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CFA65_CHLRE
ID   CFA65_CHLRE             Reviewed;        2118 AA.
AC   A8JFU2;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Cilia- and flagella-associated protein 65 {ECO:0000305};
DE   Flags: Fragment;
GN   Name=CFAP65 {ECO:0000250|UniProtKB:Q6ZU64};
GN   Synonyms=FAP65 {ECO:0000303|PubMed:15998802};
GN   ORFNames=CHLREDRAFT_153955 {ECO:0000312|EMBL:EDO97267.1};
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC-503;
RX   PubMed=17932292; DOI=10.1126/science.1143609;
RA   Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA   Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA   Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA   Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA   Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA   Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA   Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA   Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA   Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA   Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA   Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA   Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA   Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA   Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA   Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA   Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA   Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA   Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA   Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA   Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA   Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT   "The Chlamydomonas genome reveals the evolution of key animal and plant
RT   functions.";
RL   Science 318:245-250(2007).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=15998802; DOI=10.1083/jcb.200504008;
RA   Pazour G.J., Agrin N., Leszyk J., Witman G.B.;
RT   "Proteomic analysis of a eukaryotic cilium.";
RL   J. Cell Biol. 170:103-113(2005).
CC   -!- FUNCTION: May play a role in flagellar formation and mobility.
CC       {ECO:0000250|UniProtKB:Q3V0B4}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane
CC       {ECO:0000269|PubMed:15998802}; Single-pass membrane protein
CC       {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q3V0B4}.
CC   -!- SIMILARITY: Belongs to the CFAP65 family. {ECO:0000305}.
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DR   EMBL; DS496178; EDO97267.1; -; Genomic_DNA.
DR   RefSeq; XP_001702074.1; XM_001702022.1.
DR   AlphaFoldDB; A8JFU2; -.
DR   STRING; 3055.EDO97267; -.
DR   PaxDb; A8JFU2; -.
DR   PRIDE; A8JFU2; -.
DR   EnsemblPlants; PNW81405; PNW81405; CHLRE_07g354551v5.
DR   GeneID; 5727614; -.
DR   Gramene; PNW81405; PNW81405; CHLRE_07g354551v5.
DR   eggNOG; ENOG502QSJW; Eukaryota.
DR   HOGENOM; CLU_232155_0_0_1; -.
DR   InParanoid; A8JFU2; -.
DR   OrthoDB; 87636at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 10.
DR   InterPro; IPR013783; Ig-like_fold.
PE   1: Evidence at protein level;
KW   Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Coiled coil; Cytoplasm; Flagellum; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..2118
FT                   /note="Cilia- and flagella-associated protein 65"
FT                   /id="PRO_5002722409"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          615..736
FT                   /note="MSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00132"
FT   REGION          1007..1029
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1764..1909
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1924..1958
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          2016..2045
FT                   /evidence="ECO:0000255"
FT   NON_TER         2118
SQ   SEQUENCE   2118 AA;  220136 MW;  EBE3014374EC5C07 CRC64;
     MSSSRGSLRA LLLAAAAAAA AAAGAVSNKL GYWFSCRRFG LDCPEQLEWR HWNPGTEYVK
     QLVLKNVSTS VLKIRFKQPT SKAFGMDFPE PFKLRPGMSQ PLKVVFRPLK QQHYSDNVEL
     FVGNVSCLVP VHAYTPVTHI EVPPALDFGF TPTKETVTAQ LPVRNTGDVR VDVLWKLDAP
     FSISPLFASL APGEVVAFTA SFTPPEACSY TASAACQLES GAAAICKISG IGKFPYLSVE
     QAGVDFGAVV VGQRVERLVR FGNHSVVPAH FAVTHDEAGP DDGVFTVGPA RGTLGPEEYS
     MLKLSYTPRA TGTFSSETFH IGTAGGNRVA LNLRGTAVAP LVTLSTRAFN FGNVAAGATA
     SRVLYIRNHS AVPVPYDFQV DPLDVFAISR TRGVLAPDST AHVTITFRPM AGLAANLWRR
     VTLLLKDAEP QGVDLVATAY TDKSRPPPLS QRHVERYMAR VLSGGPAVEE SQLDSKPPSA
     ATGDPAAALT VDSDALDFGS CSRLSASEYR SVTVTNHTPA KLTAFVLVPE WADPGAAPGD
     APQRVFQVFP ESADMRPYGQ ATFKVAFRPP RDAAFFSQQL ALVAHTKSQR NFRLVAEHQV
     LPAWCVPLRA TGNTFLHSNP EFGPKVELSS RAVAFPPCRP GERVHQTLLI ANSGDTPVAF
     SFGAAGAALG PLFSAKPAAG VVPPQGHVLV ALRFAPTDTR PAAANALVTF NGVASNAVSV
     SLRGAAHTPR LTTDLPSSTL YFRPTCVGAS SQRAVTLHNP SRVPVAFRWR LPARLQGLVT
     VSPAAGALRG NESVQLQWSF TPAAQKLYEA RAACLVMSPP EAANGNAAGA TASAASLFPG
     AGLATGIEWY EGAGATAALA GMGEEEAADA VLLSLVGEGT QGAVALEPPS LELGDLRVGH
     PVRRPLLLQN CSDGVLRYSL EVGPAEDDQP PAGDATLVDF TAGLDSAAEG GVGGGAGGAG
     GAALECWVDE PEGALPARAS KTVMVTLFPR YRKRYSLQVR CRSSTVAPLL TGPNRPPSGG
     AGPRPLDAGS EAAAAAAAAA AAAAAPLPPP VIAPLTASTT FPTLEVTDVY CEGLPKQLLW
     QLLGLNDLNH HLRTEVTATE LRLRAAQDRG ALTTEAASAA MRPFLMEFGT HGLGGRPRVV
     HVEISNPTPL PASWQLHSFD DPDGVELENW VEPGRPRTEG ERMRDLIAEY KLFEMRPRSG
     ELEPGARCTV TIEFRPSVEG SFELPVFLHI TDGKRLRLQL QAVTTPEPLQ LLALPPPLRT
     FRLEPVALGE RAPPLQMYVL RNGGPAPLHW RLDTAPLAAL AEASWGHPVL ELVGPEEGDI
     EEGGVAAINW RFSPLEAKEY RVEVPVLLGD GGIEVIELLG RGFAPPPAPP HGAAAVQLIG
     PGAATSPAAP TTAAEDDDTP AAALDSVGGD AEAEAARAAA AADRDWITWR GLSSAPSAGM
     AGRLALVDHD LVSLGVTPVR GLTRRIIVLT NKSRYPLAFD WDLGCLAPPP PPGLAATQRA
     AAASAMMGLG GGSLLPASQL QLLAGRPLQG ALAISPAAGS LEPGERLVCR VSLHAGVTPQ
     VFEGEVRCHV RIDDDAVAEA EAAAAAAAAA GAAAVAAELP FVEQVEEVIA EAPVRGPPAP
     PPAVAAAQRA SRLRSRLPVH QYMTTAVRTR IEPLNAAFTA TMEARTRRLA DATRPPSWPE
     PQSISVTLRG RILDERQLGA LRYVPPHERA AARAAVVAGA AWVPPAMVPF WEEEGRSTPA
     VSAQPSSQGG GGYGVGGYGG GYGSGGSQGG EASVAPSGGD PGGYSPRGGM ADSWPSLEPG
     LGMEETVVGP PTVGLDLSLS LQHAGGAGGA PGGDGDSDSR PGTPSMTAAA HHHHHHPRHA
     GPAPGSGTAE VMEVTFSGDQ QPTGGPMPSP PSISGAPDPD SATPDDDFAT SDAAVNAAAA
     VRAAGGGMGS PQPVDPGGSA AAAASELAPP ALPPAPPRGG DIEYDALVSA REVLAGLFAE
     LMEDADVVRA VAFLPEHEVP SFAEVRATPP PCYDPAVRAA AEAARAEAEA RAAAEAATKA
     AAEAEAGAAF AIPAAAAQAA TEPPALEDEL AADTELARVL VAPEWRAFAD FVLESAVLGL
     MQESAAGDWE MPEEEVGR
 
 
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