ID   CF300_RAT               Reviewed;         267 AA.
AC   Q68FQ4;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Cilia- and flagella-associated protein 300 {ECO:0000305};
GN   Name=Cfap300 {ECO:0000312|RGD:1591894};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cilium- and flagellum-specific protein that plays a role in
CC       axonemal structure organization and motility. May play a role in outer
CC       and inner dynein arm assembly. {ECO:0000250|UniProtKB:A0CY51}.
CC   -!- SUBUNIT: Interacts with DNAAF2. {ECO:0000250|UniProtKB:Q9BRQ4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A0CY51}.
CC       Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A0CY51}.
CC   -!- SIMILARITY: Belongs to the CFAP300 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC079425; AAH79425.1; -; mRNA.
DR   RefSeq; NP_001034263.1; NM_001039174.1.
DR   AlphaFoldDB; Q68FQ4; -.
DR   STRING; 10116.ENSRNOP00000061520; -.
DR   PaxDb; Q68FQ4; -.
DR   GeneID; 654482; -.
DR   KEGG; rno:654482; -.
DR   UCSC; RGD:1591894; rat.
DR   CTD; 85016; -.
DR   RGD; 1591894; Cfap300.
DR   VEuPathDB; HostDB:ENSRNOG00000043410; -.
DR   eggNOG; ENOG502QUFH; Eukaryota.
DR   HOGENOM; CLU_068703_0_0_1; -.
DR   InParanoid; Q68FQ4; -.
DR   OMA; VVPCTQI; -.
DR   OrthoDB; 1089634at2759; -.
DR   PhylomeDB; Q68FQ4; -.
DR   TreeFam; TF329188; -.
DR   PRO; PR:Q68FQ4; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000043410; Expressed in testis and 18 other tissues.
DR   Genevisible; Q68FQ4; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR   InterPro; IPR029416; CFAP300.
DR   PANTHER; PTHR31078; PTHR31078; 1.
DR   Pfam; PF14926; DUF4498; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..267
FT                   /note="Cilia- and flagella-associated protein 300"
FT                   /id="PRO_0000274277"
SQ   SEQUENCE   267 AA;  31058 MW;  12236E25AE3A0C4D CRC64;
     MATGEPRDRG GYYFRFLPQR TFSSLSAREI TNRLRQWSML GRIQAQAFGF DQTFQPYQKD
     DFVTAFFKDP NVIPHLQLLA ESSGQWTTLG TEVKRIEAIN VPCTQLSMSF FQRLYDENIV
     RESGHIVKCL DSFCDPFLIS DELRKVLLME DSEKYEVFSP VEREEFLFCL FKHLCLGGSL
     CQYEDVLKPY LETAKLIYKD LVSVRKHPRT KEIQITSSVF KVKAYDSLGV CYPSPKEHEQ
     TFSYFVVDPI KRHVNVLYHC YGVGEMA