CFA20_XENTR
ID CFA20_XENTR Reviewed; 193 AA.
AC Q6GL74;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=Cilia- and flagella-associated protein 20;
GN Name=cfap20;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cilium- and flagellum-specific protein that plays a role in
CC axonemal structure organization and motility (By similarity). Involved
CC in the regulation of the size and morphology of cilia. Required for
CC axonemal microtubules polyglutamylation (By similarity).
CC {ECO:0000250|UniProtKB:Q6B857, ECO:0000250|UniProtKB:Q9Y6A4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y6A4}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC centriole {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm, cytoskeleton,
CC cilium basal body {ECO:0000250|UniProtKB:Q9Y6A4}. Cytoplasm,
CC cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q6B857}.
CC Note=Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme.
CC {ECO:0000250|UniProtKB:Q6B857}.
CC -!- SIMILARITY: Belongs to the CFAP20 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC074631; AAH74631.1; -; mRNA.
DR RefSeq; NP_001004835.1; NM_001004835.1.
DR AlphaFoldDB; Q6GL74; -.
DR SMR; Q6GL74; -.
DR DNASU; 448101; -.
DR GeneID; 448101; -.
DR KEGG; xtr:448101; -.
DR CTD; 29105; -.
DR Xenbase; XB-GENE-6455885; cfap20.
DR InParanoid; Q6GL74; -.
DR Proteomes; UP000008143; Chromosome 6.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:2000147; P:positive regulation of cell motility; ISS:UniProtKB.
DR GO; GO:2000253; P:positive regulation of feeding behavior; ISS:UniProtKB.
DR GO; GO:0018095; P:protein polyglutamylation; ISS:UniProtKB.
DR GO; GO:0060296; P:regulation of cilium beat frequency involved in ciliary motility; ISS:UniProtKB.
DR InterPro; IPR040441; CFA20/CFAP20DC.
DR InterPro; IPR007714; CFA20_dom.
DR PANTHER; PTHR12458; PTHR12458; 1.
DR Pfam; PF05018; DUF667; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Microtubule; Nucleus;
KW Reference proteome.
FT CHAIN 1..193
FT /note="Cilia- and flagella-associated protein 20"
FT /id="PRO_0000296404"
SQ SEQUENCE 193 AA; 22734 MW; 3A6EF27EEA15A91B CRC64;
MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEVE GTNVSTTYIT
CPADPKKTLG IKLPFLVMII KNLKKYFTFE VQVLDDKNVR RRFRASNYQS TTRVKPFICT
MPMRLDDGWN QIQFNLSDFT RRAYGTNYIE TLRVQIHANC RIRRVYFSDR LYSEDELPAE
FKLYLPVQNK AKQ