ID   ACDD2_METTE             Reviewed;         437 AA.
AC   Q9C4Z1;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit delta 2;
DE            Short=ACDS complex subunit delta 2;
DE   AltName: Full=Corrinoid/iron-sulfur component small subunit 2;
GN   Name=cdhD2;
OS   Methanosarcina thermophila.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=2210;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43570 / DSM 1825 / OCM 12 / TM-1;
RX   PubMed=12464601; DOI=10.1074/jbc.m210484200;
RA   Gencic S., Grahame D.A.;
RT   "Nickel in subunit beta of the acetyl-CoA decarbonylase/synthase
RT   multienzyme complex in methanogens. Catalytic properties and evidence for a
RT   binuclear Ni-Ni site.";
RL   J. Biol. Chem. 278:6101-6110(2003).
CC   -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage of
CC       acetyl-CoA, allowing growth on acetate as sole source of carbon and
CC       energy. Probably maintains the overall quaternary structure of the ACDS
CC       complex (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from acetate.
CC   -!- SUBUNIT: Heterodimer of delta and gamma chains. The ACDS complex is
CC       made up of alpha, epsilon, beta, gamma and delta chains with a probable
CC       stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8)
CC       (Potential). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CdhD family. {ECO:0000305}.
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DR   EMBL; AF173830; AAG53713.1; -; Genomic_DNA.
DR   RefSeq; WP_048168054.1; NZ_CP009502.1.
DR   AlphaFoldDB; Q9C4Z1; -.
DR   SMR; Q9C4Z1; -.
DR   GeneID; 41602252; -.
DR   UniPathway; UPA00642; -.
DR   GO; GO:0018492; F:carbon-monoxide dehydrogenase (acceptor) activity; IDA:MENGO.
DR   GO; GO:0019385; P:methanogenesis, from acetate; IEA:UniProtKB-UniRule.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.20; -; 1.
DR   HAMAP; MF_01135; CdhD; 1.
DR   InterPro; IPR016041; Ac-CoA_synth_d_su_TIM-brl.
DR   InterPro; IPR004486; CO_DH/Ac-CoA_synth_dsu.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   Pfam; PF03599; CdhD; 1.
DR   SUPFAM; SSF51717; SSF51717; 1.
DR   TIGRFAMs; TIGR00381; cdhD; 1.
PE   3: Inferred from homology;
KW   Methanogenesis.
FT   CHAIN           1..437
FT                   /note="Acetyl-CoA decarbonylase/synthase complex subunit
FT                   delta 2"
FT                   /id="PRO_0000155116"
SQ   SEQUENCE   437 AA;  47184 MW;  B59EF6B99DC0BBCE CRC64;
     MAKKMKLSEI TNMFAGMNVE ALEGVTIEGD IEIDLGGLGG FDPMLAAALG QESAVLAQHF
     ARIAGMFGYP VSVGAPAAAP AAVSPALAAP KLKDLIPAKF EFSNIEEWTT QVEEVPIGNT
     SADGGSRGKR ILLGGEKALP FFPDAPMPNR NQVTIDVFDM RLGLAKAVKE NYDDVMDNPG
     EWAKKNVEKF NADMITIHLI STDPLIKDTS PKDAAKTVEE VLQAVDVPIA IGGSGNPQKD
     PLVLAKAAEV AEGERCLLAS ASLNLDYAAI AEAALKYDHD VLSWTQLDMN AQKELNRKLM
     KQCNVPRDRI IMDPTTAALG YGLDYAYTNM ERIRLAALMG DDELTFPMSS GTTNAWGARE
     SWMVSSPLKE DSDWGPREYR GPIWEIITGL SLAIAGNDLF MMMHPTSVAV LKHMTQTLFG
     SIEAEPVDIA NWIGAEV