CF299_MOUSE
ID CF299_MOUSE Reviewed; 233 AA.
AC Q810M1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Cilia- and flagella-associated protein 299 {ECO:0000305};
GN Name=Cfap299 {ECO:0000303|PubMed:30820741};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND SUBCELLULAR LOCATION.
RX PubMed=30820741; DOI=10.1007/s11033-019-04651-8;
RA Li H., Dai Y., Luo Z., Nie D.;
RT "Cloning of a new testis-enriched gene C4orf22 and its role in cell cycle
RT and apoptosis in mouse spermatogenic cells.";
RL Mol. Biol. Rep. 46:2029-2038(2019).
CC -!- FUNCTION: May be involved in spermatogenesis.
CC {ECO:0000269|PubMed:30820741}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30820741}. Nucleus
CC {ECO:0000269|PubMed:30820741}. Note=Mainly cytoplasmic.
CC {ECO:0000269|PubMed:30820741}.
CC -!- TISSUE SPECIFICITY: Abundantly expressed in testis, specifically in
CC spermatogonia and primary spermatocytes but not in secondary
CC spermatocytes and spermatids. {ECO:0000269|PubMed:30820741}.
CC -!- DEVELOPMENTAL STAGE: First detected in testis in two week old mice;
CC expression continuously increases in testis from 2 to 8 weeks after
CC birth and remains at a constant level in 6-month-old testis.
CC {ECO:0000269|PubMed:30820741}.
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DR EMBL; BC049770; AAH49770.1; -; mRNA.
DR CCDS; CCDS19456.1; -.
DR RefSeq; NP_001019785.1; NM_001024614.1.
DR AlphaFoldDB; Q810M1; -.
DR STRING; 10090.ENSMUSP00000079208; -.
DR PhosphoSitePlus; Q810M1; -.
DR MaxQB; Q810M1; -.
DR PaxDb; Q810M1; -.
DR PRIDE; Q810M1; -.
DR Antibodypedia; 51658; 108 antibodies from 16 providers.
DR DNASU; 75784; -.
DR Ensembl; ENSMUST00000080333; ENSMUSP00000079208; ENSMUSG00000057816.
DR GeneID; 75784; -.
DR KEGG; mmu:75784; -.
DR UCSC; uc008yge.1; mouse.
DR CTD; 255119; -.
DR MGI; MGI:1916571; Cfap299.
DR VEuPathDB; HostDB:ENSMUSG00000057816; -.
DR eggNOG; ENOG502QSP8; Eukaryota.
DR GeneTree; ENSGT00390000016547; -.
DR HOGENOM; CLU_070912_0_0_1; -.
DR InParanoid; Q810M1; -.
DR OMA; NYQEYLH; -.
DR OrthoDB; 1202447at2759; -.
DR PhylomeDB; Q810M1; -.
DR TreeFam; TF323286; -.
DR BioGRID-ORCS; 75784; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q810M1; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q810M1; protein.
DR Bgee; ENSMUSG00000057816; Expressed in seminiferous tubule of testis and 39 other tissues.
DR ExpressionAtlas; Q810M1; baseline and differential.
DR Genevisible; Q810M1; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR027887; DUF4464.
DR PANTHER; PTHR33588; PTHR33588; 1.
DR Pfam; PF14713; DUF4464; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..233
FT /note="Cilia- and flagella-associated protein 299"
FT /id="PRO_0000301956"
SQ SEQUENCE 233 AA; 26938 MW; 49D5F8D1F112D506 CRC64;
MDQDEGLTAV DNIVTQFNTY EDFLDSQITT VDLYYLEDES LARQLVELGY RGTGEIVKRE
DFEARKAAIN IARQAERTQK KTLTSAGKEL HDDFLKALAM REEDNRAGKL STVIFIRDRN
PHGQEVSGYI DYAHRLKSED FEVYFNGKRR LLPRTTDMSF YNWDSHIAVC NSSPNYQVIA
DNPEGLLFKY KRDRKILNVD PKAHPGDNST RIPIQTDLYA HVVLFDHVSR RKT
