ID   CFA69_CALJA             Reviewed;         941 AA.
AC   B0VXE6;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Cilia- and flagella-associated protein 69 {ECO:0000250|UniProtKB:A5D8W1};
GN   Name=CFAP69 {ECO:0000250|UniProtKB:A5D8W1};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C.,
RA   Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M.,
RA   Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N.,
RA   Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B.,
RA   Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R.,
RA   Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C.,
RA   Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C.,
RA   Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K.,
RA   Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J.,
RA   Tsipouri V., Young A., Green E.D.;
RT   "NISC comparative sequencing initiative.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cilium- and flagellum-associated protein (By similarity). In
CC       the olfactory epithelium, regulates the speed of activation and
CC       termination of the odor response and thus contributes to the robustness
CC       of olfactory transduction pathways (By similarity). Required for sperm
CC       flagellum assembly and stability (By similarity).
CC       {ECO:0000250|UniProtKB:A5D8W1, ECO:0000250|UniProtKB:Q8BH53}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q8BH53}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:A5D8W1}. Note=Localizes to the midpiece of the
CC       sperm flagellum. {ECO:0000250|UniProtKB:A5D8W1}.
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DR   EMBL; DP000590; ABZ80267.1; -; Genomic_DNA.
DR   RefSeq; XP_002751692.2; XM_002751646.3.
DR   AlphaFoldDB; B0VXE6; -.
DR   STRING; 9483.ENSCJAP00000026215; -.
DR   Ensembl; ENSCJAT00000027703; ENSCJAP00000026215; ENSCJAG00000014219.
DR   GeneID; 100405268; -.
DR   KEGG; cjc:100405268; -.
DR   CTD; 79846; -.
DR   eggNOG; ENOG502QV2V; Eukaryota.
DR   GeneTree; ENSGT00390000014274; -.
DR   HOGENOM; CLU_322533_0_0_1; -.
DR   InParanoid; B0VXE6; -.
DR   OMA; MVQCYQN; -.
DR   OrthoDB; 640213at2759; -.
DR   TreeFam; TF328355; -.
DR   Proteomes; UP000008225; Chromosome 8.
DR   Bgee; ENSCJAG00000014219; Expressed in kidney and 6 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0097730; C:non-motile cilium; ISS:UniProtKB.
DR   GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0042048; P:olfactory behavior; ISS:UniProtKB.
DR   GO; GO:1905516; P:positive regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:1990834; P:response to odorant; ISS:UniProtKB.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Differentiation; Flagellum; Olfaction;
KW   Reference proteome; Sensory transduction; Spermatogenesis.
FT   CHAIN           1..941
FT                   /note="Cilia- and flagella-associated protein 69"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000366026"
SQ   SEQUENCE   941 AA;  105754 MW;  9C59B5DA74151B51 CRC64;
     MWTEKAAAMA EAQESGCRNK SSISRQTPVA GAVTEDDEAQ GVFKPMDLNH VIKLLEETNK
     DGLEEKQLKF VKKLVQCYQN GLPLRDLAQI FKILNLCAGK IKNQPRFIES AYDIIKLCGL
     PFLKKKVSDE ITYAEDTANS IALLGDLMKI PSSELRIQIC KCIVDFYHAE PPKKHIPGYQ
     QACSSYKIQM AEVGGLAKTM VQAVTLLENQ LVEKLWVLKV LQHLSTSEVN CSIMMKAQAA
     SGICAHLNDP DPSGQLLFRS SEILWNLLEK SSKEEILPQL SNLECLLALK EVFKNLFMRG
     FSHYDRQLRN DILVITTIIA QNPEAPMIEC GFAKDLILFA TFNEVKSQNI LVKGLKLSNS
     YEDFELKKLL FNIIVILCKD LPTIQLLIEG SVVLALFTYV KKPEKQRTID WSAAQYEELQ
     LHAIATLSSV APLLIEEYMS CQGNAQVLAF LEWCEIEDSF FSHGNSFHGT GGRGNKFAQM
     RYSLRLLRAM VYLEDETVNT DLCEKGTIQQ MIGIFKNIIS KTNEKEEAIV LEIQSDILLI
     LSGLCEHHIQ RKEIFGTEGV DIVLHVMKTD PRKLQSGLGY NVLLFSTLDS IWCCILGCYP
     SEDYFLEKEG IFLLLDVLAL NEKKFCNLIL GIMVEFCDNP KTAAHVNAWR GKKDQTAASL
     LIKLWRKEEK ELGVKRDKNG KIIDTKKPLF TSFQEEQKII PLPANCPSIA VMDVSENIRA
     KIYAILGKLD FENLPGLSAE DFVTLCIIHR YLDFKIGEIW NEIYEEIKLE KLRPVTTDKK
     ALEAITTASE NIGKMVASLQ SEIIESQACQ DVQNEQKVYA KIQATHKQRE LANKSWGNFL
     ARTSNAKTLK KAKRLQEKAI KASRYHERPQ HAIFHPTDIK GLNTTVPSGG VVTVESTPAR
     LVGGPLADTD IALKKLPIRG GALQRVKAVK IEEAPKKSIP T