CFA61_CHLRE
ID CFA61_CHLRE Reviewed; 1147 AA.
AC A8IF44;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Cilia- and flagella-associated protein 61 {ECO:0000305};
DE AltName: Full=Flagellar-associated protein 61 {ECO:0000305};
GN Name=CFAP61 {ECO:0000305}; Synonyms=FAP61 {ECO:0000303|PubMed:17967944};
GN ORFNames=CHLREDRAFT_144011 {ECO:0000312|EMBL:EDP06195.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2]
RP FUNCTION, IDENTIFICATION IN A COMPLEX CONTAINING CFAP61; CFAP91 AND
RP CFAP251, SUBCELLULAR LOCATION, AND INTERACTION WITH CALMODULIN.
RX PubMed=17967944; DOI=10.1083/jcb.200703107;
RA Dymek E.E., Smith E.F.;
RT "A conserved CaM- and radial spoke associated complex mediates regulation
RT of flagellar dynein activity.";
RL J. Cell Biol. 179:515-526(2007).
CC -!- FUNCTION: As component of a spoke-associated complex, regulates
CC flagellar dynein activity by mediating regulatory signals between the
CC radial spokes and dynein arms. {ECO:0000269|PubMed:17967944}.
CC -!- SUBUNIT: Identified in a spoke-associated complex containing CFAP61,
CC CFAP91 and CFAP251; the complex is associated with the radial spokes in
CC the axoneme (PubMed:17967944). The complex associates with Calmodulin;
CC the association is calcium sensitive (PubMed:17967944).
CC {ECO:0000269|PubMed:17967944}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000269|PubMed:17967944}.
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DR EMBL; DS496116; EDP06195.1; -; Genomic_DNA.
DR RefSeq; XP_001703513.1; XM_001703461.1.
DR AlphaFoldDB; A8IF44; -.
DR STRING; 3055.EDP06195; -.
DR PaxDb; A8IF44; -.
DR PRIDE; A8IF44; -.
DR EnsemblPlants; PNW85000; PNW85000; CHLRE_03g167600v5.
DR GeneID; 5728997; -.
DR Gramene; PNW85000; PNW85000; CHLRE_03g167600v5.
DR KEGG; cre:CHLRE_03g167600v5; -.
DR eggNOG; ENOG502QSEC; Eukaryota.
DR HOGENOM; CLU_287062_0_0_1; -.
DR InParanoid; A8IF44; -.
DR OMA; PILQRCE; -.
DR OrthoDB; 38948at2759; -.
DR GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IDA:UniProtKB.
DR GO; GO:0003341; P:cilium movement; IDA:UniProtKB.
DR GO; GO:0044782; P:cilium organization; ISS:UniProtKB.
DR Gene3D; 3.50.50.60; -; 2.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR038884; CFAP61.
DR InterPro; IPR032151; CFAP61_N.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR PANTHER; PTHR21178; PTHR21178; 1.
DR Pfam; PF16092; DUF4821; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum.
FT CHAIN 1..1147
FT /note="Cilia- and flagella-associated protein 61"
FT /id="PRO_0000439534"
FT REGION 282..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1147 AA; 121326 MW; A028282018AE3C46 CRC64;
MSNITARQTL TRDVQSVDAL VRQACKAEAN ATLLLGTGLL NLTAVDDKDT VVGYLSLDDV
SCTRLGSGGP GADTWVQQAA ASRFKLGSTA FVRVCATAHL SEIEASAALL RTAFLHMPSL
QTLLMVAGGE LSFTEPGLAA VFSRVGAHKE SGAVLYEAGR DAVVPPLAIR PARVEDHDDM
LPILQRCEVA FPALAKLPEA SRPHEPFALT RVVAGQDERN RVLVAEAEGR LVGFIVMTSD
VDTGSLAETF DLHAYDNFLP PEVYEQQYEA ARDSVRGQKL AMLRHQRQQE KEAEGEGAGE
AGGQGGNGGV SAGMQTDPEQ GEDGEGAAEG EGEGAGEGAG EGGAAAPGTG ADKADDSEEA
EAQLLAAAEP TDEETRAEML AMFAGQAPPA DPTLFAVTML CMDPAFEAQA IEFLTPAFAA
YTDKLYCVVT LPHDSREPAL MGTMTRVAPN PGSLFPEVLF MFHRHALIPD FAVRLGEPGD
LDAVASLVAG MPNADDIVAS FSGAAAAGSA AVALCQGELV GLVTVNPEVD LELLQANFGL
SNHVDLGYQP REQHGEIDMY TMNPIFVHRH RTLVAATMRL LGKTALYYAL PPGQQPPDML
EVLEQVAPRH RTASDKQLQA EFALYVFTRQ AAFKRRRSVN SQIVVVGASE CGLAVVERLL
LDPELQFNYL TLLAPGGIKV GGMACQFTAG VIARLGLEAR VMLLDAEVIG LDRGSKLLDL
SDGSQIFYNQ LVLAAGLQDQ SRYRFAEADP EVAGLLVTEL ELAADFSMND AMVMNSILVY
GNAMGAYHSL AVLEAKGAGE KTRFVAPPGQ QPPLVGVLHA LAGEAGVALP SPEPRDLAGL
SVVQPVGPEL HASATLIDPA DPGPREELPV DLVVGCEPPS VSRSLFTCLN DASLVFDGRL
VVDGAFRTND PAIYAGGSLA KLSRRYGGTH LEHYNSRDVG SRLASSLVSF FNAGPDEPQP
AATAAAPPPA LHRARAVGCS LPGGNYFVYA GCPAALQRPS TAAPEGGYEM KTASERGLTR
ITLDGEGRVH SLMYLGRVAV NAPRLGSLVG LHANYLNSLA PKYQAGDIKC LLSFITEPWS
ELLYNESFPE LRETLLEVAL AELSAGGREV DGGMVEWVTH AQDAVLEFAR AHAAELPGYT
MPSAART
