CFA44_CHLRE
ID CFA44_CHLRE Reviewed; 1764 AA.
AC A8J1V4;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Cilia- and flagella-associated protein 44 {ECO:0000305};
GN Name=CFAP44 {ECO:0000305}; Synonyms=FAP44;
GN ORFNames=CHLREDRAFT_149708 {ECO:0000312|EMBL:EDP01978.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=15998802; DOI=10.1083/jcb.200504008;
RA Pazour G.J., Agrin N., Leszyk J., Witman G.B.;
RT "Proteomic analysis of a eukaryotic cilium.";
RL J. Cell Biol. 170:103-113(2005).
CC -!- FUNCTION: Flagellar protein involved in sperm flagellum axoneme
CC organization and function. {ECO:0000250|UniProtKB:Q57WH1}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:15998802}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000250|UniProtKB:Q57WH1}.
CC -!- SIMILARITY: Belongs to the CFAP44 family. {ECO:0000305}.
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DR EMBL; DS496132; EDP01978.1; -; Genomic_DNA.
DR RefSeq; XP_001695270.1; XM_001695218.1.
DR AlphaFoldDB; A8J1V4; -.
DR STRING; 3055.EDP01978; -.
DR PaxDb; A8J1V4; -.
DR PRIDE; A8J1V4; -.
DR EnsemblPlants; PNW78215; PNW78215; CHLRE_09g386736v5.
DR GeneID; 5720832; -.
DR Gramene; PNW78215; PNW78215; CHLRE_09g386736v5.
DR eggNOG; KOG2106; Eukaryota.
DR HOGENOM; CLU_000928_0_0_1; -.
DR InParanoid; A8J1V4; -.
DR OrthoDB; 88812at2759; -.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IDA:GeneDB.
DR GO; GO:0060285; P:cilium-dependent cell motility; IMP:GeneDB.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW Repeat; WD repeat.
FT CHAIN 1..1764
FT /note="Cilia- and flagella-associated protein 44"
FT /id="PRO_0000431300"
FT REPEAT 115..157
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 160..199
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 208..248
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 255..294
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 361..400
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 454..493
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 495..534
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 649..692
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT REPEAT 707..752
FT /note="WD 9"
FT /evidence="ECO:0000255"
FT REPEAT 753..791
FT /note="WD 10"
FT /evidence="ECO:0000255"
FT REGION 570..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1426..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 821..850
FT /evidence="ECO:0000255"
FT COILED 1479..1517
FT /evidence="ECO:0000255"
FT COILED 1567..1674
FT /evidence="ECO:0000255"
FT COILED 1729..1758
FT /evidence="ECO:0000255"
FT COMPBIAS 583..625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..641
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1436..1464
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1764 AA; 186158 MW; 40B71FE283962F66 CRC64;
MPLMVLLLSQ RTGGVAQLLS VHGLDTHRRN NLVLLDEDTA ASCIAGQLVL LSLSTGARRY
LPGRDGGGVG AVAVHPSRTL LAVGEKARPG PASAGPAVYI YSYPGLEVVK VLRGGTERAY
SALAFDGERG DTLASVGHFP DFLLTLWDWR QEAIVLRAKA FSQDVYGVAF SPYFEGQLTT
SGQGHIRFWR MASTFTGLKL QGAIGKFGNV ELSDVAAFVE LPDGKVLSST ETGELLLWDG
GLIKVVLTRP GSRPCHDGPI EALLLDRPAG RVLSAGADGR VRMWDFGAVN DAEPREDSHS
LELSPLDEVV VAEGAALSAL LADSGGRRWV VADKAGNVYT VALPPAGPVG KGAVVTRVAS
HPAGAVAGLQ LSARTHTALV ASADGCLRAL DYVSGAVLAE AATPQRITAF TPLPAASPAC
PGGAMTAATG YRDGVVRLHA RCAEGLALVG VAKAHKGAVA ALAVSADGGR LVSAGEDGSV
FFFDLTAQPQ PGTGVPGMPA CGLLAPRAFI KLPSGSGTVT CGVWEAAEGG GVLLGTNRGT
ILSVPLPPPD LNTHHSYEWA AGTSAVSSYQ LVVPKPKRPK KKKGKNDGEE GDKEGGEQDE
GQGGEDKGGE QADGEGGSKE GGEEGRAAEE EEEEEADDEA DGGAGGPSST TGELISLTLA
PNEPGALLVT AGGVGHAARK AWRVRMGEPL AAPLLEGFAS APVTCLAHAG PEGRLALLGS
GDGLVRLQAL EEPFGSAAPG ALPLWEAPLH DMQSGRVSGL GLSHDGAYLV TAAADGALHL
LALALPPELA PPPTTQPGDE PLPGPAALPL RPPDVLAAAA YTLEEEKQQA ERDQQVREAE
EKKLSVRQRL GLIRAEFEAL LAENEAAPEA LRLPRADLEV DPGLRALMEA EALRREEVAR
LELAWESERQ RLGLAKLRRY FLDGLESERV VLHSLRGSST VTTFRVAKLS DETRAELAAM
RQAARAAAAA SAAAGGEGGA GGRDTDARGK GSDTGGGPGG DAAARARLAE ATAALEEGTA
SGKLNKADLR RLARKRREAE WAAFNGTRPD DTYDSPADLA AIEEARRTIG DFKLKSDPNY
VVPEEERLTP QRKRLAMLEL EEALHDIAAA FNAKFFALRD VKRKVLADVR VKLAALAELA
AAAGAATGGA DPDATAAAYL APFSGLPSGL LPEEEPAEAR EAVTDADLAA FAARKAEDER
KAAAAAAGGL GGFAGAAAGP KKPAAGGAAP AGGALAGGAA GSGSVAHGAG GPSAGGQQGL
TAAEEALAKM MAAVPQSELE KGLAAYNRRR VEHMRSKLSE EITAMLDAFD DAHSALKAEK
LGLEADVKAG QMRLLVGLQE LQLLREFDKR ESVLLAKRQA KLDDKQEIVD KIAECTDKLE
TKRLELEGLV ARRAAVVAEL DAVVPESDPF REALVRVFHR RIKRSKKKAG GGGGEDDYDS
EEDEEDEDMG DDEVDDDDDG GEEVCPPGCD QSVYERVCDL REKRLDEEDM IAEFTKTIEV
LRKEKEALAK KQRLVEQGLA AVNADMAEFQ KEKQGRLNQV EVIVALRMHQ IEYLLDGCLP
DDLSACLVFS ASQLRRLQAR VDELEEEKAG LRAAHKELRR QHAALLRDKA DKEARVAELE
ARAHDVQMLK FGQVIDLELL DRVSSSRGTE ELREDLKKQE LAYARELAEW DAKINARMDE
LVVLTRENTA CLNAVSELTA AQRRLESGLT ATRKGLFADP VQQRRAEVEE RDALVALVNA
QAAELDRLKG QLLALRRKDT SMYA
