CFA52_BOVIN
ID CFA52_BOVIN Reviewed; 623 AA.
AC E1BKF9;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Cilia- and flagella-associated protein 52;
GN Name=CFAP52 {ECO:0000312|VGNC:VGNC:27245};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000312|Proteomes:UP000009136};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [2] {ECO:0007744|PDB:7RRO}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT "De novo identification of mammalian ciliary motility proteins using cryo-
RT EM.";
RL Cell 184:5791-5806.e19(2021).
CC -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC doublet microtubules (DMTs) in cilia axoneme, which is required for
CC motile cilia beating (PubMed:34715025). Important for proper ciliary
CC and flagellar beating. May act in cooperation with CFAP45 and axonemal
CC dynein subunit DNAH11. May play a role in cell growth and/or survival
CC (By similarity). {ECO:0000250|UniProtKB:Q8N1V2,
CC ECO:0000269|PubMed:34715025}.
CC -!- SUBUNIT: Interacts with BRCA2. Interacts with the CCT chaperonin
CC complex. Interacts with HSP70. Interacts with AK8. Interacts with
CC CFAP45. Interacts with DNAI1 (By similarity). Interacts with IQDC (By
CC similarity). {ECO:0000250|UniProtKB:F1SS88,
CC ECO:0000250|UniProtKB:Q8N1V2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:34715025}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q8N1V2}. Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:A8ILK1}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q8N1V2}. Note=Located in the proximal region of
CC respiratory cilia. {ECO:0000250|UniProtKB:Q8N1V2}.
CC -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC {ECO:0000269|PubMed:34715025}.
CC -!- SIMILARITY: Belongs to the CFAP52 family. {ECO:0000305}.
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DR PDB; 7RRO; EM; 3.40 A; e/f/g=1-623.
DR PDBsum; 7RRO; -.
DR SMR; E1BKF9; -.
DR STRING; 9913.ENSBTAP00000023697; -.
DR PaxDb; E1BKF9; -.
DR Ensembl; ENSBTAT00000023697.5; ENSBTAP00000023697.4; ENSBTAG00000017823.5.
DR VEuPathDB; HostDB:ENSBTAG00000017823; -.
DR VGNC; VGNC:27245; CFAP52.
DR eggNOG; KOG0266; Eukaryota.
DR GeneTree; ENSGT00940000157016; -.
DR HOGENOM; CLU_009244_2_0_1; -.
DR InParanoid; E1BKF9; -.
DR OMA; LLRIMVY; -.
DR OrthoDB; 185227at2759; -.
DR TreeFam; TF323254; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000017823; Expressed in oviduct epithelium and 43 other tissues.
DR GO; GO:0097729; C:9+2 motile cilium; IEA:Ensembl.
DR GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0061966; P:establishment of left/right asymmetry; IEA:Ensembl.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR033015; CFAP52.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13720:SF14; PTHR13720:SF14; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 12.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..623
FT /note="Cilia- and flagella-associated protein 52"
FT /id="PRO_0000456167"
FT REPEAT 65..109
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 112..153
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 159..198
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 291..330
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 333..372
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 375..414
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 418..457
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 462..501
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT REPEAT 503..544
FT /note="WD 9"
FT /evidence="ECO:0000255"
FT REPEAT 546..585
FT /note="WD 10"
FT /evidence="ECO:0000255"
FT REPEAT 588..623
FT /note="WD 11"
FT /evidence="ECO:0000255"
SQ SEQUENCE 623 AA; 68637 MW; B7EDCDD3BF1B114D CRC64;
METQASPKDE VAEAVELELE AVIGFNGHVP TGLKCHPDQE HLVYPLGCTI LIQAINTQEQ
NFLHGHGNNV SCVAISKSGL YIASGQVTFM GFKADIILWD YKKRELMARL SLHKGKIEAL
AFSPNDMYLV SLGGPDDGSV VVWSIAKREA ICGSPAAGLN VGNATTVIFS KCRDEMFVTA
GNGTIRVWEL DLPNRKIWPT ECQTGQMKRI VMSISMANDD SFFYLGTTTG DILKMNPRTK
LLADTGPAKD KFSLGVSAIC CLKMGGLLVG SGDGLLVFCK SPSYKPIKKI QLQGGITSIT
LRGEGHQFFV GTEESHIYRV NFTNFKETLI TTCHFESVED IVFPFGTAEL FATCAKKDIR
VWHTLTNREL LRITVPNMTC HGIDFMRDGK SIISAWDDGR IRAFAPETGR LMYVINNAHR
IGVTAIATTS DCKRVISGGG EGEVRVWHIG HQTQKLEEAL KEHKSSVSCI RVKKSNEECV
TASTDGTCII WDLVRLRRNQ MILANTLFQC VCYHPEEFQI ITSGTDRKIA YWEVFDGSVI
RELDGSLSGA VNGMDITVEG VHFVTGGNDH LVKVWDYNEG EVTHVGVGHS GNITRIRISP
GNQYIVSVSA DGAILRWKYP FPS
