CFA46_HUMAN
ID CFA46_HUMAN Reviewed; 2715 AA.
AC Q8IYW2; B1AP44; B7WPK8; Q5JSF7; Q5SR76; Q5SR77; Q86ST2; Q8N777; Q9NTQ5;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-FEB-2012, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Cilia- and flagella-associated protein 46 {ECO:0000305};
DE AltName: Full=Tetratricopeptide repeat protein 40 {ECO:0000312|HGNC:HGNC:25247};
GN Name=CFAP46 {ECO:0000312|HGNC:HGNC:25247};
GN Synonyms=C10orf123 {ECO:0000312|HGNC:HGNC:25247},
GN C10orf124 {ECO:0000312|HGNC:HGNC:25247},
GN C10orf92 {ECO:0000312|HGNC:HGNC:25247},
GN C10orf93 {ECO:0000312|HGNC:HGNC:25247},
GN TTC40 {ECO:0000312|HGNC:HGNC:25247};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ASN-264.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1812-2715 (ISOFORM 1), AND VARIANTS THR-2331 AND
RP GLY-2540.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2134-2715 (ISOFORM 1), AND
RP VARIANTS THR-2331 AND GLY-2540.
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
CC -!- FUNCTION: As part of the central apparatus of the cilium axoneme plays
CC a role in cilium movement. {ECO:0000250|UniProtKB:A8ICS9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:A8ICS9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8IYW2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IYW2-2; Sequence=VSP_042257, VSP_042258;
CC Name=3;
CC IsoId=Q8IYW2-3; Sequence=VSP_042255, VSP_042256;
CC -!- SIMILARITY: Belongs to the CFAP46 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH34223.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC05424.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK098820; BAC05424.1; ALT_SEQ; mRNA.
DR EMBL; AL392043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL691429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC034223; AAH34223.1; ALT_INIT; mRNA.
DR EMBL; BC044661; AAH44661.1; -; mRNA.
DR EMBL; AL122111; CAB59272.3; -; mRNA.
DR CCDS; CCDS58101.1; -. [Q8IYW2-1]
DR PIR; T34538; T34538.
DR RefSeq; NP_001186978.2; NM_001200049.2. [Q8IYW2-1]
DR SMR; Q8IYW2; -.
DR BioGRID; 120145; 9.
DR IntAct; Q8IYW2; 7.
DR STRING; 9606.ENSP00000357575; -.
DR iPTMnet; Q8IYW2; -.
DR PhosphoSitePlus; Q8IYW2; -.
DR BioMuta; CFAP46; -.
DR DMDM; 378405228; -.
DR MassIVE; Q8IYW2; -.
DR MaxQB; Q8IYW2; -.
DR PaxDb; Q8IYW2; -.
DR PeptideAtlas; Q8IYW2; -.
DR PRIDE; Q8IYW2; -.
DR Antibodypedia; 48598; 55 antibodies from 8 providers.
DR DNASU; 255352; -.
DR DNASU; 54777; -.
DR Ensembl; ENST00000368585.3; ENSP00000357574.3; ENSG00000171811.14. [Q8IYW2-2]
DR Ensembl; ENST00000368586.10; ENSP00000357575.4; ENSG00000171811.14. [Q8IYW2-1]
DR GeneID; 54777; -.
DR KEGG; hsa:54777; -.
DR MANE-Select; ENST00000368586.10; ENSP00000357575.4; NM_001200049.3; NP_001186978.2.
DR UCSC; uc001llt.4; human. [Q8IYW2-1]
DR CTD; 54777; -.
DR DisGeNET; 54777; -.
DR GeneCards; CFAP46; -.
DR HGNC; HGNC:25247; CFAP46.
DR HPA; ENSG00000171811; Tissue enhanced (choroid plexus, skeletal muscle, testis).
DR MIM; 618543; gene.
DR neXtProt; NX_Q8IYW2; -.
DR OpenTargets; ENSG00000171811; -.
DR VEuPathDB; HostDB:ENSG00000171811; -.
DR eggNOG; ENOG502QS2Z; Eukaryota.
DR GeneTree; ENSGT00570000079216; -.
DR HOGENOM; CLU_000530_1_0_1; -.
DR InParanoid; Q8IYW2; -.
DR OMA; EKNYGQA; -.
DR OrthoDB; 462717at2759; -.
DR PhylomeDB; Q8IYW2; -.
DR PathwayCommons; Q8IYW2; -.
DR SignaLink; Q8IYW2; -.
DR BioGRID-ORCS; 54777; 10 hits in 1063 CRISPR screens.
DR ChiTaRS; CFAP46; human.
DR GenomeRNAi; 54777; -.
DR Pharos; Q8IYW2; Tdark.
DR PRO; PR:Q8IYW2; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8IYW2; protein.
DR Bgee; ENSG00000171811; Expressed in right uterine tube and 106 other tissues.
DR ExpressionAtlas; Q8IYW2; baseline and differential.
DR Genevisible; Q8IYW2; HS.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0035082; P:axoneme assembly; ISS:UniProtKB.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IEA:InterPro.
DR InterPro; IPR039586; CFAP46.
DR PANTHER; PTHR15977; PTHR15977; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium;
KW Cilium biogenesis/degradation; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..2715
FT /note="Cilia- and flagella-associated protein 46"
FT /id="PRO_0000089812"
FT REPEAT 89..122
FT /note="TPR 1"
FT REPEAT 175..208
FT /note="TPR 2"
FT REPEAT 261..295
FT /note="TPR 3"
FT REPEAT 324..359
FT /note="TPR 4"
FT REPEAT 426..459
FT /note="TPR 5"
FT REPEAT 469..503
FT /note="TPR 6"
FT REPEAT 807..845
FT /note="TPR 7"
FT REPEAT 936..969
FT /note="TPR 8"
FT REPEAT 1111..1144
FT /note="TPR 9"
FT REPEAT 1174..1211
FT /note="TPR 10"
FT REPEAT 1639..1672
FT /note="TPR 11"
FT REPEAT 2399..2432
FT /note="TPR 12"
FT REPEAT 2504..2537
FT /note="TPR 13"
FT REGION 1356..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2000..2023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2294..2319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2371..2399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2541..2567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1362..1401
FT /evidence="ECO:0000255"
FT COILED 1781..1810
FT /evidence="ECO:0000255"
FT COMPBIAS 1359..1403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2371..2386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2543..2557
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 222..247
FT /note="RHELMDELQLKEEKKNSISLSVTFYI -> NQRIRNRDVRSNFLKSHCSENC
FT VEIT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042255"
FT VAR_SEQ 248..2715
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042256"
FT VAR_SEQ 323..405
FT /note="DPGKLIEMECLECESEALRLESKMKVYNRAAVEAQLDIIQRLDVALQRAVRL
FT GDPRVIHVVCATQWNTCLPLLQHNLRHHLRK -> VSGFMTLLPGDEALLTVQLDKRQR
FT KEEQFTRPRPPGLRSVVGTLPSFLPVFCTVAVRWCLQFYTCPFLFTFLVATGPQHHSCF
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042257"
FT VAR_SEQ 406..2715
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042258"
FT VARIANT 264
FT /note="S -> N (in dbSNP:rs12781609)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_046201"
FT VARIANT 2125
FT /note="C -> R (in dbSNP:rs10870341)"
FT /id="VAR_056823"
FT VARIANT 2249
FT /note="E -> K (in dbSNP:rs12356978)"
FT /id="VAR_056824"
FT VARIANT 2331
FT /note="A -> T (in dbSNP:rs4880433)"
FT /evidence="ECO:0000269|PubMed:11230166,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_023208"
FT VARIANT 2499
FT /note="L -> F (in dbSNP:rs3750587)"
FT /id="VAR_056825"
FT VARIANT 2540
FT /note="S -> G (in dbSNP:rs2254419)"
FT /evidence="ECO:0000269|PubMed:11230166,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_023209"
FT VARIANT 2658
FT /note="K -> Q (in dbSNP:rs35981039)"
FT /id="VAR_056826"
SQ SEQUENCE 2715 AA; 303500 MW; 693A814CD7068AEC CRC64;
MDLVITQELA RAESQQDAAS LKKAYELIKS ANLGKSEFDP SESFSPDLFV LCAEQALKMR
QPEVSEDCIQ MYFKVKAPIT QFLGRAHLCR AQMCAPKSAE NLEEFENCVT EYMKAINFAK
GEPRYYFLVY NASVLYWQMV RPFLKPGYRH HLIPSLSQII NVLSQTEEED KEWRAELMLE
LLECYLQAGR KEEAARFCST AAPFIKSHVP QKYRQIFSVM VRHELMDELQ LKEEKKNSIS
LSVTFYINML KAKAEQNDLP GDISVILRKA YRHLGHYNHQ RFPSISEEKM LLLFELARFS
LTLKCMEISS ACLSDLKKME SKDPGKLIEM ECLECESEAL RLESKMKVYN RAAVEAQLDI
IQRLDVALQR AVRLGDPRVI HVVCATQWNT CLPLLQHNLR HHLRKPLAGV ADVLEKLDSL
MTLLRCQVHM EMAQIEEDED RLEPATEHLR KAARLDSLGL YRDRIQMAST RLRLCTTLYQ
APERAEDKAI MAVEQAKKAT PKDSVRKKRA LLVNAGLALA PDAFQIVLDS ENEAKVSTGK
NRGRFTYLCA KAWHHTVSVD KAAGHLRRLG NENDKERIQI WAELAKVARK QGVWDVCRTA
SRFCLLYDNV KVKKLRLRRG KKKRGRDGSV QDTWSQPEVV LQRQVCPDLL RKFAEVGFIH
AEATVHLLRS EGVELNDRAI PPEDLSQHPA GYVPEPPEVN AEWITYRTWI ESLSRCAMNN
WLRSAEIGQE IQEAWIVQNA VVYVLNHNHH LILAGRQKEL VDALYHLLSI VKATGHSGDP
VMLVTLCNTL ARGLIISWIP VQAAEKSRKF MRPNAFHSPL DAGATSEIKT AVEVCEFALN
LTNGSAPEET VPTGTRQQLI ATWVKAKQLL QQQIGPRLGT EEQGTNEDVS SVTRVLVALE
MYSCNGLGLM DFTVPSLAQL VKMASECNWS DPLVELQTLT RLTHFAHAAR DHETTMACAH
RALEMGIKYL KKFGPEESRL VAEMLCTATA IQGRSIMENL KGRKQLRLVA AKAFTESARF
GGIAGSSALV MLAARHYWNA WLPLLSSAVY RKKAKGALKR LIGIINKTEA RKQEKGKTLL
LHQWPTADFQ GGGTTEGYFL PGAEDDLALR AALYGLLFHS HADQDDWEGG LKVLDEAVQV
LPRTAHRLLI FKHMVIVKAK LGQNFSMEIQ KFKAESEDYL ARMWHRLALN SPSVSGELAC
YNNAIQALQK PEMEWQKVEY LMEFGQWLHH RHFPLEDVVF HLRWAVEILL AMKPPGDVPE
PQPTPDGEYV AVEMPPRSPV SEAEEAVSLE QLRSVRQLEA LARVHILLAL VLSPGAEGYE
DCCLAAYAFF RHIWQVSLMT AGKSVLENRP LAATSSHLLL PKKEKENERS KEKEKERSKE
KENERSKEKD KEKGKEEKVK EPKQSQSPAP IKQLEDLPMS IEEWASYSCP EEVLSVLKQD
RSDSTVNPSS IQKPTYSLYF LDHLVKALQK MCLHELTVPV LQLGVLISDS VVGSKGLSDL
YHLRLAHACS ELKLREAAAR HEEAVGQVCV SELEQASCRK EIALKKEKNK EPLLEESLPA
LNEQTLPVQP GEIKPLDAKD KILKMNGETG RDLDGTSFPH LWMLKAEVLL EMNLYQPARL
LLSEAYLAFQ ELDEPCAEAQ CLLLLAQLAN KEKNYGQAKK MIAQAQHLGG SEEFWYNSTL
TLAEALLSME HSGREATVCH IFQKLINAFK ILKKERPNRL PLLEFMITDL EARCLSLRVR
VAQHSAVTEP TECSLLLKEM DDGLLEIERK FIDCGCKENC VDVKLERAKI KRLRAQNEKD
EEQKTAYYLE AYGLAQGAVA EEEGRLHSIQ GLYGLAQGAM AEEEGRLHSV QGLLSLQDLQ
NVNTPLMRKL ARLKLGLVEM ALDMLQFIWE EAHGQQSEQG SLEKLLADYL QNTSDYTSVG
LQWFTLKRTL AHGALAQLGS LQPLSVGCVE IRARLLGLAG RALHLLAMQA DPVHPTCYWE
AGPSVGAKLS GLKSLELEVE EEGATKSSRD PPASRAAPEE HCRRGEDLKR RMVLAQQYLA
QASEVLLQCL QVALGSGLLD VAAAASLEMV ECVGTLDPAT TCQFLALSQS CSASETMRDV
LLAATANTSS SQLAALLQLQ HQLRCQDRTT TSLGARVEQR LAAVSKAWQN LCVTEQHFNL
LNEMPPTFWI LFLHLSGDRS RLYGAAYEKP KFITAAKGKV QAVGGSCKVM RLAISPTAFS
HLLACAQQFR KQTQAQVYSE DMALNIGSEP EGLQVEEKER PVQRLSSVLG PLEELLQPLF
PLLSLSKARV QTPAVVADSG KSKGKDKERK TSTGQHSTVQ PEVADKIVLV ADRHLLELPL
EGLSVFDEGT ISSVSREFSL QMLWNRLHKE ETEGGVKKEG RSRDPKKRSL AKKGRKGSIP
RTIPPDCIIV DSDNFKFVVD PYEEAQGPEM LTPVSITQDI LERFQDTFTS RWAGHLGSKH
FPSQAQWEQA LGSCSGFFFY GMESFLSHIL VERLVAMNLQ ECQVAVLLDL ARSYQSLKRH
MESVEHRRSV GRWEANWRNS ASPSEDEWRR GGEPRRGFSD LEGQAAAAPK LRAPSHHAQL
GPVWAAAPSH RVVQAWTCLP SAAGAPALAS ALGSAPLPTH PHLPAPIPSS QLALPFLGLS
PALGAASARD PPPATSRKAA AWTSSSACLC APWGLRRGWS CVSSRGQDKG GLPLAALVLS
CLDQKTIQTV SLFLI
