CFA36_CAEEL
ID CFA36_CAEEL Reviewed; 685 AA.
AC Q95Y36; A0A0K3ASD3;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Cilia- and flagella-associated protein 36 {ECO:0000250|UniProtKB:Q96G28};
DE AltName: Full=Coiled-coil domain-containing protein 104 {ECO:0000250|UniProtKB:Q96G28};
GN Name=cfap-36 {ECO:0000312|WormBase:Y108G3AL.3a};
GN Synonyms=ccdc-104 {ECO:0000303|PubMed:27930654,
GN ECO:0000312|WormBase:Y108G3AL.3a};
GN ORFNames=Y108G3AL.3 {ECO:0000312|WormBase:Y108G3AL.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=27930654; DOI=10.1371/journal.pgen.1006469;
RA Jensen V.L., Carter S., Sanders A.A., Li C., Kennedy J., Timbers T.A.,
RA Cai J., Scheidel N., Kennedy B.N., Morin R.D., Leroux M.R., Blacque O.E.;
RT "Whole-organism developmental expression profiling identifies rab-28 as a
RT novel ciliary GTPase associated with the BBSome and intraflagellar
RT transport.";
RL PLoS Genet. 12:E1006469-E1006469(2016).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000269|PubMed:27930654}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:27930654}. Note=Localizes to the base of the
CC cilium. {ECO:0000269|PubMed:27930654}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:Y108G3AL.3a};
CC IsoId=Q95Y36-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:Y108G3AL.3b};
CC IsoId=Q95Y36-2; Sequence=VSP_058798;
CC -!- TISSUE SPECIFICITY: Expressed in amphid and phasmid ciliated neurons.
CC {ECO:0000269|PubMed:27930654}.
CC -!- SIMILARITY: Belongs to the CFAP36 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284605; CCD74338.1; -; Genomic_DNA.
DR EMBL; BX284605; CTQ86916.1; -; Genomic_DNA.
DR RefSeq; NP_001300217.1; NM_001313288.1. [Q95Y36-2]
DR RefSeq; NP_503147.1; NM_070746.4. [Q95Y36-1]
DR AlphaFoldDB; Q95Y36; -.
DR SMR; Q95Y36; -.
DR STRING; 6239.Y108G3AL.3; -.
DR PaxDb; Q95Y36; -.
DR PeptideAtlas; Q95Y36; -.
DR EnsemblMetazoa; Y108G3AL.3a.1; Y108G3AL.3a.1; WBGene00022435. [Q95Y36-1]
DR EnsemblMetazoa; Y108G3AL.3b.1; Y108G3AL.3b.1; WBGene00022435. [Q95Y36-2]
DR GeneID; 190931; -.
DR KEGG; cel:CELE_Y108G3AL.3; -.
DR UCSC; Y108G3AL.3; c. elegans. [Q95Y36-1]
DR CTD; 190931; -.
DR WormBase; Y108G3AL.3a; CE29094; WBGene00022435; cfap-36. [Q95Y36-1]
DR WormBase; Y108G3AL.3b; CE50736; WBGene00022435; cfap-36. [Q95Y36-2]
DR eggNOG; KOG4511; Eukaryota.
DR GeneTree; ENSGT00390000012785; -.
DR HOGENOM; CLU_401829_0_0_1; -.
DR InParanoid; Q95Y36; -.
DR OMA; HEPRAKT; -.
DR OrthoDB; 1017146at2759; -.
DR PRO; PR:Q95Y36; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00022435; Expressed in anatomical system and 4 other tissues.
DR GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR GO; GO:0097546; C:ciliary base; IDA:UniProtKB.
DR Gene3D; 1.20.1520.10; -; 1.
DR InterPro; IPR023379; BART_dom.
DR InterPro; IPR042541; BART_sf.
DR InterPro; IPR038888; CFAP36.
DR PANTHER; PTHR21532; PTHR21532; 1.
DR Pfam; PF11527; ARL2_Bind_BART; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW Cytoskeleton; Reference proteome.
FT CHAIN 1..685
FT /note="Cilia- and flagella-associated protein 36"
FT /evidence="ECO:0000305"
FT /id="PRO_0000439158"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 197..242
FT /evidence="ECO:0000255"
FT COMPBIAS 287..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..127
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_058798"
SQ SEQUENCE 685 AA; 75511 MW; FA9A5E134912A8FF CRC64;
MLRRFSKKNK NPEGGSDDAS RKQKKLLSKF LEFITSSIWS IPIASFIESQ SVVFDRQQME
TDVYIMIHKE YSQLIDTLIE CFCEDVGTTP TELVAAIQLF NQKDVSQQYK VALEPLLAAQ
NFNVFVPMMM RKNIELQLQA LQMIEFMCGL IPSVLQLEDG ETLRNMKKLS PEETERYVLI
SVLRHSKDEY DSMQKGSEEL EMMAQNSRIQ REALEQEIRK EEILLQQALD EGARAQNQNQ
NQGTSSTQTD GVNAPLRSVA AMMAATFAID TATSTDDVTY KFLDQSTGTM TSSTGVSVGT
LTNTGVSSGT MTSGVDTGTD ADGTVGRPKS AKRVGSAVGK RSVSKGTPSE DAKKSSGSSS
PDEAEKSKRE RPGTSVKKAI GIVAANSEMS SNGTQMDVPV DEEGTKKRPG TTSKKSIATV
TASPEMSSKT TQMEPEQDGE GKKRPETSKG ANERKYSNAG LEDIVGPKSS PHEEKKSSHP
SSRKGSKATD ENAPATRPPS RKAAGGSHEP RAKTPNQKNK DERPTTRRSS VDKNAPKRND
SVPRERKSSV SHDESKPPKP IGPLRGNKYD GDVVLGRAES PGIDHGPRRK NLNDVNSHLV
DTNRLNSSDV RVRAQYLREQ RDKLLQMKNA ERIKQMTDIQ QNASLERPKT AARAREILDK
DKKEAVAIRK EISDKLKTQI LTLHH