ID   CF298_RAT               Reviewed;         290 AA.
AC   Q5U3Z0;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Cilia- and flagella-associated protein 298 {ECO:0000305};
DE   AltName: Full=Protein kurly homolog {ECO:0000305};
GN   Name=Cfap298 {ECO:0000312|RGD:1306954};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=24094744; DOI=10.1016/j.ajhg.2013.08.015;
RA   Austin-Tse C., Halbritter J., Zariwala M.A., Gilberti R.M., Gee H.Y.,
RA   Hellman N., Pathak N., Liu Y., Panizzi J.R., Patel-King R.S.,
RA   Tritschler D., Bower R., O'Toole E., Porath J.D., Hurd T.W., Chaki M.,
RA   Diaz K.A., Kohl S., Lovric S., Hwang D.Y., Braun D.A., Schueler M.,
RA   Airik R., Otto E.A., Leigh M.W., Noone P.G., Carson J.L., Davis S.D.,
RA   Pittman J.E., Ferkol T.W., Atkinson J.J., Olivier K.N., Sagel S.D.,
RA   Dell S.D., Rosenfeld M., Milla C.E., Loges N.T., Omran H., Porter M.E.,
RA   King S.M., Knowles M.R., Drummond I.A., Hildebrandt F.;
RT   "Zebrafish ciliopathy screen plus human mutational analysis identifies
RT   C21orf59 and CCDC65 defects as causing primary ciliary dyskinesia.";
RL   Am. J. Hum. Genet. 93:672-686(2013).
CC   -!- FUNCTION: Plays a role in motile cilium function, possibly by acting on
CC       outer dynein arm assembly. Seems to be important for initiation rather
CC       than maintenance of cilium motility. Required for correct positioning
CC       of cilia at the apical cell surface, suggesting an additional role in
CC       the planar cell polarity (PCP) pathway. May suppress canonical Wnt
CC       signaling activity. {ECO:0000250|UniProtKB:Q6DRC3}.
CC   -!- SUBUNIT: Interacts with ZMYND10. {ECO:0000250|UniProtKB:P57076}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24094744}.
CC       Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:A0A1L8HCK2}. Note=Partially colocalized with
CC       SASS6 in cytoplasmic puncta, suggesting a centrosomal localization.
CC       {ECO:0000269|PubMed:24094744}.
CC   -!- TISSUE SPECIFICITY: Expressed in the trachea (at protein level).
CC       {ECO:0000269|PubMed:24094744}.
CC   -!- SIMILARITY: Belongs to the CFAP298 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AABR06067650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH473989; EDM10699.1; -; Genomic_DNA.
DR   EMBL; BC085340; AAH85340.1; -; mRNA.
DR   RefSeq; NP_001008289.1; NM_001008288.1.
DR   AlphaFoldDB; Q5U3Z0; -.
DR   STRING; 10116.ENSRNOP00000030489; -.
DR   iPTMnet; Q5U3Z0; -.
DR   PhosphoSitePlus; Q5U3Z0; -.
DR   PaxDb; Q5U3Z0; -.
DR   PRIDE; Q5U3Z0; -.
DR   GeneID; 288269; -.
DR   KEGG; rno:288269; -.
DR   UCSC; RGD:1306954; rat.
DR   CTD; 56683; -.
DR   RGD; 1306954; Cfap298.
DR   VEuPathDB; HostDB:ENSRNOG00000021399; -.
DR   eggNOG; ENOG502QQ3Z; Eukaryota.
DR   HOGENOM; CLU_064854_0_0_1; -.
DR   InParanoid; Q5U3Z0; -.
DR   OMA; QKQMMMH; -.
DR   OrthoDB; 1079968at2759; -.
DR   PhylomeDB; Q5U3Z0; -.
DR   TreeFam; TF323482; -.
DR   PRO; PR:Q5U3Z0; -.
DR   Proteomes; UP000002494; Chromosome 11.
DR   Proteomes; UP000234681; Chromosome 11.
DR   Bgee; ENSRNOG00000021399; Expressed in ovary and 20 other tissues.
DR   Genevisible; Q5U3Z0; RN.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISO:RGD.
DR   GO; GO:0003352; P:regulation of cilium movement; ISO:RGD.
DR   InterPro; IPR021298; CFAP298.
DR   PANTHER; PTHR13238; PTHR13238; 1.
DR   Pfam; PF11069; CFAP298; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..290
FT                   /note="Cilia- and flagella-associated protein 298"
FT                   /id="PRO_0000424912"
SQ   SEQUENCE   290 AA;  33243 MW;  DAA9B88C40867687 CRC64;
     MVVLHVKRGD ESQFLLQAPG STELEELTAQ VTRVYNGRLK VHRLCTEIEE LAEHGVFLPP
     NMQGLTDEQI EELKLKDEWG EKCVPSGGSV FTKDDIGRRN GHAPNEKMKQ VLKKTVEEAK
     AMVSKKQVEA GVFVTMEMVK DALDQLRGAV MIVYPMGLPP YDPIRMEFEN KEDLSGTQAA
     LEVIQESEAQ LWWAAKELRR TKKLSDYVGK NEKTKIIVKI QQRGQGAPAR EPLISSEEHK
     QLMLFYHRRQ EELKKLEEND DDSCLNSPWA DNTALKRHFH GVKDIKWRPR