ID   CFA20_CHICK             Reviewed;         193 AA.
AC   Q5ZHP3;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Cilia- and flagella-associated protein 20;
GN   Name=CFAP20; ORFNames=RCJMB04_34o2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Cilium- and flagellum-specific protein that plays a role in
CC       axonemal structure organization and motility (By similarity). Involved
CC       in the regulation of the size and morphology of cilia. Required for
CC       axonemal microtubules polyglutamylation (By similarity).
CC       {ECO:0000250|UniProtKB:Q6B857, ECO:0000250|UniProtKB:Q9Y6A4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y6A4}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriole {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm, cytoskeleton,
CC       cilium basal body {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm,
CC       cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q6B857}.
CC       Note=Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme.
CC       {ECO:0000250|UniProtKB:Q6B857}.
CC   -!- SIMILARITY: Belongs to the CFAP20 family. {ECO:0000305}.
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DR   EMBL; AJ721091; CAG32750.1; -; mRNA.
DR   RefSeq; NP_001005833.1; NM_001005833.1.
DR   AlphaFoldDB; Q5ZHP3; -.
DR   SMR; Q5ZHP3; -.
DR   STRING; 9031.ENSGALP00000001318; -.
DR   PaxDb; Q5ZHP3; -.
DR   Ensembl; ENSGALT00000063870; ENSGALP00000043922; ENSGALG00000032634.
DR   Ensembl; ENSGALT00000079070; ENSGALP00000057041; ENSGALG00000032634.
DR   GeneID; 415627; -.
DR   KEGG; gga:415627; -.
DR   CTD; 29105; -.
DR   VEuPathDB; HostDB:geneid_415627; -.
DR   eggNOG; KOG3213; Eukaryota.
DR   GeneTree; ENSGT00390000004554; -.
DR   HOGENOM; CLU_060610_1_1_1; -.
DR   InParanoid; Q5ZHP3; -.
DR   OMA; TTYISCP; -.
DR   OrthoDB; 1213295at2759; -.
DR   PhylomeDB; Q5ZHP3; -.
DR   TreeFam; TF313405; -.
DR   PRO; PR:Q5ZHP3; -.
DR   Proteomes; UP000000539; Chromosome 11.
DR   Bgee; ENSGALG00000032634; Expressed in ovary and 13 other tissues.
DR   ExpressionAtlas; Q5ZHP3; baseline and differential.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:2000147; P:positive regulation of cell motility; ISS:UniProtKB.
DR   GO; GO:2000253; P:positive regulation of feeding behavior; ISS:UniProtKB.
DR   GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR   GO; GO:0060296; P:regulation of cilium beat frequency involved in ciliary motility; ISS:UniProtKB.
DR   InterPro; IPR040441; CFA20/CFAP20DC.
DR   InterPro; IPR007714; CFA20_dom.
DR   PANTHER; PTHR12458; PTHR12458; 1.
DR   Pfam; PF05018; DUF667; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Microtubule; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..193
FT                   /note="Cilia- and flagella-associated protein 20"
FT                   /id="PRO_0000296401"
SQ   SEQUENCE   193 AA;  22734 MW;  707CDB0D321EDAC2 CRC64;
     MFKNTFQSGF LSVLYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE GTNVSTTYIT
     CPADPKKTLG IKLPFLVMII KNLKKYFTFE VQVLDDKNVR RRFRASNYQS TTRVKPFICT
     MPMRLDDGWN QIQFNLSDFT RRAYGTNYIE TLRVQIHANC RIRRVYFSDR LYSEDELPAE
     FKLYLPVQNK AKQ