CFA70_MACFA
ID CFA70_MACFA Reviewed; 1009 AA.
AC Q95LN2; Q4R6A6; Q95JP4; Q95LZ0;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Cilia- and flagella-associated protein 70 {ECO:0000305};
GN Name=CFAP70 {ECO:0000305};
GN ORFNames=QtsA-14176 {ECO:0000312|EMBL:BAB64444.1},
GN QtsA-14782 {ECO:0000312|EMBL:BAB63082.1},
GN QtsA-18431 {ECO:0000312|EMBL:BAB69725.1},
GN QtsA-18615 {ECO:0000312|EMBL:BAE01369.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Testis;
RA Hashimoto K., Osada N., Hida M., Kusuda J., Tanuma R., Hirai M., Terao K.,
RA Sugano S.;
RT "Isolation of novel full-length cDNA clones from macaque testis cDNA
RT libraries.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Axoneme-binding protein that plays a role in the regulation
CC of ciliary motility and cilium length. {ECO:0000250|UniProtKB:D3YVL2}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:Q5T0N1}. Cytoplasm, cytoskeleton, flagellum
CC basal body {ECO:0000250|UniProtKB:Q5T0N1}. Cell projection, cilium
CC {ECO:0000250|UniProtKB:D3YVL2}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:D3YVL2}. Note=Present all along the flagellum,
CC with a marked signal at the base of the flagellum.
CC {ECO:0000250|UniProtKB:Q5T0N1}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q95LN2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q95LN2-2; Sequence=VSP_026295;
CC Name=3;
CC IsoId=Q95LN2-3; Sequence=VSP_026292, VSP_026296;
CC Name=4;
CC IsoId=Q95LN2-4; Sequence=VSP_026293, VSP_026294;
CC -!- DOMAIN: The conserved TPR domains are dispensable for ciliary
CC targeting. The N-terminal half is important for cilary localization
CC and/or binding to the axoneme. {ECO:0000250|UniProtKB:D3YVL2}.
CC -!- SIMILARITY: Belongs to the CFAP70 family. {ECO:0000305}.
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DR EMBL; AB072756; BAB69725.1; -; mRNA.
DR EMBL; AB070137; BAB63082.1; -; mRNA.
DR EMBL; AB071051; BAB64444.1; -; mRNA.
DR EMBL; AB169281; BAE01369.1; -; mRNA.
DR AlphaFoldDB; Q95LN2; -.
DR SMR; Q95LN2; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR GO; GO:0036157; C:outer dynein arm; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium; Cytoplasm; Cytoskeleton;
KW Flagellum; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1009
FT /note="Cilia- and flagella-associated protein 70"
FT /id="PRO_0000291914"
FT REPEAT 498..531
FT /note="TPR 1"
FT REPEAT 635..668
FT /note="TPR 2"
FT REPEAT 669..702
FT /note="TPR 3"
FT REPEAT 704..736
FT /note="TPR 4"
FT REPEAT 888..921
FT /note="TPR 5"
FT REPEAT 923..954
FT /note="TPR 6"
FT REPEAT 956..988
FT /note="TPR 7"
FT REGION 410..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 216..863
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_026292"
FT VAR_SEQ 311..320
FT /note="ITRVPLVTVP -> LFMFTLTWTV (in isoform 4)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_026293"
FT VAR_SEQ 321..1009
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_026294"
FT VAR_SEQ 551..974
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_026295"
FT VAR_SEQ 864..871
FT /note="KEIPTKKE -> NGNHSEAK (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_026296"
FT CONFLICT 14
FT /note="T -> A (in Ref. 2; BAB63082)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="P -> L (in Ref. 1; BAB69725)"
FT /evidence="ECO:0000305"
FT CONFLICT 384
FT /note="D -> E (in Ref. 2; BAB64444)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1009 AA; 113137 MW; 8CD75B931D240308 CRC64;
MEQVPSTGRL VQITVTEGYD LKGFKGDTPV TFIRAEFNQV VLGDSAKITV SPEGSAKYNF
TSSFEFNPEG GITLDDLAHK PVFLTVTEVL PKEKKQKEEK TLILGQAVVD LLPLLEGQSS
FQTTVPLHPV QGSPLETPRS SAKQCSLEVK VLVAEPLLTT AQISGGNLLK VTLEAAYSVP
ESFIPTGPGQ NYMVGLQVPS LGEKDYPILF KNGTLKLGGE REPVPRPKKW PIANILAPGA
NNIPDAFIVG GPYEEEEGEL NHPEDSEFRN QAECIKKRII WDLESRCYLD PSAVVSFQKR
IADCRLWPVE ITRVPLVTVP KGKAGKTEKT DEEGQLSFHG VAYVNMVPLL YPGVKRIRGA
FHVYPYLDSV VHEKTKCLLS LFRDIGHHLI HNNKIGGINS LLSKQAVSKN LKEDKPVKEK
DIDGRPRPGD VQAPSIKSQS SDTPLEGEPP LSHNPEGQQY VEAGTYIVLE IQLDKALVPK
RMPEELARRV KEMIPPRPPL TRRTGGAQKA VSDYHTQIKN ISRAILDEYY RMFGKQVAKL
ESDMDSETLE EQKCQLSYEL NCSGKYFAFK EQLKHAVVKI VREKYLKTTS FESQEELQTF
ISELYVFLVD QMHVALNQTM PDDVQGTIAT IFTSSEQLRL FAFEAEVNEN FEMAAAYYKE
RLVREPQNLD HWLDYGVFCL LTEDNIKAQE CFRKALSLNQ SHIHSLLLCG VLAVLLENYE
QAEIFFEDAT CLEPTNVVAW TLLGLYYEIQ NNDIRMEMAF HEASKQLQAQ MLQAQVTKQK
SAGVVEDVEE RGKRESSLGP WGITNGSATA IKVEAPAGPG AALSILDKFL EESSKLQSDS
QEPILTTQTW DPSINQKPSN TFIKEIPTKK EACYERTISF VVDASEMHFI FLRLGLIYLE
EKEYEKAKKT YMQACKRSPS CLTWLGLGIA CYRLEELTEA EDALSEANAL NNYNAEVWAY
LALVCLKVGR QLEAEQAYKY MIKLKLKDEA LLAEIHTLQE TVGFGNPSF
