ID   CFA20_RAT               Reviewed;         164 AA.
AC   Q499T7;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Cilia- and flagella-associated protein 20;
DE   AltName: Full=Gene trap locus 3 protein homolog;
GN   Name=Cfap20; Synonyms=Gtl3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cilium- and flagellum-specific protein that plays a role in
CC       axonemal structure organization and motility (By similarity). Involved
CC       in the regulation of the size and morphology of cilia. Required for
CC       axonemal microtubules polyglutamylation (By similarity).
CC       {ECO:0000250|UniProtKB:Q6B857, ECO:0000250|UniProtKB:Q9Y6A4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y6A4}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriole {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm, cytoskeleton,
CC       cilium basal body {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm,
CC       cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q6B857}.
CC       Note=Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme.
CC       {ECO:0000250|UniProtKB:Q6B857}.
CC   -!- SIMILARITY: Belongs to the CFAP20 family. {ECO:0000305}.
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DR   EMBL; BC099768; AAH99768.1; -; mRNA.
DR   RefSeq; NP_001033067.1; NM_001037978.1.
DR   AlphaFoldDB; Q499T7; -.
DR   SMR; Q499T7; -.
DR   STRING; 10116.ENSRNOP00000058109; -.
DR   PaxDb; Q499T7; -.
DR   PRIDE; Q499T7; -.
DR   GeneID; 307642; -.
DR   KEGG; rno:307642; -.
DR   UCSC; RGD:1308493; rat.
DR   CTD; 29105; -.
DR   RGD; 1308493; Cfap20.
DR   eggNOG; KOG3213; Eukaryota.
DR   HOGENOM; CLU_060610_1_1_1; -.
DR   InParanoid; Q499T7; -.
DR   PRO; PR:Q499T7; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; Q499T7; RN.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:2000147; P:positive regulation of cell motility; ISS:UniProtKB.
DR   GO; GO:2000253; P:positive regulation of feeding behavior; ISS:UniProtKB.
DR   GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR   GO; GO:0060296; P:regulation of cilium beat frequency involved in ciliary motility; ISS:UniProtKB.
DR   InterPro; IPR040441; CFA20/CFAP20DC.
DR   InterPro; IPR007714; CFA20_dom.
DR   PANTHER; PTHR12458; PTHR12458; 1.
DR   Pfam; PF05018; DUF667; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Microtubule; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..164
FT                   /note="Cilia- and flagella-associated protein 20"
FT                   /id="PRO_0000296400"
SQ   SEQUENCE   164 AA;  19132 MW;  7CD9D2DD3998F67F CRC64;
     MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE GTNVSTTYIT
     CPADPKKTLG IKLPFLVMII KNLKKYFTFE VQVLDDKNVR RRFRASNYQS TTRVKPFICT
     MPMRLDDGWN QIQFNLSDFT RRAYDPCKLS YPKGLLLRQT LLRG