ID   CFA36_DANRE             Reviewed;         350 AA.
AC   Q1RM35; Q502G1; Q6NWC2;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Cilia- and flagella-associated protein 36 {ECO:0000305};
DE   AltName: Full=Coiled-coil domain-containing protein 104 {ECO:0000305};
GN   Name=cfap36 {ECO:0000305}; Synonyms=ccdc104 {ECO:0000305};
GN   ORFNames=zgc:136497;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Embryo, Heart, and Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96G28}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q96G28}. Cell projection, cilium, flagellum
CC       {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q1RM35-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q1RM35-2; Sequence=VSP_023339;
CC   -!- SIMILARITY: Belongs to the CFAP36 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH67646.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAH95710.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC067646; AAH67646.1; ALT_INIT; mRNA.
DR   EMBL; BC095710; AAH95710.1; ALT_INIT; mRNA.
DR   EMBL; BC115155; AAI15156.1; -; mRNA.
DR   RefSeq; NP_001035412.1; NM_001040322.1.
DR   AlphaFoldDB; Q1RM35; -.
DR   SMR; Q1RM35; -.
DR   STRING; 7955.ENSDARP00000093287; -.
DR   GeneID; 678564; -.
DR   KEGG; dre:678564; -.
DR   CTD; 112942; -.
DR   ZFIN; ZDB-GENE-060421-8162; cfap36.
DR   eggNOG; KOG4511; Eukaryota.
DR   InParanoid; Q1RM35; -.
DR   OrthoDB; 1373952at2759; -.
DR   PhylomeDB; Q1RM35; -.
DR   PRO; PR:Q1RM35; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR   GO; GO:0097546; C:ciliary base; IBA:GO_Central.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1520.10; -; 1.
DR   InterPro; IPR023379; BART_dom.
DR   InterPro; IPR042541; BART_sf.
DR   InterPro; IPR038888; CFAP36.
DR   PANTHER; PTHR21532; PTHR21532; 1.
DR   Pfam; PF11527; ARL2_Bind_BART; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW   Flagellum; Nucleus; Reference proteome.
FT   CHAIN           1..350
FT                   /note="Cilia- and flagella-associated protein 36"
FT                   /id="PRO_0000278642"
FT   REGION          171..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          142..167
FT                   /evidence="ECO:0000255"
FT   COILED          280..350
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        173..214
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..337
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         199..211
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_023339"
FT   CONFLICT        225
FT                   /note="Missing (in Ref. 1; AAI15156)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        231
FT                   /note="T -> A (in Ref. 1; AAH95710)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        251
FT                   /note="V -> A (in Ref. 1; AAI15156)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        315
FT                   /note="A -> T (in Ref. 1; AAI15156)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   350 AA;  39410 MW;  30087B16012C259C CRC64;
     MAEDSEWVPE SIAGFLGSPD WLIPLAEFME SRCSVFDDED ENKLTYTEIH QQYKQLVERL
     LENYMQDVGI SEQQFLEACS SFSSSASLQT VFQPVLATDD FQMFRSLMVQ KNMELQLQAL
     HVIKQRNGGL PECLTDGVDV MSELEQQEMK ILQEVLRRSK EEYDLQMGQC GLGSEDLAST
     SSSVSETPQN PEQRLSNGVS DPLTLTQPDS EMEESSTATQ RKMEESEPTA TTACKSKALP
     AVRAPLRGSV VAKQSSAERE RELERARDTH TDCRTLTDEV ALQQRSEYLK QQRDKLQALK
     RQTGKGLTDT AAAAAPEPKP ATQEISVEEK KKLQKRKHVA EKLKEEVIKK