CF298_MOUSE
ID CF298_MOUSE Reviewed; 290 AA.
AC Q8BL95; Q8VCL7;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Cilia- and flagella-associated protein 298 {ECO:0000305};
DE AltName: Full=Protein kurly homolog {ECO:0000305};
GN Name=Cfap298 {ECO:0000250|UniProtKB:P57076};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a role in motile cilium function, possibly by acting on
CC outer dynein arm assembly. Seems to be important for initiation rather
CC than maintenance of cilium motility. Required for correct positioning
CC of cilia at the apical cell surface, suggesting an additional role in
CC the planar cell polarity (PCP) pathway. May suppress canonical Wnt
CC signaling activity. {ECO:0000250|UniProtKB:Q6DRC3}.
CC -!- SUBUNIT: Interacts with ZMYND10. {ECO:0000250|UniProtKB:P57076}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5U3Z0}.
CC Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000250|UniProtKB:A0A1L8HCK2}. Note=Partially colocalized with
CC SASS6 in cytoplasmic puncta, suggesting a centrosomal localization.
CC {ECO:0000250|UniProtKB:Q5U3Z0}.
CC -!- SIMILARITY: Belongs to the CFAP298 family. {ECO:0000305}.
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DR EMBL; AK045905; BAC32526.1; -; mRNA.
DR EMBL; AC134560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466602; EDL03846.1; -; Genomic_DNA.
DR EMBL; BC019533; AAH19533.1; -; mRNA.
DR CCDS; CCDS28321.1; -.
DR RefSeq; NP_080778.2; NM_026502.2.
DR AlphaFoldDB; Q8BL95; -.
DR BioGRID; 212591; 1.
DR STRING; 10090.ENSMUSP00000023694; -.
DR iPTMnet; Q8BL95; -.
DR PhosphoSitePlus; Q8BL95; -.
DR REPRODUCTION-2DPAGE; IPI00281363; -.
DR EPD; Q8BL95; -.
DR MaxQB; Q8BL95; -.
DR PaxDb; Q8BL95; -.
DR PeptideAtlas; Q8BL95; -.
DR PRIDE; Q8BL95; -.
DR DNASU; 68001; -.
DR Ensembl; ENSMUST00000023694; ENSMUSP00000023694; ENSMUSG00000022972.
DR GeneID; 68001; -.
DR KEGG; mmu:68001; -.
DR UCSC; uc007zwt.2; mouse.
DR CTD; 56683; -.
DR MGI; MGI:1915251; Cfap298.
DR VEuPathDB; HostDB:ENSMUSG00000022972; -.
DR eggNOG; ENOG502QQ3Z; Eukaryota.
DR GeneTree; ENSGT00390000006278; -.
DR HOGENOM; CLU_064854_0_0_1; -.
DR InParanoid; Q8BL95; -.
DR OMA; QKQMMMH; -.
DR OrthoDB; 1079968at2759; -.
DR PhylomeDB; Q8BL95; -.
DR TreeFam; TF323482; -.
DR BioGRID-ORCS; 68001; 26 hits in 71 CRISPR screens.
DR ChiTaRS; Cfap298; mouse.
DR PRO; PR:Q8BL95; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8BL95; protein.
DR Bgee; ENSMUSG00000022972; Expressed in animal zygote and 252 other tissues.
DR ExpressionAtlas; Q8BL95; baseline and differential.
DR Genevisible; Q8BL95; MM.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0060271; P:cilium assembly; ISO:MGI.
DR GO; GO:0003352; P:regulation of cilium movement; ISO:MGI.
DR InterPro; IPR021298; CFAP298.
DR PANTHER; PTHR13238; PTHR13238; 1.
DR Pfam; PF11069; CFAP298; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..290
FT /note="Cilia- and flagella-associated protein 298"
FT /id="PRO_0000424911"
FT CONFLICT 59
FT /note="P -> H (in Ref. 4; AAH19533)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 290 AA; 33190 MW; FC6329D384D3CFE9 CRC64;
MVVLHVKRGD ESQFLLQAPG STELEELTAQ VARVYNGRLK VHRLCSEMEE LAEHGVFLPP
NMQGLTDEQI EELKLKDEWG EKCVPSGGSV FTKDEIGRRN GQAPNEKMKQ VLKKTVEEAK
AIVSKKQVEA GVFVTMEMVK DALDQLRGAV MIVYPMGLPP YDPIRMEFEN KEDLSGTQAA
LEVIQESEAQ LWWAAKELRR TKKLSDYVGK NEKTKIIVKI QQRGQGAPAR EPVISSEEHK
QLMLFYHRRQ EELKKLEEND DDSCLNSPWA DNTALKRHFH GVKDIKWRPR
