ID   CFA20_PARTE             Reviewed;         191 AA.
AC   A0CDD4;
DT   01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Cilia- and flagella-associated protein 20;
DE            Short=Bug22p;
GN   Name=CFAP20; Synonyms=Bug22, Bug22a, Bug22b, Bug22c, Bug22d;
GN   ORFNames=GSPATT00007012001, GSPATT00012810001, GSPATT00013199001,
GN   GSPATT00016658001;
OS   Paramecium tetraurelia.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX   NCBI_TaxID=5888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Stock d4-2;
RX   PubMed=17086204; DOI=10.1038/nature05230;
RA   Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA   Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA   Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA   Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA   Le Mouel A., Lepere G., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA   Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA   Weissenbach J., Scarpelli C., Schaechter V., Sperling L., Meyer E.,
RA   Cohen J., Wincker P.;
RT   "Global trends of whole-genome duplications revealed by the ciliate
RT   Paramecium tetraurelia.";
RL   Nature 444:171-178(2006).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=20118210; DOI=10.1128/ec.00368-09;
RA   Laligne C., Klotz C., de Loubresse N.G., Lemullois M., Hori M.,
RA   Laurent F.X., Papon J.F., Louis B., Cohen J., Koll F.;
RT   "Bug22p, a conserved centrosomal/ciliary protein also present in higher
RT   plants, is required for an effective ciliary stroke in Paramecium.";
RL   Eukaryot. Cell 9:645-655(2010).
CC   -!- FUNCTION: Cilium- and flagellum-specific protein required for axonemal
CC       structure organization and motility. May also play a role in cortical
CC       organization of basal body. {ECO:0000269|PubMed:20118210}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000269|PubMed:20118210}. Cell projection, cilium
CC       {ECO:0000269|PubMed:20118210}. Note=Localizes preferentially in the
CC       terminal plate of the basal body and the transition zone of the cilium
CC       as well as in the vicinity of the outer doublets of axoneme and between
CC       the axoneme and the cell membrane.
CC   -!- SIMILARITY: Belongs to the CFAP20 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CT868063; CAK68801.1; -; Genomic_DNA.
DR   EMBL; CT868263; CAK77302.1; -; Genomic_DNA.
DR   EMBL; CT868285; CAK77734.1; -; Genomic_DNA.
DR   EMBL; CT868418; CAK81845.1; -; Genomic_DNA.
DR   RefSeq; XP_001436198.1; XM_001436161.1.
DR   RefSeq; XP_001444699.1; XM_001444662.1.
DR   RefSeq; XP_001445131.1; XM_001445094.1.
DR   RefSeq; XP_001449242.1; XM_001449205.1.
DR   AlphaFoldDB; A0CDD4; -.
DR   SMR; A0CDD4; -.
DR   STRING; 5888.CAK68801; -.
DR   EnsemblProtists; CAK68801; CAK68801; GSPATT00007012001.
DR   EnsemblProtists; CAK77302; CAK77302; GSPATT00012810001.
DR   EnsemblProtists; CAK77734; CAK77734; GSPATT00013199001.
DR   EnsemblProtists; CAK81845; CAK81845; GSPATT00016658001.
DR   GeneID; 5021983; -.
DR   GeneID; 5030483; -.
DR   GeneID; 5030916; -.
DR   GeneID; 5035027; -.
DR   KEGG; ptm:GSPATT00007012001; -.
DR   KEGG; ptm:GSPATT00012810001; -.
DR   KEGG; ptm:GSPATT00013199001; -.
DR   KEGG; ptm:GSPATT00016658001; -.
DR   eggNOG; KOG3213; Eukaryota.
DR   HOGENOM; CLU_060610_1_1_1; -.
DR   InParanoid; A0CDD4; -.
DR   OMA; TTYISCP; -.
DR   Proteomes; UP000000600; Partially assembled WGS sequence.
DR   GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB.
DR   GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR   GO; GO:2000147; P:positive regulation of cell motility; IMP:UniProtKB.
DR   GO; GO:0060296; P:regulation of cilium beat frequency involved in ciliary motility; IMP:UniProtKB.
DR   InterPro; IPR040441; CFA20/CFAP20DC.
DR   InterPro; IPR007714; CFA20_dom.
DR   PANTHER; PTHR12458; PTHR12458; 1.
DR   Pfam; PF05018; DUF667; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Microtubule;
KW   Reference proteome.
FT   CHAIN           1..191
FT                   /note="Cilia- and flagella-associated protein 20"
FT                   /id="PRO_0000430500"
SQ   SEQUENCE   191 AA;  22486 MW;  580B6B9BE96BD546 CRC64;
     MFKNSFQSGF LSILYSIGSK PLQIWDKQIK NGHIKRITDQ DIQSSVLEIM GTNVSTNFIT
     APADPKETLG IKLPFLVMII KNLKKYFTFE VQVLDDKNVR RRFRASNYQS TTRVKPFICT
     MPMRLDEGWN QIQFNLSDFT RRAYGTNYIE TLRVQIHANC RIRRIYFSDR LYSEEELPPE
     FKLFLPIQKQ G