CFA43_CHLRE
ID CFA43_CHLRE Reviewed; 1719 AA.
AC A8JAF2;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Cilia- and flagella-associated protein 43 {ECO:0000305};
GN Name=CFAP43 {ECO:0000305}; Synonyms=FAP43 {ECO:0000312|EMBL:EDO99120.1};
GN ORFNames=CHLREDRAFT_193355 {ECO:0000312|EMBL:EDO99120.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=15998802; DOI=10.1083/jcb.200504008;
RA Pazour G.J., Agrin N., Leszyk J., Witman G.B.;
RT "Proteomic analysis of a eukaryotic cilium.";
RL J. Cell Biol. 170:103-113(2005).
CC -!- FUNCTION: Flagellar protein involved in flagellum axoneme organization
CC and function. {ECO:0000250|UniProtKB:Q57WH1}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:15998802}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000250|UniProtKB:Q57WH1}.
CC -!- SIMILARITY: Belongs to the CFAP43 family. {ECO:0000305}.
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DR EMBL; DS496149; EDO99120.1; -; Genomic_DNA.
DR RefSeq; XP_001698838.1; XM_001698786.1.
DR AlphaFoldDB; A8JAF2; -.
DR STRING; 3055.EDO99120; -.
DR PaxDb; A8JAF2; -.
DR PRIDE; A8JAF2; -.
DR GeneID; 5724455; -.
DR eggNOG; ENOG502QQ39; Eukaryota.
DR HOGENOM; CLU_000937_1_0_1; -.
DR InParanoid; A8JAF2; -.
DR OrthoDB; 555110at2759; -.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR039692; CFAP43.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR14885:SF1; PTHR14885:SF1; 3.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50969; SSF50969; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW Repeat; WD repeat.
FT CHAIN 1..1719
FT /note="Cilia- and flagella-associated protein 43"
FT /id="PRO_0000431299"
FT REPEAT 122..165
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 174..214
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 226..263
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 308..345
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 413..452
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 513..552
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 697..736
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 749..788
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT REPEAT 1073..1114
FT /note="WD 9"
FT /evidence="ECO:0000255"
FT REGION 94..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1277..1296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1325..1372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1685..1719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1524..1609
FT /evidence="ECO:0000255"
FT COILED 1651..1679
FT /evidence="ECO:0000255"
SQ SEQUENCE 1719 AA; 177949 MW; 6F8CA8DB29693D1B CRC64;
MSIQTRSAVG YSGGQVTWTG PDECAWTCGN AVVLHTLGSK AQRVLKGTGF GISCFAVNKR
HGLLAIAEKG LKPMVTVYST KTLQPLAKLL PGDVREEGAG GGADKPSGSG AVSGKQQSSG
PSVVLGVTCL AFSNDGERLA VCGDEPDCSV IVYGWRKAEV LGRCRMPAAA SSASSTSPAS
SVSFHPLDAS VLATSGPGGA CAVWFLEPLW EKAVFRPLQL AAGALPAGAE VTCHAWGPGG
LYVGTSTGGL VLLDTATMAP LQLHAAAGGA AGEVAGGASG GASSPTPGAS SGGAAGGSVV
AVVPDAVTSG AAVTALTLNR DLVAVAGADG SVRVFVSVPA AAAAITPEPL ALSHEVWLGR
AGPARGVAVA SAECGGADHA TLLLGCPDGT MYRAPLAPKQ GGGPTHSVLV VDCHVGRLAG
VVPHPGGGAF LTTGSDGSVR VWSTTDGALL GRKQLSSAQT ALAAAAPGAS LAAVGSETGV
VRVLVLPPAS TAASAAASDA PLPALRVLFR QRLHSAPVDV LVFSPANDLL LSAGRDGIAW
LCSVDARGGR VRPLGCLSLP PGERVLSATW PRSDGGSGAA SGHAQAGPVS TTSAEGDEPS
CLLSLAGGGL MCLTASAELH SGNWRNPYPD MVLLVTIKLL RLEVAMLAVA AVPGDRYGDA
YGLGADKQLH KLVLPAEAAA WAGLRARPLR SAQHVPAHAR ASGGVAVAPG GHLLASGAAD
GTVALRNMSL ITLAAQQGGD GAGAGLHDIT AGGVVTVSFD ATGRYLASAG ADGALFVYEL
SKRAAVANRL ATLRSRIADL LAANEAAPEL ERLTRNDMIV DVGLVEELQR ETENRVAAVQ
AAVKKEHLRT ELLAERVRRM VWDSMAVKGA VISGLRAPPG QHERVLKQVT MLRRVELAEQ
AALGVIPYGL IDFDVYCNTR KALQVQLLKQ KMRDVQAGFN TDFNKVAAAK KADCDRIADL
NARLDDTLKD LRKLGAGPPA GLLDERFSLS AQQDTRDNIA ATVLMVREEE VGAERYVSPA
ERAKQEAARK ADEDAAKRSA KDNAGERALR QMMGGTLAAR GGGHDESNPF SLPKPAWLVA
LGVEPDAVNP KLITEEQNRE LKEWQAKEKS LQEERAKRIT VLEMELRTAK AAVEELTSEA
VERGLLARLG AAKEAHGRAA SELSERRAAL AELESRQAQL GADERLMDRN FKKEFAEADI
HLNRLLQLYR ARKPEQLASM PGGGAIGAAG GHQSGVEASS GSFSRVPGGA PGLHRQASLA
HSPSGAAAAG GEAAGAATAA GGAGSSGGAA PCGAAGNPST GPPANITPTY THALPLPHAA
VAATTLNPFP DAPPGASGHD RPGSSALHPS HSHASVHGNH AHHHLSAAAA AAGHSDPLHN
LSGLKPEGLD AALWDRFVAY RAERLAAEAG ARAAAGDLVL ARRDLPELES REAALGSEME
VLMGSITALR SERKVAAYDN EVQLRLLAGQ VEAMPPRPAS ADMSDARLLG RGVVESLNSV
VLGKGTKKVE LLTAMKDFKR GIYAAQWEAQ AADMRLDDLR AKIRDLQLLH VTRDMQTVLK
DGEDRSSALE AANLEALMKQ RERLHAKALE DKRRRLRKLA ADVSSRSAQN QEVAVHLVTL
GKVLEEQQRL QAGMQSANDQ ATRRMRSLVT HKKLKEIALA QQNELGELRQ QLEKLRLRTY
PTFIESGAVA GMPSPPRRLP PDIKLLAGSP SSSSVAGRT
