ID   CFA52_MACFA             Reviewed;         571 AA.
AC   Q95JL5;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Cilia- and flagella-associated protein 52 {ECO:0000250|UniProtKB:Q8N1V2};
DE   AltName: Full=WD repeat-containing protein 16 {ECO:0000250|UniProtKB:Q8N1V2};
GN   Name=CFAP52 {ECO:0000250|UniProtKB:Q8N1V2};
GN   Synonyms=WDR16 {ECO:0000250|UniProtKB:Q8N1V2}; ORFNames=QtsA-15738;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated
CC       doublet microtubules (DMTs) in cilia axoneme, which is required for
CC       motile cilia beating (By similarity). Important for proper ciliary and
CC       flagellar beating. May act in cooperation with CFAP45 and axonemal
CC       dynein subunit DNAH11. May play a role in cell growth and/or survival
CC       (By similarity). {ECO:0000250|UniProtKB:E1BKF9,
CC       ECO:0000250|UniProtKB:Q8N1V2}.
CC   -!- SUBUNIT: Interacts with BRCA2 (By similarity). Interacts with the CCT
CC       chaperonin complex (By similarity). Interacts with HSP70 (By
CC       similarity). Interacts with AK8 (By similarity). Interacts with CFAP45
CC       (By similarity). Interacts with DNAI1 (By similarity). Interacts with
CC       IQDC (By similarity). {ECO:0000250|UniProtKB:F1SS88,
CC       ECO:0000250|UniProtKB:Q8N1V2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N1V2}. Cell
CC       projection, cilium, flagellum {ECO:0000250|UniProtKB:A8ILK1}.
CC       Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q8N1V2}.
CC       Note=Located in the proximal region of respiratory cilia.
CC       {ECO:0000250|UniProtKB:Q8N1V2}.
CC   -!- SIMILARITY: Belongs to the CFAP52 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB070166; BAB63111.1; -; mRNA.
DR   RefSeq; NP_001306317.1; NM_001319388.1.
DR   AlphaFoldDB; Q95JL5; -.
DR   SMR; Q95JL5; -.
DR   STRING; 9541.XP_005582936.1; -.
DR   GeneID; 102137679; -.
DR   CTD; 146845; -.
DR   eggNOG; KOG0266; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR033015; CFAP52.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   PANTHER; PTHR13720:SF14; PTHR13720:SF14; 2.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 9.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..571
FT                   /note="Cilia- and flagella-associated protein 52"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000233154"
FT   REPEAT          62..106
FT                   /note="WD 1"
FT   REPEAT          109..150
FT                   /note="WD 2"
FT   REPEAT          156..195
FT                   /note="WD 3"
FT   REPEAT          288..327
FT                   /note="WD 4"
FT   REPEAT          330..364
FT                   /note="WD 5"
FT   REPEAT          366..405
FT                   /note="WD 6"
FT   REPEAT          410..449
FT                   /note="WD 7"
FT   REPEAT          451..490
FT                   /note="WD 8"
FT   REPEAT          494..533
FT                   /note="WD 9"
FT   REPEAT          536..571
FT                   /note="WD 10"
SQ   SEQUENCE   571 AA;  62672 MW;  FB3974FDDDE83A98 CRC64;
     MDNKISPEAQ VAELELDAVI GFNGHVPTGL KCHPDQEHLI FPLGCTILIQ AINTQEQNFL
     QGHGNNVSCL AISRSGRYIA SGQVTFMGFK ADIILWDYKK RELLARLSLH KGKIEALAFS
     PNDLYLVSLG GPDDGSVVVW SIAKRDAICG SPAAGLNVGN ATNVIFSRCR DEMFVTAGNG
     TIRVWELDLP NRKIWPTECQ TGQMKRIVMS IGMADDDSFF YLGTTTGDIL KMNPRTKLLT
     DAGPAKDKFS LGVSAIRCLK MGGLLVGSGA GLLVFCKSPS YKPIKKIQSQ GGITSITLRG
     EGHQFFVGTE ESHIYRVSFT DFKETLIATC HFEAVEDIVF PFGTAELFAT CAKKDIRVWH
     TSSNSAHRIG VTAIATTSDC KRVISGGGEG EVRVWQIGCQ TQKLEEALKE HKSSVSCIRV
     KKNNEECVTA STDGTCIIWD LVRLRRNQMI LANTLFQCVC YHPEEFQIIT SGTDRKIAYW
     EVFDGTVIRE LEGSLSGSIN GMDITQEGVH FVTGGNDHLV KVWDYNEGEV THVGVGHSGN
     ITRIRISPGN QYIVSVSADG AILRWKYPYT S