ID   ACDD1_METTE             Reviewed;         436 AA.
AC   Q50538; P72023;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit delta 1;
DE            Short=ACDS complex subunit delta 1;
DE   AltName: Full=Corrinoid/iron-sulfur component small subunit 1;
GN   Name=cdhD1;
OS   Methanosarcina thermophila.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=2210;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-26.
RC   STRAIN=ATCC 43570 / DSM 1825 / OCM 12 / TM-1;
RX   PubMed=8550451; DOI=10.1128/jb.178.2.340-346.1996;
RA   Maupin-Furlow J., Ferry J.G.;
RT   "Characterization of the cdhD and cdhE genes encoding subunits of the
RT   corrinoid/iron-sulfur enzyme of the CO dehydrogenase complex from
RT   Methanosarcina thermophila.";
RL   J. Bacteriol. 178:340-346(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.
RC   STRAIN=ATCC 43570 / DSM 1825 / OCM 12 / TM-1;
RX   PubMed=8955306; DOI=10.1128/jb.178.23.6849-6856.1996;
RA   Maupin-Furlow J.A., Ferry J.G.;
RT   "Analysis of the CO dehydrogenase/acetyl-Coenzyme A synthase operon of
RT   Methanosarcina thermophila.";
RL   J. Bacteriol. 178:6849-6856(1996).
RN   [3]
RP   CHARACTERIZATION OF PARTIAL REACTIONS IN THE ACDS COMPLEX.
RX   PubMed=8626532; DOI=10.1074/jbc.271.14.8352;
RA   Grahame D.A., DeMoll E.;
RT   "Partial reactions catalyzed by protein components of the acetyl-CoA
RT   decarbonylase synthase enzyme complex from Methanosarcina barkeri.";
RL   J. Biol. Chem. 271:8352-8358(1996).
CC   -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage of
CC       acetyl-CoA, allowing growth on acetate as sole source of carbon and
CC       energy. Probably maintains the overall quaternary structure of the ACDS
CC       complex.
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from acetate.
CC   -!- SUBUNIT: Heterodimer of delta and gamma chains. The ACDS complex is
CC       made up of alpha, epsilon, beta, gamma and delta chains with a probable
CC       stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8)
CC       (Potential). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CdhD family. {ECO:0000305}.
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DR   EMBL; U30484; AAA93167.1; -; Genomic_DNA.
DR   EMBL; U66032; AAC44654.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q50538; -.
DR   SMR; Q50538; -.
DR   PRIDE; Q50538; -.
DR   KEGG; ag:AAA93167; -.
DR   BioCyc; MetaCyc:CDHDMSARC-MON; -.
DR   BRENDA; 2.1.1.245; 3281.
DR   UniPathway; UPA00642; -.
DR   GO; GO:0018492; F:carbon-monoxide dehydrogenase (acceptor) activity; IDA:MENGO.
DR   GO; GO:0019385; P:methanogenesis, from acetate; IEA:UniProtKB-UniRule.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.20; -; 1.
DR   HAMAP; MF_01135; CdhD; 1.
DR   InterPro; IPR016041; Ac-CoA_synth_d_su_TIM-brl.
DR   InterPro; IPR004486; CO_DH/Ac-CoA_synth_dsu.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   Pfam; PF03599; CdhD; 1.
DR   SUPFAM; SSF51717; SSF51717; 1.
DR   TIGRFAMs; TIGR00381; cdhD; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Methanogenesis.
FT   CHAIN           1..436
FT                   /note="Acetyl-CoA decarbonylase/synthase complex subunit
FT                   delta 1"
FT                   /id="PRO_0000155115"
SQ   SEQUENCE   436 AA;  46954 MW;  5F1E095ADFD684ED CRC64;
     MAKKMKLSDI TNMFVGMDVE ALEGVTIEGD IEIDLGGLGG GFDPMLAAAL GQESAVLAQH
     FARLAGMFGY PVGFGGAAAP AISPALAAPK LKDLIPAKFD VANIAEWTTE IQEVPIGNTS
     ADGGSRGKRV LVGGEKALPF YFDAPMPNRN QVTIDVFDMR IGLAKAVKEN YDEVMDSPGE
     WAKKNVEKFN ADMITIHLIS TDPLIKDTPA KEAAKTVEEV LQAVDVPIAI GGSGNPQKDP
     EVLAKAAEVA EGERCLLASA SLNLDYAAIA EAALKYDHDV LSWTQLDMNA QKELNRKLMK
     QCNVPRDRII MDPTTAALGY GLDYAYTNME RIRLAALMGD DELTFPMSSG TTNAWGARES
     WMVGSPLSQD TDWGPREYRG PIWEIVTGLS LAIAGNDLFM MMHPTSVAVL KQITQTLFGS
     IEAEPVDITN WIGAEV