ID   CFA53_CHLRE             Reviewed;         482 AA.
AC   A8IRJ7;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Cilia- and flagella-associated protein 53 {ECO:0000305};
GN   Name=CFAP53 {ECO:0000305}; Synonyms=FAP53 {ECO:0000312|EMBL:EDP04486.1};
GN   ORFNames=CHLREDRAFT_196792 {ECO:0000312|EMBL:EDP04486.1};
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC-503;
RX   PubMed=17932292; DOI=10.1126/science.1143609;
RA   Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA   Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA   Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA   Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA   Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA   Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA   Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA   Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA   Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA   Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA   Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA   Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA   Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA   Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA   Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA   Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA   Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA   Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA   Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA   Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA   Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT   "The Chlamydomonas genome reveals the evolution of key animal and plant
RT   functions.";
RL   Science 318:245-250(2007).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=15998802; DOI=10.1083/jcb.200504008;
RA   Pazour G.J., Agrin N., Leszyk J., Witman G.B.;
RT   "Proteomic analysis of a eukaryotic cilium.";
RL   J. Cell Biol. 170:103-113(2005).
CC   -!- FUNCTION: May play a role in filopodium movement.
CC       {ECO:0000250|UniProtKB:Q96M91}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000269|PubMed:15998802}.
CC   -!- SIMILARITY: Belongs to the CFAP53 family. {ECO:0000305}.
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DR   EMBL; DS496121; EDP04486.1; -; Genomic_DNA.
DR   RefSeq; XP_001691996.1; XM_001691944.1.
DR   PDB; 6U42; EM; 3.40 A; 4L/4M=1-482.
DR   PDBsum; 6U42; -.
DR   AlphaFoldDB; A8IRJ7; -.
DR   SMR; A8IRJ7; -.
DR   STRING; 3055.EDP04486; -.
DR   PaxDb; A8IRJ7; -.
DR   PRIDE; A8IRJ7; -.
DR   EnsemblPlants; PNW85409; PNW85409; CHLRE_03g185050v5.
DR   GeneID; 5717436; -.
DR   Gramene; PNW85409; PNW85409; CHLRE_03g185050v5.
DR   KEGG; cre:CHLRE_03g185050v5; -.
DR   eggNOG; ENOG502R2FD; Eukaryota.
DR   HOGENOM; CLU_561916_0_0_1; -.
DR   InParanoid; A8IRJ7; -.
DR   OMA; MQIAHQQ; -.
DR   OrthoDB; 1174069at2759; -.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   InterPro; IPR033365; CFAP53.
DR   InterPro; IPR043596; CFAP53/TCHP.
DR   InterPro; IPR043597; TPH_dom.
DR   PANTHER; PTHR31183; PTHR31183; 1.
DR   PANTHER; PTHR31183:SF1; PTHR31183:SF1; 1.
DR   Pfam; PF13868; TPH; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell projection; Cilium; Coiled coil; Flagellum.
FT   CHAIN           1..482
FT                   /note="Cilia- and flagella-associated protein 53"
FT                   /id="PRO_0000431313"
FT   REGION          462..482
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          9..40
FT                   /evidence="ECO:0000255"
FT   COILED          67..124
FT                   /evidence="ECO:0000255"
FT   COILED          152..413
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   482 AA;  56548 MW;  96D138EA2AB8420D CRC64;
     MNKSRAPPDA RIQKMRELEE RLANLKADRK VEQKMVAVAE FEARTTKKIV GNLVQQRYDA
     LKARAEADLN ARRQRLADKL DAEDLAMRQE LLASKKTPEQ RRAELAERAR ALAATREAER
     QALASTLYEK AFIQSCDVLR DENSKRILYR TIEERNAQIE HKMAQRIMEA EEKRMWHEMS
     EVERQKMEQR YLDDKRRDRE KREEVLRILD EQVRQVNARR AEASMLRRAE IAELNATWRQ
     MAADQEAADV QERENMKKLA AELQEFNRIK QMEISEAERS ERELDLKILQ EALSKEAADE
     AAELAFRERR REEMRRYREQ LALMMEKERE ETAERDALIL KAQLEQEAKR DAELAARDEA
     RRQLMAQVDA IRQIQIQEKL AKRLERAEEK AFERAQMAEE VAKAESDAAA KDAADRKAGI
     QRRLELQTMM VAKAHMKAAE LDEKLAEGEA TKRVEDQFKA KVNQTLSSTD PPVWHGRRKF
     DW