ID   CF299_DANRE             Reviewed;         239 AA.
AC   A2AVJ0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Cilia- and flagella-associated protein 299 {ECO:0000305};
GN   Name=cfap299 {ECO:0000250|UniProtKB:Q6V702}; ORFNames=si:ch211-57h10.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: May be involved in spermatogenesis.
CC       {ECO:0000250|UniProtKB:Q810M1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q810M1}. Nucleus
CC       {ECO:0000250|UniProtKB:Q810M1}. Note=Mainly cytoplasmic.
CC       {ECO:0000250|UniProtKB:Q810M1}.
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DR   EMBL; BX323826; CAM14262.1; -; Genomic_DNA.
DR   EMBL; AL929533; CAM14262.1; JOINED; Genomic_DNA.
DR   EMBL; AL929533; CAM15191.1; -; Genomic_DNA.
DR   EMBL; BX323826; CAM15191.1; JOINED; Genomic_DNA.
DR   RefSeq; NP_001108596.1; NM_001115124.1.
DR   AlphaFoldDB; A2AVJ0; -.
DR   STRING; 7955.ENSDARP00000115560; -.
DR   PaxDb; A2AVJ0; -.
DR   PeptideAtlas; A2AVJ0; -.
DR   Ensembl; ENSDART00000097872; ENSDARP00000088644; ENSDARG00000088753.
DR   GeneID; 558475; -.
DR   KEGG; dre:558475; -.
DR   CTD; 255119; -.
DR   ZFIN; ZDB-GENE-060526-173; cfap299.
DR   eggNOG; ENOG502QSP8; Eukaryota.
DR   GeneTree; ENSGT00390000016547; -.
DR   HOGENOM; CLU_070912_0_0_1; -.
DR   InParanoid; A2AVJ0; -.
DR   OMA; NYQEYLH; -.
DR   OrthoDB; 1202447at2759; -.
DR   PhylomeDB; A2AVJ0; -.
DR   TreeFam; TF323286; -.
DR   PRO; PR:A2AVJ0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000088753; Expressed in testis and 9 other tissues.
DR   ExpressionAtlas; A2AVJ0; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR027887; DUF4464.
DR   PANTHER; PTHR33588; PTHR33588; 1.
DR   Pfam; PF14713; DUF4464; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..239
FT                   /note="Cilia- and flagella-associated protein 299"
FT                   /id="PRO_0000301957"
SQ   SEQUENCE   239 AA;  27462 MW;  D4123E92B36A1C12 CRC64;
     MDNGKGVFSG EKMDEFRTYE DFLDSQIKPV DLFYLEDQEL ARQLVELGLK DSSLEREEFE
     TRKAAAEASR LASGSQQKKL ASTGKELKDN FLRALAEREE ANRSGEMNSI IFIRDQNARG
     QEISAYIDYS HRLKSEDFEP YFSGKKRLLP KTSDLSFYNW RTQKSKHNNS SNYEVITENP
     SGLLFKCKND RKILNVDPEK LPGDSSTRTP VQSDLYVHVV IYDHVIRKPT TRSCTPLSN