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CFA36_CAEEL
ID   CFA36_CAEEL             Reviewed;         685 AA.
AC   Q95Y36; A0A0K3ASD3;
DT   15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Cilia- and flagella-associated protein 36 {ECO:0000250|UniProtKB:Q96G28};
DE   AltName: Full=Coiled-coil domain-containing protein 104 {ECO:0000250|UniProtKB:Q96G28};
GN   Name=cfap-36 {ECO:0000312|WormBase:Y108G3AL.3a};
GN   Synonyms=ccdc-104 {ECO:0000303|PubMed:27930654,
GN   ECO:0000312|WormBase:Y108G3AL.3a};
GN   ORFNames=Y108G3AL.3 {ECO:0000312|WormBase:Y108G3AL.3a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=27930654; DOI=10.1371/journal.pgen.1006469;
RA   Jensen V.L., Carter S., Sanders A.A., Li C., Kennedy J., Timbers T.A.,
RA   Cai J., Scheidel N., Kennedy B.N., Morin R.D., Leroux M.R., Blacque O.E.;
RT   "Whole-organism developmental expression profiling identifies rab-28 as a
RT   novel ciliary GTPase associated with the BBSome and intraflagellar
RT   transport.";
RL   PLoS Genet. 12:E1006469-E1006469(2016).
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000269|PubMed:27930654}. Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000269|PubMed:27930654}. Note=Localizes to the base of the
CC       cilium. {ECO:0000269|PubMed:27930654}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a {ECO:0000312|WormBase:Y108G3AL.3a};
CC         IsoId=Q95Y36-1; Sequence=Displayed;
CC       Name=b {ECO:0000312|WormBase:Y108G3AL.3b};
CC         IsoId=Q95Y36-2; Sequence=VSP_058798;
CC   -!- TISSUE SPECIFICITY: Expressed in amphid and phasmid ciliated neurons.
CC       {ECO:0000269|PubMed:27930654}.
CC   -!- SIMILARITY: Belongs to the CFAP36 family. {ECO:0000305}.
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DR   EMBL; BX284605; CCD74338.1; -; Genomic_DNA.
DR   EMBL; BX284605; CTQ86916.1; -; Genomic_DNA.
DR   RefSeq; NP_001300217.1; NM_001313288.1. [Q95Y36-2]
DR   RefSeq; NP_503147.1; NM_070746.4. [Q95Y36-1]
DR   AlphaFoldDB; Q95Y36; -.
DR   SMR; Q95Y36; -.
DR   STRING; 6239.Y108G3AL.3; -.
DR   PaxDb; Q95Y36; -.
DR   PeptideAtlas; Q95Y36; -.
DR   EnsemblMetazoa; Y108G3AL.3a.1; Y108G3AL.3a.1; WBGene00022435. [Q95Y36-1]
DR   EnsemblMetazoa; Y108G3AL.3b.1; Y108G3AL.3b.1; WBGene00022435. [Q95Y36-2]
DR   GeneID; 190931; -.
DR   KEGG; cel:CELE_Y108G3AL.3; -.
DR   UCSC; Y108G3AL.3; c. elegans. [Q95Y36-1]
DR   CTD; 190931; -.
DR   WormBase; Y108G3AL.3a; CE29094; WBGene00022435; cfap-36. [Q95Y36-1]
DR   WormBase; Y108G3AL.3b; CE50736; WBGene00022435; cfap-36. [Q95Y36-2]
DR   eggNOG; KOG4511; Eukaryota.
DR   GeneTree; ENSGT00390000012785; -.
DR   HOGENOM; CLU_401829_0_0_1; -.
DR   InParanoid; Q95Y36; -.
DR   OMA; HEPRAKT; -.
DR   OrthoDB; 1017146at2759; -.
DR   PRO; PR:Q95Y36; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00022435; Expressed in anatomical system and 4 other tissues.
DR   GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR   GO; GO:0097546; C:ciliary base; IDA:UniProtKB.
DR   Gene3D; 1.20.1520.10; -; 1.
DR   InterPro; IPR023379; BART_dom.
DR   InterPro; IPR042541; BART_sf.
DR   InterPro; IPR038888; CFAP36.
DR   PANTHER; PTHR21532; PTHR21532; 1.
DR   Pfam; PF11527; ARL2_Bind_BART; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Reference proteome.
FT   CHAIN           1..685
FT                   /note="Cilia- and flagella-associated protein 36"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000439158"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          197..242
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        287..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..375
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..434
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..451
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..486
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        504..554
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..127
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_058798"
SQ   SEQUENCE   685 AA;  75511 MW;  FA9A5E134912A8FF CRC64;
     MLRRFSKKNK NPEGGSDDAS RKQKKLLSKF LEFITSSIWS IPIASFIESQ SVVFDRQQME
     TDVYIMIHKE YSQLIDTLIE CFCEDVGTTP TELVAAIQLF NQKDVSQQYK VALEPLLAAQ
     NFNVFVPMMM RKNIELQLQA LQMIEFMCGL IPSVLQLEDG ETLRNMKKLS PEETERYVLI
     SVLRHSKDEY DSMQKGSEEL EMMAQNSRIQ REALEQEIRK EEILLQQALD EGARAQNQNQ
     NQGTSSTQTD GVNAPLRSVA AMMAATFAID TATSTDDVTY KFLDQSTGTM TSSTGVSVGT
     LTNTGVSSGT MTSGVDTGTD ADGTVGRPKS AKRVGSAVGK RSVSKGTPSE DAKKSSGSSS
     PDEAEKSKRE RPGTSVKKAI GIVAANSEMS SNGTQMDVPV DEEGTKKRPG TTSKKSIATV
     TASPEMSSKT TQMEPEQDGE GKKRPETSKG ANERKYSNAG LEDIVGPKSS PHEEKKSSHP
     SSRKGSKATD ENAPATRPPS RKAAGGSHEP RAKTPNQKNK DERPTTRRSS VDKNAPKRND
     SVPRERKSSV SHDESKPPKP IGPLRGNKYD GDVVLGRAES PGIDHGPRRK NLNDVNSHLV
     DTNRLNSSDV RVRAQYLREQ RDKLLQMKNA ERIKQMTDIQ QNASLERPKT AARAREILDK
     DKKEAVAIRK EISDKLKTQI LTLHH
 
 
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