CF2_DROME
ID CF2_DROME Reviewed; 510 AA.
AC P20385; Q01522; Q0IGV4; Q24263; Q5U0W7; Q86BN0; Q86BN1; Q9VR41;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 3.
DT 03-AUG-2022, entry version 206.
DE RecName: Full=Chorion transcription factor Cf2;
GN Name=Cf2; ORFNames=CG11924;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, AND TISSUE
RP SPECIFICITY.
RC STRAIN=Oregon-R; TISSUE=Embryo, and Ovary;
RX PubMed=1411512; DOI=10.1126/science.1411512;
RA Hsu T., Gogos J.A., Kirsh S.A., Kafatos F.C.;
RT "Multiple zinc finger forms resulting from developmentally regulated
RT alternative splicing of a transcription factor gene.";
RL Science 257:1946-1950(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM II), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-455 (ISOFORM I).
RC STRAIN=Berkeley; TISSUE=Ovary, and Testis;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 248-510 (ISOFORM II), FUNCTION, AND
RP SUBCELLULAR LOCATION.
RC TISSUE=Embryo;
RX PubMed=2120114; DOI=10.1101/gad.4.7.1128;
RA Shea M.J., King D.L., Conboy M.J., Mariani B.D., Kafatos F.C.;
RT "Proteins that bind to Drosophila chorion cis-regulatory elements: a new
RT C2H2 zinc finger protein and a C2C2 steroid receptor-like component.";
RL Genes Dev. 4:1128-1140(1990).
CC -!- FUNCTION: Transcriptional regulator; binds to the promoter region of
CC Cp15. Also binds to its own promoter, thus having a probable
CC autoregulatory role. {ECO:0000269|PubMed:2120114}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:2120114}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=I; Synonyms=A;
CC IsoId=P20385-1; Sequence=Displayed;
CC Name=II; Synonyms=B, C, III;
CC IsoId=P20385-2; Sequence=VSP_006824;
CC -!- TISSUE SPECIFICITY: Isoform I is found in embryos, pupae and adult
CC somatic tissue; isoform II occurs in embryos, pupae, ovaries, testis
CC and to a lesser extent in adult somatic tissue.
CC {ECO:0000269|PubMed:1411512}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA28394.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAA28394.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAV37010.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; M97196; AAA28394.1; ALT_SEQ; Genomic_DNA.
DR EMBL; M97196; AAA28395.1; -; Genomic_DNA.
DR EMBL; M97196; AAA28396.1; -; Genomic_DNA.
DR EMBL; AE014134; AAF50966.2; -; Genomic_DNA.
DR EMBL; AE014134; AAO41152.1; -; Genomic_DNA.
DR EMBL; AE014134; AAO41153.1; -; Genomic_DNA.
DR EMBL; BT028816; ABI34197.1; -; mRNA.
DR EMBL; BT016125; AAV37010.1; ALT_SEQ; mRNA.
DR EMBL; X53380; CAA37460.1; -; mRNA.
DR PIR; A36901; A36901.
DR PIR; B36901; B36901.
DR PIR; C36901; C36901.
DR RefSeq; NP_523474.1; NM_078750.4. [P20385-1]
DR RefSeq; NP_787977.2; NM_175963.3. [P20385-2]
DR RefSeq; NP_787978.1; NM_175964.2. [P20385-2]
DR RefSeq; NP_787979.1; NM_175965.2. [P20385-2]
DR AlphaFoldDB; P20385; -.
DR SMR; P20385; -.
DR BioGRID; 59880; 9.
DR IntAct; P20385; 5.
DR STRING; 7227.FBpp0088592; -.
DR PaxDb; P20385; -.
DR PRIDE; P20385; -.
DR DNASU; 33692; -.
DR EnsemblMetazoa; FBtr0089647; FBpp0088590; FBgn0000286. [P20385-2]
DR EnsemblMetazoa; FBtr0089648; FBpp0088591; FBgn0000286. [P20385-2]
DR EnsemblMetazoa; FBtr0089649; FBpp0088592; FBgn0000286. [P20385-1]
DR EnsemblMetazoa; FBtr0304887; FBpp0293426; FBgn0000286. [P20385-2]
DR GeneID; 33692; -.
DR KEGG; dme:Dmel_CG11924; -.
DR UCSC; CG11924-RC; d. melanogaster.
DR CTD; 33692; -.
DR FlyBase; FBgn0000286; Cf2.
DR VEuPathDB; VectorBase:FBgn0000286; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000166773; -.
DR InParanoid; P20385; -.
DR SignaLink; P20385; -.
DR BioGRID-ORCS; 33692; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Cf2; fly.
DR GenomeRNAi; 33692; -.
DR PRO; PR:P20385; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0000286; Expressed in mouthpart and 28 other tissues.
DR ExpressionAtlas; P20385; baseline and differential.
DR Genevisible; P20385; DM.
DR GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0007527; P:adult somatic muscle development; IMP:FlyBase.
DR GO; GO:0046843; P:dorsal appendage formation; IMP:FlyBase.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:FlyBase.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IDA:FlyBase.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..510
FT /note="Chorion transcription factor Cf2"
FT /id="PRO_0000046914"
FT ZN_FING 74..97
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 125..148
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 366..388
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 401..423
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 429..451
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 457..479
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 485..508
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..32
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 430..457
FT /note="Missing (in isoform II)"
FT /evidence="ECO:0000303|PubMed:2120114, ECO:0000303|Ref.4"
FT /id="VSP_006824"
FT CONFLICT 254
FT /note="L -> S (in Ref. 1; AAA28394/AAA28395/AAA28396 and 5;
FT CAA37460)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 510 AA; 56750 MW; 4C692B85157DE0AB CRC64;
MIKSTTNPQE QRLPRPEDQS PAPPPPPPSS ATTSTAAPAT PTHQVATVIA NMDTLKTAFL
PNLSMDPNVH VSPHYCPMCH QQFERPQHVA DHMQLCHGIT LNAQGAIATL DGGHPQAQQH
PKLSHPCFNC DEKFGNAVDL DEHHRLAHQT PAFLSRCLMC SIYGIHSATQ QPNEYKCTQC
GSICTTAMLA AGQQGFMEQQ EAAVTPDDQL PAMAPRDMRL TPEEQHHQQQ LQAEHHHQQQ
HQQQQQQQQQ QQELLEQQQR EMQEQAQQQQ VHHHQQDQDL AGDQVALKVP PLTVKLNKNA
NGGAIVSHPQ VIIKEEPLSL SDSGDVVNSV PVYAIQANPG VPAPASSGVL VGTQTVPADL
AHKIRHKCPD CPKTFKTPGT LAMHRKIHTG EADATPKERP YTCSYCGKSF TQSNTLKQHT
RIHTGEKPFR CGYCGRAFTV KDYLNKHLTT HTGEKPFHCG YCEKSFSVKD YLTKHIRTHT
GEKPYTCPYC DKRFTQRSAL TVHTTKLHPL
