CFA20_CAEBR
ID CFA20_CAEBR Reviewed; 203 AA.
AC Q61JK7; A8X9J9;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Cilia- and flagella-associated protein 20;
GN ORFNames=CBG09753;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Cilium- and flagellum-specific protein that plays a role in
CC axonemal structure organization and motility.
CC {ECO:0000250|UniProtKB:Q9Y6A4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y6A4}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC centriole {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm, cytoskeleton,
CC cilium basal body {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm,
CC cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q6B857}.
CC Note=Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme.
CC {ECO:0000250|UniProtKB:Q6B857}.
CC -!- SIMILARITY: Belongs to the CFAP20 family. {ECO:0000305}.
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DR EMBL; HE601459; CAP29314.1; -; Genomic_DNA.
DR RefSeq; XP_002641468.1; XM_002641422.1.
DR AlphaFoldDB; Q61JK7; -.
DR SMR; Q61JK7; -.
DR STRING; 6238.CBG09753; -.
DR PRIDE; Q61JK7; -.
DR EnsemblMetazoa; CBG09753a.1; CBG09753a.1; WBGene00031282.
DR GeneID; 8583459; -.
DR KEGG; cbr:CBG_09753; -.
DR CTD; 8583459; -.
DR WormBase; CBG09753a; CBP08422; WBGene00031282; -.
DR eggNOG; KOG3213; Eukaryota.
DR HOGENOM; CLU_060610_1_1_1; -.
DR InParanoid; Q61JK7; -.
DR OMA; TTYISCP; -.
DR OrthoDB; 1213295at2759; -.
DR Proteomes; UP000008549; Chromosome III.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:2000147; P:positive regulation of cell motility; ISS:UniProtKB.
DR GO; GO:2000253; P:positive regulation of feeding behavior; ISS:UniProtKB.
DR GO; GO:0060296; P:regulation of cilium beat frequency involved in ciliary motility; ISS:UniProtKB.
DR InterPro; IPR040441; CFA20/CFAP20DC.
DR InterPro; IPR007714; CFA20_dom.
DR PANTHER; PTHR12458; PTHR12458; 1.
DR Pfam; PF05018; DUF667; 1.
PE 3: Inferred from homology;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Microtubule; Nucleus;
KW Reference proteome.
FT CHAIN 1..203
FT /note="Cilia- and flagella-associated protein 20"
FT /id="PRO_0000296405"
SQ SEQUENCE 203 AA; 23670 MW; F3B5E996C6B5B391 CRC64;
MFHNTFQSGL LSVLYSIGSK PLQIWDTQIK NGHVKRITDE EIQSLVLEIM GNNISTAFIS
CPVDPEKTLG IKLPFFVMVV KNMNKYFSFE VQIIDDKKIK RRFRASNYQS ATRVKPFICT
MPMRMDEGWN QIQFNLSDFV KRAYGTNYVE TLRIQIHANC RIRRVYFADR LYTEDELPAE
FKLYLPIRGQ LSTQSPAFAM TSE