ID   CFA69_PAPAN             Reviewed;         941 AA.
AC   B0CM26;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Cilia- and flagella-associated protein 69 {ECO:0000250|UniProtKB:A5D8W1};
GN   Name=CFAP69 {ECO:0000250|UniProtKB:A5D8W1};
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C.,
RA   Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M.,
RA   Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N.,
RA   Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B.,
RA   Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R.,
RA   Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C.,
RA   Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C.,
RA   Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K.,
RA   Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J.,
RA   Tsipouri V., Young A., Green E.D.;
RT   "NISC comparative sequencing initiative.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cilium- and flagellum-associated protein (By similarity). In
CC       the olfactory epithelium, regulates the speed of activation and
CC       termination of the odor response and thus contributes to the robustness
CC       of olfactory transduction pathways (By similarity). Required for sperm
CC       flagellum assembly and stability (By similarity).
CC       {ECO:0000250|UniProtKB:A5D8W1, ECO:0000250|UniProtKB:Q8BH53}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q8BH53}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:A5D8W1}. Note=Localizes to the midpiece of the
CC       sperm flagellum. {ECO:0000250|UniProtKB:A5D8W1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DP000509; ABY63618.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0CM26; -.
DR   STRING; 9555.ENSPANP00000018631; -.
DR   eggNOG; ENOG502QV2V; Eukaryota.
DR   Proteomes; UP000028761; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0097730; C:non-motile cilium; ISS:UniProtKB.
DR   GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0042048; P:olfactory behavior; ISS:UniProtKB.
DR   GO; GO:1905516; P:positive regulation of fertilization; ISS:UniProtKB.
DR   GO; GO:1902093; P:positive regulation of flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:1990834; P:response to odorant; ISS:UniProtKB.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   SUPFAM; SSF48371; SSF48371; 2.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Differentiation; Flagellum; Olfaction;
KW   Reference proteome; Sensory transduction; Spermatogenesis.
FT   CHAIN           1..941
FT                   /note="Cilia- and flagella-associated protein 69"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000366027"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   941 AA;  105783 MW;  38ECEB9C3EC75126 CRC64;
     MWTEEAAATA EARESGIRNK SSSSSQIPVV GVVTEDNEAQ GVFKPMDLNR VIKLLEETDK
     DGLEEKQLKF VKKLVQCFQN GLPLRDLAQI FKILNLCAGK IKNQPRFVES AYDIIKLCSL
     PFLKKKVSDE ITYAEDTANS IALLGDLMKI PSSELRIQIC KCIVDFYHAE PPKKHIPGYQ
     QASSSYKIQM AEVGGLAKTM VQSITLLEHQ LVEKLWVLKV LQHLSTSEVN CTIMMKAQAA
     SGICTHLNDP DPSGQLLFRS SEILWNLLEK SSKEEVIQQL SNLECLLALK EVFTNLFMRG
     FSHYDRQLRN DILVITTIIA QNPEAPMIEC GFTKDLILFA TFNEVKSQNL LVKGLKLSNS
     YEDFELKKLL FNVIVILCKD LPTVQLLIDG KVILALFTYV KKPEKQKIMG WSAAQHEELQ
     LHAIATLSSV APLLIEEYMS CQGNARVLAF LEWCESEDPF FSHGNSFHGT GGRGNKFAQM
     RYSLRLLRAM VYLEDETVNT DLCEKGTIQQ MIGIFKNIIS KPNEKEEAIV LEIQSDILLI
     LSGLCENHIQ RKEIFGTEGV DIVLHVMKTD PRKLQSGLGY NLLLFSTLDS IWCCILGCYP
     SEDYFLEREG IFLLLDVLAL NQKKFCNLIL GIMVEFCDNP KTAAHVNAWQ GKKDQTAASL
     LIKLWRKEEK ELGVKRDKNG KIIDTKKPLF TSFQEEHKII PLPANCPSIA VMDVSENIRA
     KIYAILGKLD FENLPGLSAE DFVTLCVIHR YLDFKIGEIW NEIYEEIKLE KLRPVTIDKK
     ALEAITTASE NVGKMVASLQ SEIIESQARQ DVQNEQKVYA KIQATHKQRE LANKSWENFL
     ARTSNAKTLK KAKRLQEKAI EASRYHKRPQ NAVFHGTDIK GLNTTVPSGG VVTVESTPAR
     LVGGPLADTD IALKKLPIRG GALQRVKAVE IVDAPKKSIP T