ID   CF276_BOVIN             Reviewed;         170 AA.
AC   E1B9I5;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Cilia- and flagella-associated protein 276;
GN   Name=CFAP276 {ECO:0000312|VGNC:VGNC:54906}; Synonyms=C3H1orf194;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000312|Proteomes:UP000009136};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0007744|PDB:7RRO}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA   Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA   Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA   Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT   "De novo identification of mammalian ciliary motility proteins using cryo-
RT   EM.";
RL   Cell 184:5791-5806.e19(2021).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating (PubMed:34715025). May play an important role for
CC       the maintenance of myelin-axon integrity (By similarity). May affect
CC       intracellular Ca(2+) homeostasis (By similarity).
CC       {ECO:0000250|UniProtKB:Q5T5A4, ECO:0000250|UniProtKB:Q9DAD0,
CC       ECO:0000269|PubMed:34715025}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:34715025}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q5T5A4}. Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q5T5A4}.
CC   -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC       {ECO:0000269|PubMed:34715025}.
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DR   RefSeq; XP_002686201.1; XM_002686155.2.
DR   RefSeq; XP_869508.2; XM_864415.5.
DR   PDB; 7RRO; EM; 3.40 A; q/r/s=1-170.
DR   PDBsum; 7RRO; -.
DR   STRING; 9913.ENSBTAP00000033480; -.
DR   PaxDb; E1B9I5; -.
DR   Ensembl; ENSBTAT00000033568.4; ENSBTAP00000033480.3; ENSBTAG00000001135.5.
DR   GeneID; 613530; -.
DR   KEGG; bta:613530; -.
DR   CTD; 127003; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001135; -.
DR   VGNC; VGNC:54906; CFAP276.
DR   eggNOG; ENOG502S2J1; Eukaryota.
DR   GeneTree; ENSGT01030000234625; -.
DR   HOGENOM; CLU_133894_0_0_1; -.
DR   InParanoid; E1B9I5; -.
DR   OMA; ANIRQWI; -.
DR   OrthoDB; 1429280at2759; -.
DR   TreeFam; TF325898; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000001135; Expressed in semen and 44 other tissues.
DR   GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0015232; F:heme transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0097037; P:heme export; IBA:GO_Central.
DR   InterPro; IPR022179; DUF3695.
DR   Pfam; PF12494; DUF3695; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..170
FT                   /note="Cilia- and flagella-associated protein 276"
FT                   /id="PRO_0000456161"
SQ   SEQUENCE   170 AA;  19358 MW;  99EBC29F2EAE1C4B CRC64;
     MPLTRDPFQN PALDKDDSYL GKSRASKKLP YKNPTHLAQQ QEPWCRLSST PTITSMKRDG
     FFFYSEIPKD DLDFRLAALY NHHTGTFKNK SEILTHQETI QDTRRIKTQF PGEFLPAPQP
     PLITSRANIR HWINPKKESI HSIQGSIVSP HTAATNGGYS RKNDGGFFST