLEAAVSLGG EDLTPFYGLL SGGREGKFYR
     ELEDYFYYSQ LRSQGIDTME TRKVSEHICL SELPFVMRAI GFYPSEEKID DIFNEIKFGE
     YVDTGKLIDK INLPDFLKVY LNHKPPFGNT MSGIHKSFEV LGYTNSKGKK AIRREDFLRL
     LVTKGEHMTE EEMLDCFASL FGLNPEGWKS EPATSSVKGS EICLEEELPD EITAEIFATE
     ILGLTISEYS SQDGQ