CF298_DROME
ID CF298_DROME Reviewed; 291 AA.
AC Q9VZH1; Q8T478;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 03-JUL-2003, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Cilia- and flagella-associated protein 298 {ECO:0000305};
GN ORFNames=CG18675;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SIMILARITY: Belongs to the CFAP298 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF47852.3; -; Genomic_DNA.
DR EMBL; AY089317; AAL90055.1; -; mRNA.
DR RefSeq; NP_652334.2; NM_144077.3.
DR AlphaFoldDB; Q9VZH1; -.
DR BioGRID; 72572; 2.
DR DIP; DIP-22376N; -.
DR IntAct; Q9VZH1; 10.
DR STRING; 7227.FBpp0073074; -.
DR PaxDb; Q9VZH1; -.
DR DNASU; 50169; -.
DR EnsemblMetazoa; FBtr0073218; FBpp0073074; FBgn0040696.
DR GeneID; 50169; -.
DR KEGG; dme:Dmel_CG18675; -.
DR UCSC; CG18675-RA; d. melanogaster.
DR FlyBase; FBgn0040696; CG18675.
DR VEuPathDB; VectorBase:FBgn0040696; -.
DR eggNOG; ENOG502QQ3Z; Eukaryota.
DR GeneTree; ENSGT00390000006278; -.
DR HOGENOM; CLU_064854_0_0_1; -.
DR InParanoid; Q9VZH1; -.
DR OMA; QKQMMMH; -.
DR OrthoDB; 1079968at2759; -.
DR PhylomeDB; Q9VZH1; -.
DR BioGRID-ORCS; 50169; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG18675; fly.
DR GenomeRNAi; 50169; -.
DR PRO; PR:Q9VZH1; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0040696; Expressed in testis and 20 other tissues.
DR Genevisible; Q9VZH1; DM.
DR GO; GO:0003352; P:regulation of cilium movement; IEA:InterPro.
DR InterPro; IPR021298; CFAP298.
DR PANTHER; PTHR13238; PTHR13238; 1.
DR Pfam; PF11069; CFAP298; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..291
FT /note="Cilia- and flagella-associated protein 298"
FT /id="PRO_0000079522"
SQ SEQUENCE 291 AA; 33117 MW; BB1E45A1616081F3 CRC64;
MVLLQVKRGD ELIFLYETSV KEKTDTVLRE LVALHNGQLK IQRVCMEIEE LAEHGTMVPP
EMIGLNEEQR EELKLKDVWA DKCIPSGGFT INKDPLLRRN GQQPTEAMQK VLAGAMNDAK
AMVDRRLAKS SKTLTPKIVE EALNLLRGGV TIVYPMQLPP HDSIRMEFTN TEDLTGTQAS
KEVIEPSKAQ FWFAGHQMLM GKLMSDYLGH NDKTKVVVKL NQIGEGPPGR EAVISDPLRR
QMMAEAYRRQ EELKKLEQDD DDEYLNSSWA DSGSLKRQAH GLENVRFRFR K
