CF276_DANRE
ID CF276_DANRE Reviewed; 164 AA.
AC A8Y5T1;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Protein CFAP276 {ECO:0000250|UniProtKB:Q5T5A4};
DE AltName: Full=Cilia- and flagella-associated protein 276 {ECO:0000250|UniProtKB:Q5T5A4};
GN Name=cfap276 {ECO:0000250|UniProtKB:Q5T5A4}; ORFNames=si:ch211-163l21.7;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating (By similarity). May play an important role for
CC the maintenance of myelin-axon integrity (By similarity). May affect
CC intracellular Ca(2+) homeostasis (By similarity).
CC {ECO:0000250|UniProtKB:E1B9I5, ECO:0000250|UniProtKB:Q5T5A4,
CC ECO:0000250|UniProtKB:Q9DAD0}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:E1B9I5}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q5T5A4}. Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q5T5A4}.
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DR EMBL; AL929282; CAP19606.1; -; Genomic_DNA.
DR RefSeq; NP_001107082.1; NM_001113610.1.
DR AlphaFoldDB; A8Y5T1; -.
DR SMR; A8Y5T1; -.
DR STRING; 7955.ENSDARP00000048622; -.
DR PaxDb; A8Y5T1; -.
DR PeptideAtlas; A8Y5T1; -.
DR Ensembl; ENSDART00000132657; ENSDARP00000121222; ENSDARG00000034457.
DR GeneID; 567726; -.
DR KEGG; dre:567726; -.
DR ZFIN; ZDB-GENE-081105-176; si:ch211-163l21.7.
DR eggNOG; ENOG502S2J1; Eukaryota.
DR GeneTree; ENSGT01030000234625; -.
DR HOGENOM; CLU_133894_0_0_1; -.
DR InParanoid; A8Y5T1; -.
DR OMA; ANIRQWI; -.
DR OrthoDB; 1429280at2759; -.
DR PhylomeDB; A8Y5T1; -.
DR PRO; PR:A8Y5T1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000034457; Expressed in testis and 15 other tissues.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005856; C:cytoskeleton; ISS:UniProtKB.
DR InterPro; IPR022179; DUF3695.
DR Pfam; PF12494; DUF3695; 1.
PE 3: Inferred from homology;
KW Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..164
FT /note="Protein CFAP276"
FT /id="PRO_0000359595"
FT REGION 145..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 164 AA; 18801 MW; A7130C754C30AC02 CRC64;
MPQERDPFPF PRYENDFTLT GRKEIQKLSD DKPTHLAQND EPWRRLHNTT TEASSRRTVF
HYDTTTPKDS LDIHLKAAYD HHLGLFQNKS QTVMQMETVG ADNGTKKNKE LEDSVCDAEN
KGIKVWVDTQ KASLYSIKGS IESHHTASTN RGYSRKHDGG FYST