CFA44_HUMAN
ID CFA44_HUMAN Reviewed; 1854 AA.
AC Q96MT7;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2018, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Cilia- and flagella-associated protein 44 {ECO:0000312|HGNC:HGNC:25631};
DE AltName: Full=WD repeat-containing protein 52 {ECO:0000312|HGNC:HGNC:25631};
GN Name=CFAP44 {ECO:0000312|HGNC:HGNC:25631};
GN Synonyms=WDR52 {ECO:0000312|HGNC:HGNC:25631};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1083, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [6]
RP INVOLVEMENT IN SPGF20.
RX PubMed=28552195; DOI=10.1016/j.ajhg.2017.04.012;
RA Tang S., Wang X., Li W., Yang X., Li Z., Liu W., Li C., Zhu Z., Wang L.,
RA Wang J., Zhang L., Sun X., Zhi E., Wang H., Li H., Jin L., Luo Y., Wang J.,
RA Yang S., Zhang F.;
RT "Biallelic mutations in CFAP43 and CFAP44 cause male infertility with
RT multiple morphological abnormalities of the sperm flagella.";
RL Am. J. Hum. Genet. 100:854-864(2017).
RN [7]
RP INVOLVEMENT IN SPGF20, TISSUE SPECIFICITY, AND VARIANTS SPGF20
RP 463-GLU--LEU-1854 DEL AND 1059-ARG--LEU-1854 DEL.
RX PubMed=29449551; DOI=10.1038/s41467-017-02792-7;
RA Coutton C., Vargas A.S., Amiri-Yekta A., Kherraf Z.E., Ben Mustapha S.F.,
RA Le Tanno P., Wambergue-Legrand C., Karaouzene T., Martinez G., Crouzy S.,
RA Daneshipour A., Hosseini S.H., Mitchell V., Halouani L., Marrakchi O.,
RA Makni M., Latrous H., Kharouf M., Deleuze J.F., Boland A., Hennebicq S.,
RA Satre V., Jouk P.S., Thierry-Mieg N., Conne B., Dacheux D., Landrein N.,
RA Schmitt A., Stouvenel L., Lores P., El Khouri E., Bottari S.P., Faure J.,
RA Wolf J.P., Pernet-Gallay K., Escoffier J., Gourabi H., Robinson D.R.,
RA Nef S., Dulioust E., Zouari R., Bonhivers M., Toure A., Arnoult C.,
RA Ray P.F.;
RT "Mutations in CFAP43 and CFAP44 cause male infertility and flagellum
RT defects in Trypanosoma and human.";
RL Nat. Commun. 9:686-686(2018).
CC -!- FUNCTION: Flagellar protein involved in sperm flagellum axoneme
CC organization and function. {ECO:0000250|UniProtKB:E9Q5M6}.
CC -!- INTERACTION:
CC Q96MT7; O95257: GADD45G; NbExp=3; IntAct=EBI-12551219, EBI-448202;
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:A8J1V4}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000250|UniProtKB:Q57WH1}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=2;
CC IsoId=Q96MT7-2; Sequence=Displayed;
CC Name=1;
CC IsoId=Q96MT7-1; Sequence=VSP_059893, VSP_059894;
CC -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:29449551}.
CC -!- DISEASE: Spermatogenic failure 20 (SPGF20) [MIM:617593]: An infertility
CC disorder caused by spermatogenesis defects and characterized by
CC abnormally shaped spermatozoa in the semen of affected individuals.
CC SPGF20 patients have spermatozoa with absent, short, coiled, bent,
CC and/or irregular-caliber flagella, which impair sperm motility.
CC {ECO:0000269|PubMed:28552195, ECO:0000269|PubMed:29449551}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- SIMILARITY: Belongs to the CFAP44 family. {ECO:0000305}.
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DR EMBL; AK056472; BAB71193.1; -; mRNA.
DR EMBL; AC023894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC026329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC026348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC112128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79641.1; -; Genomic_DNA.
DR EMBL; BC101582; AAI01583.1; -; mRNA.
DR EMBL; BC113553; AAI13554.1; -; mRNA.
DR CCDS; CCDS2972.1; -. [Q96MT7-1]
DR CCDS; CCDS54624.1; -. [Q96MT7-2]
DR RefSeq; NP_001157968.1; NM_001164496.1. [Q96MT7-2]
DR RefSeq; NP_060808.2; NM_018338.3. [Q96MT7-1]
DR AlphaFoldDB; Q96MT7; -.
DR BioGRID; 120894; 7.
DR IntAct; Q96MT7; 4.
DR STRING; 9606.ENSP00000377428; -.
DR iPTMnet; Q96MT7; -.
DR PhosphoSitePlus; Q96MT7; -.
DR BioMuta; CFAP44; -.
DR DMDM; 74760982; -.
DR EPD; Q96MT7; -.
DR jPOST; Q96MT7; -.
DR MassIVE; Q96MT7; -.
DR PaxDb; Q96MT7; -.
DR PeptideAtlas; Q96MT7; -.
DR PRIDE; Q96MT7; -.
DR ProteomicsDB; 77404; -. [Q96MT7-1]
DR ProteomicsDB; 77405; -. [Q96MT7-2]
DR Antibodypedia; 68151; 64 antibodies from 15 providers.
DR Ensembl; ENST00000295868.6; ENSP00000295868.2; ENSG00000206530.11. [Q96MT7-1]
DR Ensembl; ENST00000393845.9; ENSP00000377428.2; ENSG00000206530.11. [Q96MT7-2]
DR GeneID; 55779; -.
DR KEGG; hsa:55779; -.
DR MANE-Select; ENST00000393845.9; ENSP00000377428.2; NM_001164496.2; NP_001157968.1.
DR UCSC; uc003ead.2; human. [Q96MT7-2]
DR CTD; 55779; -.
DR DisGeNET; 55779; -.
DR GeneCards; CFAP44; -.
DR HGNC; HGNC:25631; CFAP44.
DR HPA; ENSG00000206530; Low tissue specificity.
DR MalaCards; CFAP44; -.
DR MIM; 617559; gene.
DR MIM; 617593; phenotype.
DR neXtProt; NX_Q96MT7; -.
DR OpenTargets; ENSG00000206530; -.
DR Orphanet; 276234; Non-syndromic male infertility due to sperm motility disorder.
DR PharmGKB; PA134928828; -.
DR VEuPathDB; HostDB:ENSG00000206530; -.
DR eggNOG; KOG2106; Eukaryota.
DR GeneTree; ENSGT00940000161555; -.
DR HOGENOM; CLU_000928_0_0_1; -.
DR InParanoid; Q96MT7; -.
DR OMA; FIMDRVH; -.
DR OrthoDB; 88812at2759; -.
DR PhylomeDB; Q96MT7; -.
DR TreeFam; TF323192; -.
DR PathwayCommons; Q96MT7; -.
DR SignaLink; Q96MT7; -.
DR BioGRID-ORCS; 55779; 10 hits in 1072 CRISPR screens.
DR ChiTaRS; CFAP44; human.
DR GenomeRNAi; 55779; -.
DR Pharos; Q96MT7; Tbio.
DR PRO; PR:Q96MT7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96MT7; protein.
DR Bgee; ENSG00000206530; Expressed in right uterine tube and 130 other tissues.
DR ExpressionAtlas; Q96MT7; baseline and differential.
DR Genevisible; Q96MT7; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IDA:MGI.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0060285; P:cilium-dependent cell motility; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IDA:MGI.
DR GO; GO:0007288; P:sperm axoneme assembly; IMP:UniProtKB.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 3.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW Cytoskeleton; Flagellum; Phosphoprotein; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..1854
FT /note="Cilia- and flagella-associated protein 44"
FT /id="PRO_0000305102"
FT REPEAT 226..267
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 270..309
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 315..358
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 365..402
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 468..507
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 513..553
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 573..612
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 804..843
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT REPEAT 856..895
FT /note="WD 9"
FT /evidence="ECO:0000255"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1500..1538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 931..958
FT /evidence="ECO:0000255"
FT COMPBIAS 1..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..740
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1083
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1505..1538
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1083
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:19690332"
FT VAR_SEQ 979..982
FT /note="DFDV -> VSLI (in isoform 1)"
FT /id="VSP_059893"
FT VAR_SEQ 983..1854
FT /note="Missing (in isoform 1)"
FT /id="VSP_059894"
FT VARIANT 53
FT /note="K -> E (in dbSNP:rs59722850)"
FT /id="VAR_062105"
FT VARIANT 284
FT /note="K -> N (in dbSNP:rs16845107)"
FT /id="VAR_053435"
FT VARIANT 463..1854
FT /note="Missing (in SPGF20)"
FT /evidence="ECO:0000269|PubMed:29449551"
FT /id="VAR_080886"
FT VARIANT 1059..1854
FT /note="Missing (in SPGF20)"
FT /evidence="ECO:0000269|PubMed:29449551"
FT /id="VAR_080887"
SQ SEQUENCE 1854 AA; 213865 MW; B086EB5D6455C187 CRC64;
MKEPDDQDTD GEKSVTSKSD GKKSLRSSKS ESRSPVQEDN TFLEDDTDET FTKGEGSYLE
EDSDEERLEG SLSSFQYGDL QSTTVPQQTP APAVEEAEEE VKKKISESFF YDYMELASMP
FVTLDSNIPL DLLTLVHSFG YDCRKRANLQ LLDDSIAIYI AGNQLIFLNL KTKEQIYLRS
SSGEGIGVIG VHPHKTYFTV AEKGSFPDII IYEYPSLRPY RVLRDGTEKG YAYVDFNYSG
NLLASVGSNP DYTLTIWNWK EEQPILRTKA FSQEVFKVTF NPDKEEQLTT SGSGHIKFWE
MAFTFTGLKL QGSLGRFGKT ITTDIEGYME LPDGKVLSGS EWGNMLLWEG GLIKVELCRG
TSKSCHNGPI NQIMLYEGEV ITVGSDGYVR IWDFETIDTA DVIDETGLLE IEPINELQVD
KNVNLFSMIK MNETGNNFWL AQDANGAIWK LDLSFSNITQ DPECLFSFHS GAIEAVAVSP
LTYLMATTAL DCSVRIYDFA SKTPLAQMKF KQGGTALVWV PRMVNFTGAQ IIVGFEDGVV
RILELYDPKG LTIFAGRKKI LDADIQLKQV FKPHTACVTA LAYERDGEIL ATGSKDQTVF
FFEVERDYKP IGYINTPGPV CQLMWSPMSH PESTLLIICE NGYILEAPLP TIKQEEDDHD
VVSYEIKDMC IKCFHFSSVK SKILRLIEIE KRERQRELKE KIREERRNKL AAEMGEDGEK
EFQEEEEEKE EEEEEEEPLP EIFIPSTPSP ILCGFYSEPG KFWVSLGGYD SGFLYHCEFP
PCDESSDFKE QKDEPIDVRY LADTEDNPIQ TITFNINKVM MFCGMKNGAI RVYVLNQNDP
SLTSLVDYWH FNMHDNNYGC IKSIANSFDD RFLVTAGADG NIFVFNIFSE FMLRKDMKAK
VPSPRFGIET EPIPEDIEDP KAYSIENARR KREHDKLMKE VGEIKARKRE QIKALRSEFC
NLLEMNEKLP KHMQFKRTDF DVDSQIRAEM HRKTAFKIQQ VEKELAWEKE KHELGLMKLK
NRFRDPLESD TIVVHAILSD HKISSYRLVQ PSKYSKFKRA SQSERKPSKL DRFEKEGPGR
KDSQRDAGGS VTIQEESIIE KGKKFRPKTL SEIIVENQIE KTRKLILKAE RAQLKIQQRK
KEWEELYKSK PGDDYEDPKD LQAIKEAQVY MGDFNLKTAP DYKIPEHMRI NAAKKEEELG
HLDSLVHGNK RHMNKCILSL RDLKVAVVEE IQCLVQELKN IQSTLHISKH IPIPKIPQIH
PEEVPEKRFQ YDEETLLNFK QQQMKSKDEK SPGVEQTGSG GPVGGFLKLS SRKDGDLTTR
DSISRSSKAS TFSLDIPKCL EFEKAEPTDV ELEIMKRDEI KHVYMQQYLV NRIKELVVTF
DAELRLLRHQ KLKLDTQMKL SDLHHVTLFQ EILLLKNFEK QENILQERVN SLDKEEQYMQ
WKINETLKEM EEKKNEITKL QEQEKALYAG FQAAIGENNK FANFLMKVLK KKIKRVKKKE
VEGDADEDEE SEESSEEESS LESDEDESES EDEVFDDSIC PTNCDVALFE LALHLREKRL
DIEEALVEEK KIVDNLKKEY DTLSKKVKIV ATNLNAAEEA LEAYQREKQQ RLNELLVVIP
LKLHQIEYVV FGEIPSDLSG TLVFSNHALR RLQERIHELQ EENSKQQKLN KEWRERRKQL
IREKREMTKT IHKMEETVRQ LMISKFGRVV NLEALQTLSV NTTLEELKIR KLRKELANAK
EMKMWEEKIA QMRWELMMKT KEHTRKLYQM NDLCIEKKKL DSRLNTLQNQ QGNAFQGPRE
ADVVAREEVT ELIQLQAERI SALKEEIALL RRKGSLILPP IQSPREKEIQ PADL
