CFA52_CHLRE
ID CFA52_CHLRE Reviewed; 615 AA.
AC A8ILK1;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Cilia- and flagella-associated protein 52 {ECO:0000305};
GN Name=CFAP52 {ECO:0000305}; Synonyms=FAP52 {ECO:0000312|EMBL:EDP05376.1};
GN ORFNames=CHLREDRAFT_128114 {ECO:0000312|EMBL:EDP05376.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=15998802; DOI=10.1083/jcb.200504008;
RA Pazour G.J., Agrin N., Leszyk J., Witman G.B.;
RT "Proteomic analysis of a eukaryotic cilium.";
RL J. Cell Biol. 170:103-113(2005).
CC -!- FUNCTION: May play a role in cell growth and/or survival.
CC {ECO:0000250|UniProtKB:Q8N1V2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N1V2}. Cell
CC projection, cilium, flagellum {ECO:0000269|PubMed:15998802}.
CC -!- SIMILARITY: Belongs to the CFAP52 family. {ECO:0000305}.
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DR EMBL; DS496118; EDP05376.1; -; Genomic_DNA.
DR RefSeq; XP_001690930.1; XM_001690878.1.
DR AlphaFoldDB; A8ILK1; -.
DR SMR; A8ILK1; -.
DR STRING; 3055.EDP05376; -.
DR PaxDb; A8ILK1; -.
DR PRIDE; A8ILK1; -.
DR GeneID; 5716690; -.
DR eggNOG; KOG0266; Eukaryota.
DR HOGENOM; CLU_009244_2_0_1; -.
DR InParanoid; A8ILK1; -.
DR OrthoDB; 185227at2759; -.
DR GO; GO:0005930; C:axoneme; IDA:GeneDB.
DR GO; GO:0036064; C:ciliary basal body; IDA:GeneDB.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR033015; CFAP52.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13720:SF14; PTHR13720:SF14; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cytoplasm; Flagellum; Repeat; WD repeat.
FT CHAIN 1..615
FT /note="Cilia- and flagella-associated protein 52"
FT /id="PRO_0000431302"
FT REPEAT 54..98
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 101..142
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 145..184
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 232..275
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 320..359
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 362..401
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 405..444
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 449..488
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT REPEAT 490..529
FT /note="WD 9"
FT /evidence="ECO:0000255"
FT REPEAT 533..572
FT /note="WD 10"
FT /evidence="ECO:0000255"
FT REPEAT 575..614
FT /note="WD 11"
FT /evidence="ECO:0000255"
SQ SEQUENCE 615 AA; 66475 MW; D251D2A554FCE5C6 CRC64;
MAEPLVLNSV IGFGGAIENG LIAHPDGRTI IYPLGSTIVL RDRADPRSQE FLQGHSDKVS
CLALSRSGRY LASGQITYMG FTADIIIWDL ESKQLIHRMA LHKVKVQALD FSCDERFLAS
LGGQDDNALV LWDVASGNAI CGSPCNTNFT NCVKFFNNSP DKLITAGNFN MNVWTYDAGN
NKLRPTDATL GTLKRVFKSV VVDANDEYAY CGTTTGDVLQ IALERVLFKN TGPAKGNVQM
GVTATCEVPT GDILVGGGDG SLQLLRKMPA LAGTKVEGAI TSIALADMNA RGFTFFVGTA
MCNIYKPATS RLKEELVQTA HNDKINGMAF PNEYSEVFAT CGTGFIRLWH LTTCRELLRI
AVPNLECFCI AFTTDGSAIL SGWSDGKIRA FGPQSGKIIF TINDAHQKAV TAIASTADSS
RILSGGEEGM VRVWRIGRTS QTLEASMKDH KGPVNCIRIK GSGDECVSAS SDGSCILWDL
HTFKRRTSLF ANTFFKSVVY HPDESQLVTA GTDRKVTYWD AYDGNAIRII DGSDLDEVNA
LAVDRDGEAL VSGGGDKLVK LWGYDEGHCY FVGVAHSGAI TAVGVTPDKQ RIVSVGTEGG
IFIWDYQRPQ TLADI
