ID   CFA20_XENLA             Reviewed;         193 AA.
AC   Q6GPY6;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Cilia- and flagella-associated protein 20;
GN   Name=cfap20;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cilium- and flagellum-specific protein that plays a role in
CC       axonemal structure organization and motility (By similarity). Involved
CC       in the regulation of the size and morphology of cilia. Required for
CC       axonemal microtubules polyglutamylation (By similarity).
CC       {ECO:0000250|UniProtKB:Q6B857, ECO:0000250|UniProtKB:Q9Y6A4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y6A4}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriole {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm, cytoskeleton,
CC       cilium basal body {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm,
CC       cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q6B857}.
CC       Note=Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme.
CC       {ECO:0000250|UniProtKB:Q6B857}.
CC   -!- SIMILARITY: Belongs to the CFAP20 family. {ECO:0000305}.
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DR   EMBL; BC072969; AAH72969.1; -; mRNA.
DR   RefSeq; NP_001085578.1; NM_001092109.1.
DR   RefSeq; XP_018079499.1; XM_018224010.1.
DR   RefSeq; XP_018121938.1; XM_018266449.1.
DR   AlphaFoldDB; Q6GPY6; -.
DR   SMR; Q6GPY6; -.
DR   DNASU; 444004; -.
DR   GeneID; 108695480; -.
DR   GeneID; 444004; -.
DR   KEGG; xla:108695480; -.
DR   CTD; 108695480; -.
DR   CTD; 444004; -.
DR   Xenbase; XB-GENE-6256268; cfap20.L.
DR   Xenbase; XB-GENE-17346209; cfap20.S.
DR   OMA; CAGGCWA; -.
DR   OrthoDB; 1213295at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 108695480; Expressed in testis and 19 other tissues.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:2000147; P:positive regulation of cell motility; ISS:UniProtKB.
DR   GO; GO:2000253; P:positive regulation of feeding behavior; ISS:UniProtKB.
DR   GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR   GO; GO:0060296; P:regulation of cilium beat frequency involved in ciliary motility; ISS:UniProtKB.
DR   InterPro; IPR040441; CFA20/CFAP20DC.
DR   InterPro; IPR007714; CFA20_dom.
DR   PANTHER; PTHR12458; PTHR12458; 1.
DR   Pfam; PF05018; DUF667; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Microtubule; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..193
FT                   /note="Cilia- and flagella-associated protein 20"
FT                   /id="PRO_0000296403"
SQ   SEQUENCE   193 AA;  22734 MW;  3A6EF27EEA15A91B CRC64;
     MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEVE GTNVSTTYIT
     CPADPKKTLG IKLPFLVMII KNLKKYFTFE VQVLDDKNVR RRFRASNYQS TTRVKPFICT
     MPMRLDDGWN QIQFNLSDFT RRAYGTNYIE TLRVQIHANC RIRRVYFSDR LYSEDELPAE
     FKLYLPVQNK AKQ